Androgen independent
PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells
... In the present study, we uncover a novel mechanism for PRK1-controlled migration of androgen-independent PCa. We show that PRK1 controls migration and invasion but not proliferation of PC-3M-luc2 cells. ...
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Evaluation of androgen-induced effects on the uptake of [18F]FDG, [11C]choline and [11C]acetate in an androgen-sensitive and androgen-independent prostate cancer xenograft model
... examined androgen-induced effects on metabolic PET imaging of the androgen-independent yet androgen-responsive PCa xenograft model ...an androgen-induced increased uptake of [ 18 F]FDG ...
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Myc confers androgen independent prostate cancer cell growth
... We have also demonstrated that c-myc expression could immortalize human primary prostate epithelial cells by inhibiting the p16-RB pathway and inducing hTERT expression (Gil et al., unpublished observa- tions). The fact ...
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Original Article Expression profiling of genes in androgen metabolism in androgen-independent prostate cancer cells under an androgen-deprived environment: mechanisms of castration resistance
... become androgen independent and grow quickly over a period of 18 to 20 months with an ensuing median survival of 1 to 2 ...from androgen dependence to indepen- dence in prostate tumors are ...
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SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth
... in androgen-independent PC-3 prostate cancer cells compared with androgen-dependent LNCaP prostate cancer ...of androgen-independent prostate ...
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Carmustine enhances the anticancer activity of selenite in androgen-independent prostate cancer cells
... of androgen-independent (hormone-refractory) prostate ...carmustine-sensitized androgen-independent human prostate can- cer cells. Androgen-dependent LNCaP cells exhibited a significant ...
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Inverse baseline expression pattern of the NEP/neuropeptides and NFκB/proteasome pathways in androgen-dependent and androgen-independent prostate cancer cells
... AD: androgen-dependent; AI: androgen-independent; AMC: 7-Amino-4- methylcoumarin; BCA: bicinchoninic acid; BSA: bovine serum albumin; ECACC: European collection of cell cultures; ECE-1: endothelin ...
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Original Article Differential expression of long non-coding RNAs in prostatic carcinoma cell line LNCaP after occurrence of androgen independent transformation
... Microarray profiling of 30,586 lncRNAs (Figure 1A) and 26,109 coding transcripts (Figure 1B) was carried out using Arraystar Human LncRNA Microarray v3.0 (Kangcheng, Shanghai, China). The lncRNAs and coding transcripts ...
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Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling
... treating androgen-inde- pendent LNCaP C4-2B cells with inhibitor combinations, with values below ...of androgen dependent LNCaP-C33 cells, the sponta- neously arising androgen-independent ...
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<p>The Effects of Matrine in Combination with Docetaxel on Castration-Resistant (Androgen-Independent) Prostate Cancer</p>
... Currently, in China, a lot of hospitals, including hospitals of integral medicine of traditional Chinese and western medicine, use combined methods of the traditional Chinese medicine and western medicine to treat a ...
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P2 purinergic receptor agonists inhibit the growth of androgen independent prostate carcinoma cells
... human androgen- independent prostate carcinoma cells express functional P2-purinergic receptors linked to phospholipase C, and that agonists of this receptor are markedly growth ...
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A Single Therapeutic miRNA Rescues the Oncolysis of Androgen Activated Prostate Specific Virus in Androgen Independent Cell Model
... assay independent of adenovirus (Figure 1(c)) and in the crystal violet assay when expressed from a replica- tion deficient adenovirus in DU145 cells (Figure ...negative androgen resistant DU145 ...have ...
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Constitutively active follicle stimulating hormone receptor enables androgen independent spermatogenesis
... sate for missing or insufficient T action, e.g., in oligozoospermia due to partial androgen resistance. Indeed, a study using 3- to 6-fold higher than the standard dose of FSH (75 IU, 2 to 3 times weekly) showed ...
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Docetaxel-titanate nanotubes enhance radiosensitivity in an androgen-independent prostate cancer model
... Notes: Pc-3 cells were treated with free DTX, activated DTX (DTX-PMPI), DTX grafted to TiONts (TiONts-DTX) or bare TiONts (concentration equivalent to TiONts- DTX) for 96 h. Each point corresponds to the mean values of ...
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High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone
... depletion), Boyden chamber migration, and long-term culture. During prostate cancer growth and metastasis, changes have been observed in the expression patterns of several genes. One such change is a decreased expression ...
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Chemopreventive potential of curcumin in prostate cancer
... corresponding androgen receptors (AR), are essential for the morpho- genesis and development of the prostate but are also involved into the malignant transformation of this gland ...by androgen depletion ...
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Original Article Estrogen receptor β inhibits prostate cancer cell proliferation through downregulating TGF-β1/IGF-1 signaling
... [3]. Androgen-deprivation therapies of surgical and medical castration are initially effective in the management of prostate can- cer, but the majority of tumors will evolve into androgen-independent ...
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Oridonin Up-regulates Expression of P21 and Induces Autophagy and Apoptosis in Human Prostate Cancer Cells
... In the present study, we detected the ORI-induced autophagy and the role of autophagy in cell death in PC-3 (androgen-independent) and LNCaP (androgen-dependent) prostate[r] ...
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ANTIPROLIFERATIVE ACTIVITY OF EXTRACTS OF GNAPHALIUM GRACILE H.B.K. AGAINST CANCER CELL LINES
... carcinoma androgen-dependent LNCaP cells (figure ...28, androgen-independent prostate cancer PC-3, and androgen-dependent LNCaP cells (figure ...
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Effects of Antiproliferative Protein (APP) on Modulation of Cytosolic Protein Phosphorylation of Prostatic Carcinoma Cell Line LNCaP
... two androgen-independent prostatic carcinoma cell lines, PC3 and Du-145 was shown to inhibit selectively cell proliferation of androgen-dependent prostate cancer cell line LNCaP in a dose dependent ...
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