and VLDL
FoxO1 mediates insulin dependent regulation of hepatic VLDL production in mice
... augmented VLDL production, and elevated plasma triglyceride ...and VLDL production in adult ...for VLDL overproduction and hypertriglyceridemia in ...
19
Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
... How ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) lower plasma lipid levels is incompletely understood. We previously showed that marine ω-3 PUFAs (docosahexaenoic acid [DHA] and eicosapentaenoic acid) stimulate a ...
12
Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia
... Measurement of VLDL production. Mice were fasted for 6 hours at the beginning of the light cycle. The mice were anesthetized with sodium pentobarbital (80 mg/kg) and then injected in the external jugular vein with ...
11
Phospholipids in lipoproteins: compositional differences across VLDL, LDL, and HDL in pregnant women
... We aimed to characterize the phospholipid compos- ition of LDL, HDL and VLDL in obese and lean preg- nant women, which, apart from lipoprotein species in pregnancy in general [18], so far has not been described in ...
11
Very-Low-Density Lipoprotein (VLDL)-Producing and Hepatitis C Virus-Replicating HepG2 Cells Secrete No More Lipoviroparticles than VLDL-Deficient Huh7.5 Cells
... and VLDL is concerned as VLDL are clearly both apoB and apoE ...precisely, VLDL synthesis seem to have important roles regarding HCV particle assembly, secretion, and ...in VLDL-deficient ...
16
Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice
... and VLDL and LDL were separated by ultra- ...in VLDL and LDL in mice injected with either control empty adenovirus or ...in VLDL and LDL in Ldlr –/– mice injected with empty adenovirus or different ...
14
Modulation of VLDL triglyceride metabolism
... accelerated VLDL-TG clearance from plasma to a similar ...enhance VLDL- TG ...accelerates VLDL-TG clearance through a different, as yet unidentified ...
174
Apo E structure determines VLDL clearance and atherosclerosis risk in mice
... tein fractions were dialyzed against PBS. Plasma (100 µL) pooled samples were fractionated by fast protein liquid chro- matography (FPLC) using a Superose 6 HR10/30 column (Pharmacia Biotech Inc., Piscataway, New Jersey, ...
9
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction
... Impaired cardiac function is associated with myocardial triglyceride accumulation, but it is not clear how the lipids accumulate or whether this accumulation is detrimental. Here we show that hypoxia/ischemia-induced ...
17
Nuclear envelope–localized torsinA LAP1 complex regulates hepatic VLDL secretion and steatosis
... for VLDL assembly and ...impaired VLDL secretion and greater degree of steatosis, as well as the altered size distribution and abnormal localization of lipid droplets in the A-CKO mice and requires further ...
17
The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor
... the VLDL receptor is not completely understood. The observation that VLDL re- ceptor mRNA is highly expressed in skeletal muscle, heart, and adipose tissue, but not liver (59, 60), has led to the hypoth- ...
13
Effects of a low fat, high carbohydrate diet on VLDL triglyceride assembly, production, and clearance
... of VLDL-TG concurrent with elevations in fasting chylomicron remnant concen- trations in the HTG ...plasma VLDL-TG was higher in HTG subjects compared with NL subjects on the higher-fat diet, but was not ...
11
Effect of Phoenix deactylifera on high fat diet induced obesity
... of VLDL in plasma of HFD treated rats when compared with the control treatment with phoenix dactylifera extract reduced VLDL level significantly VLDL in highly rich in triglycerides and is involved ...
5
Hypolipidemic Effect of Hyphaene thebaica (Doum palm) in Induced Hypercholestrolemic Wistar Albino Rats
... comparative study on hypocholestrolemic effect of different fractions of H. thepaica (Doum) in experimental animals to investigate their effects on serum cholesterol, triglycerides and lipoproteins (HDL, cholesterol and ...
5
Inhibition of hormone stimulated lipolysis by clofibrate A possible mechanism for its hypolipidemic action
... Since plasma FFA are the principal lipid precursors in hepatic VLDL-triglyceride fatty acid production 10, 60 and because plasma FFA concentration determines hepatic FFA uptake and VLDL [r] ...
12
Evaluation of pathways for the cellular uptake of high density lipoprotein cholesterol esters in rabbits
... reutilization. Several pathways may be involved in that process. Tracer kinetics were used to estimate the contributions of the various pathways to cellular uptake of HDL CE in rabbits. Tracers of HDL CE, HDL apo A-I, ...
17
Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans
... mmol/liter), VLDL triglyceride production decreased by ...and VLDL apo B production decreased by ...mmol/liter), VLDL triglyceride production decreased to a lesser extent than with insulin alone (P = ...
10
ChREBP Rather than SHP Regulates Hepatic VLDL Secretion
... affect SHP target gene (Cyp7a1) mRNA levels, this suggested that ChREBP does not modulate SHP 257. transactivity[r] ...
11
Modulation of very low density lipoprotein production and clearance contributes to age and gender dependent hyperlipoproteinemia in apolipoprotein E3 Leiden transgenic mice
... hepatic VLDL triglyceride production and VLDL-apo B secretion are in line with the ob- served differences in lipid levels between untreated male and female APOE*3-Leiden ...on VLDL clearance rate, ...
10
Characterization of very low density lipoprotein particle diameter dynamics in relation to egg production in a passerine bird
... the VLDL particle diameter distributions of laying and non- laying females, t-tests were ...and VLDL particle diameter distribution range of zebra finches, and modal and median VLDL particle diameter ...
11