Androgen receptor, AR
Androgen receptor splice variants circumvent AR blockade by microtubule-targeting agents
... the androgen receptor (AR) has been established as a hallmark of ...of AR (AR-Vs) that lack the ligand-binding domain (LBD) have been ...variant, AR-V7, was ...relevant ...
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Integrating phosphoproteomics into the clinical management of prostate cancer
... Unlike in early stage disease, where the development of the PSA test to screen patients for prostate cancer has both raised awareness and improved survival [1], find- ing useful biomarkers for patient stratification or ...
6
Related individuals with different androgen receptor gene deletions
... Abstract We have identified different members of one family affected by androgen insensitivity syndrome who have deletions of different exons of the X-linked androgen receptor AR gene.. [r] ...
7
Androgen receptor as potential therapeutic target in metastatic endometrial cancer
... [2]. Androgen receptor (AR) is a hormone receptor less studied in endometrial cancer, although a target for treatment in other cancers [9, ...aberrant androgen signaling is central to ...
10
Recent advances on the progressive mechanism and therapy in castration-resistant prostate cancer
... tumoral androgen is related to the tumor microenvironment to a certain ...through androgen receptor (AR) activation in CRPC cells, could also be enhanced by prostate stromal ...
12
Regulation of Androgen Receptor Expression Alters AMPK Phosphorylation in the Endometrium: In Vivo and In Vitro Studies in Women with Polycystic Ovary Syndrome
... [10], androgen is also essential for female reproduction through the activation of androgen receptor (AR), which belongs to a member of the steroid receptor superfamily and regulates ...
14
ARA55 in Cancers: A Double-Edged Sword
... glucocorticoid receptor coactivation and interacting with multiple proteins such as Androgen Receptor (AR), Cysteine-Rich Protein 2 (CRIP2) and Smad Family Member 3 ...
5
Kinase mediated regulation of common transcription factors accounts for the bone protective effects of sex steroids
... the androgen receptor (AR) ...the receptor causes homo- or heterodimerization of the protein and changes its conformation in such a way that it allows the dimer to interact with several ...
15
Analysis of androgen receptor and anti-Müllerian hormone pathways in human granulosa cells under luteinizing hormone treatment
... cells. Androgen action is mediated by the androgen receptor (AR), which, like other members of the steroid receptor superfamily, interacts directly with target genes to regulate ...
11
LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models
... S4. Androgen response element (ARE) luciferase reporter assay, in response to androgen receptor (AR) antagonists, for the AR wild type (WT) or V7 splice variant ...either AR WT ...
9
Effects of Estradiol and Testosterone on the Expression of Estrogen Receptor and Androgen Receptor Genes in Female and Male Nile Tilapia, Oreochromis niloticus
... estrogen receptor (ER) and androgen receptor (AR) in the liver, gonads, kidney, and intestine of female and male Nile Tilapia, Oreochromis ...and AR- α 1 were ...(P<0.05). AR- ...
7
Persistent androgen receptor addiction in castration-resistant prostate cancer
... the androgen receptor (AR) signaling pathway often underlies the development of castration-resistant prostate cancer ...the AR and ultimately to the development of the potent next-generation ...
14
Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer
... is androgen receptor (AR)- and ...on AR, which indicates the importance of AR activity also for ...the AR activity in CRPC, which indicates an adaptation of the AR ...
14
Expression of hypothalamic-pituitary-gonadal axis-related hormone receptors in low-grade serous ovarian cancer (LGSC)
... gen receptor (ER) and progesterone receptor (PR) ex- pression levels in LGSC [13, 14], and hormone therapy might be a promising alternative for recurrent LGSC ...(androgen receptor ...
8
Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer
... microenvironment; AR: androgen receptor; AR-V7: androgen receptor splice variant 7; ADT: androgen deprivation therapy; PSA: prostate-specific antigen; AR-V: ...
10
Androgen Receptor as a Driver of Therapeutic Resistance in Advanced Prostate Cancer
... the androgen receptor (AR) signaling axis in the progression of prostate cancer is a cornerstone to our understanding of the molecular mechanisms causing castration-resistant prostate cancer ...ago, ...
8
Quality of life effects of androgen deprivation therapy in a prostate cancer cohort in New Zealand: can we minimize effects using a stratification based on the aldo-keto reductase family 1, member C3 rs12529 gene polymorphism?
... testicular androgen production for up to 97 % ...total androgen pool still remains in the serum after LHRH agonist treatment due to the existence of other androgen ...sources. Androgen is also ...
14
Urinary Oxalate Excretion Decreased in Androgen Receptor Knockout Mice by Suppressing Oxalate Synthesis in the Liver
... circulating androgen, and 95% of it is bound by sex hormone-binding protein ...to androgen recdeptor (AR), a nuclear receptor, which regulates androgen signaling ...of AR in ...
10
Targeting Androgen Receptor Aberrations in Castration-Resistant Prostate Cancer.
... active AR splice variants (AR-SV), of which AR splice variant 7 (AR-V7) has been reported to be the most abundant, have been postulated as critical for mCRPC biology and a key mechanism of ...
7
Precision medicine in breast cancer: reality or utopia?
... estrogen receptor; PgR: progesterone receptor; AR: androgen receptor; HER2: the oncogenic human epidermal growth factor receptor 2; PTEN: phosphatase and tensin homolog; PIK3CA: ...
13