androgen deprivation therapy
Androgen deprivation therapy for prostate cancer: long-term safety and patient outcomes
... Androgen deprivation therapy (ADT) is one of the most common forms of treatment for advanced prostate cancer (PCa). The benefits of ADT as the primary treatment or in combination with other therapies ...
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Long-term results of radical prostatectomy with immediate adjuvant androgen deprivation therapy for pT3N0 prostate cancer
... adjuvant androgen deprivation therapy consisted of an- drogen suppression with orchiectomy (n = 17), LHRH analog (n = 64), combined androgen blockade with orchiec- tomy or LHRH analog and ...
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Combining Enzalutamide with Abiraterone, Prednisone, and Androgen Deprivation Therapy in the STAMPEDE Trial
... STAMPEDE (ClinicalTrials.gov identifier NCT00268476) is a flagship multiarm, multistage, open-label, randomised controlled trial in the United Kingdom and Switzerland evaluating the combination of novel treatment ...
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Quality of life effects of androgen deprivation therapy in a prostate cancer cohort in New Zealand: can we minimize effects using a stratification based on the aldo-keto reductase family 1, member C3 rs12529 gene polymorphism?
... Androgen deprivation therapy (ADT) is an effective treatment in men with advanced metastatic PC and those with high risk tumors in combination with radiation therapy (RT) ...testicular ...
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Duration of androgen deprivation therapy with maximum androgen blockade for localized prostate cancer
... The advantages of primary androgen deprivation therapy (ADT) for localized prostate cancer continue to be con- troversial. A population-based epidemiological study indicated that primary ADT does not ...
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Androgen deprivation therapy as backbone therapy in the management of prostate cancer
... Plus Androgen Deprivation Therapy (ADT) versus ADT Alone in Newly Diagnosed Participants With High-Risk, Metastatic Hormone-Naive Prostate Cancer (LATITUDE), Study of JNJ-56021927 (ARN-509) Plus ...
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Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy
... Androgen deprivation therapy induces apoptosis or cell cycle arrest in prostate cancer (PCa) ...in androgen-deprived PCa ...in androgen-sensitive PCa cells, while castration-resistant ...
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Bone mineral density in Jamaican men on androgen deprivation therapy for prostate cancer
... of androgen depri- vation therapy was determined as well as the duration of ...of androgen deprivation therapy included steroidal and non-steroidal anti-androgens, LHRH analo- gues, ...
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Cardiac Structure and Function in Men with Prostate Cancer Receiving Androgen Deprivation Therapy and the Effects of Recreational Small Sided Football Training: A Randomized Controlled Trial
... Purpose: Androgen deprivation therapy (ADT) is a cornerstone in prostate cancer (PCa) management that prolongs PCa-free and overall survival, but effects of ADT on human cardiac function have not ...
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Androgen deprivation therapy for androgen receptor-positive advanced salivary duct carcinoma: A nationwide case series of 35 patients in The Netherlands.
... the androgen receptor (AR)(4); the percentage of AR positivity varies between 67 and ...with androgen deprivation therapy (ADT), such as bicalutamide, an androgen receptor antagonist ...
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“Androgen Deprivation Therapy for Prostate Cancer an Update on Triptorelin” by Ali Hamdan Fahad, Iraq.
... disease. Androgen deprivation therapy (ADT) is the mainstay palliative treatment for men with locally advanced and metastatic prostate cancer, and aims to reduce testosterone to levels obtained by ...
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RiseTx: testing the feasibility of a web application for reducing sedentary behavior among prostate cancer survivors receiving androgen deprivation therapy
... Physical activity (PA) has a positive impact on clinical out- comes such as improvement in overall quality of life (QoL), cancer-specific mortality, and reducing treatment-related toxicities in cancer survivors [4], ...
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Cardiovascular health in men on androgen deprivation therapy for prostate cancer
... Moreover, cardiovascular disease is now considered a leading cause of death for patients with cancers of the breast, prostate, colon-rectum and endometrium Baade et al., 2006; Patnaik et[r] ...
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Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer
... over the last several decades has contributed to a greater understanding of the detailed molecular mechanisms driving carcinogenesis in specific organ systems [179, 180]. While an attractive concept for scientists, ...
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Adaptive phenotype drives resistance to androgen deprivation therapy in prostate cancer
... PCa cells with low or null PSA expression have an im- portant role in the progression to CRPC: their increase correlated with patients ’ shorter survival [10] and ADT led to their expansion [11, 12]. Accordingly, among ...
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Original Article Androgen deprivation therapy induces androgen receptor-dependent upregulation of Egr1 in prostate cancers
... the androgen-independent growth of prostate carcinoma cells both in vitro and in ...after androgen deprivation in pros- tate cancer and whether the elevated Egr1 expression contributes to the ...
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Androgen deprivation therapy prevents bladder cancer recurrence
... ADT prevents BC recurrence even if cases are separately analyzed in each grade. In addition, among all of these clinicopathologic factors, only patient age was an independent prognosticator for BC recurrence in our ...
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Biopsychosocial impact of prostate cancer and androgen deprivation therapy
... Methods: Patients were prospectively recruited and consented at a single academic health sciences centre in Ontario, Canada. Inclusion criteria included those men with adenocarcinoma of the prostate and either on ...
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Prognosis of prostate cancer with initial prostate-specific antigen >1,000 ng/mL at diagnosis
... Results: The mean PSA at PCa diagnosis in this cohort was 3,323 ng/mL (1,003–23,126, median: 2,050 ng/mL). Most patients were in the age group 65–79 years (55/90, 61%). Males older than 80 years had a poor prognosis ...
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Treatment of Oligometastatic Hormone Sensitive Prostate Cancer: A Comprehensive Review
... metastasis-directed therapy using surgery and radiation therapy (RT), can improve survival outcomes with minimal risk of adverse ...of androgen-deprivation ...
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