Androgen receptor variant-7
Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.
... CRPC to date (11), is the AR-V7 (also termed AR3), which contains exons 1– 3 and 16 unique amino acids that arise from cryptic exon 3 (6). AR-V7 localizes constitutively to the nucleus, and facilitates AR-FL nuclear ...
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Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer.
... to androgen deprivation therapy, inevitably the majority progress to lethal metastatic castration-resistant PC (mCRPC) with main- tained androgen receptor (AR) ...
10
MED1 mediates androgen receptor splice variant induced gene expression in the absence of ligand
... when androgen ablation therapy ...the androgen receptor (AR), including production of intratumoral androgens, increased conversion of adrenal androgen to testosterone, and increased AR ...
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Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
... increased androgen receptor (AR) expres- sion and signaling despite AR ...splice variant in which exons 5, 6, and 7 are deleted (AR v567es ) and demonstrated that this variant can ...
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Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer
... HS data are reported as median values with interquartile range (IQR). Wilcoxon signed-rank and Mann-Whitney tests were used to compare differences in expression levels. Time to CRPC was defined as the time from diagnosis ...
10
Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer
... AR: androgen receptor; AR-V7: androgen receptor splice variant 7; ADT: androgen deprivation therapy; PSA: prostate-specific antigen; AR-V: androgen receptor ...
10
Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer.
... HS data are reported as median values with interquartile range (IQR). Wilcoxon signed-rank and Mann-Whitney tests were used to compare differences in expression levels. Time to CRPC was defined as the time from diagnosis ...
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LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models
... Intense interest currently surrounds the V7 splice variant of the AR which lacks a ligand (or enzalutamide) binding domain leaving a constitutively active N-termi- nal. AR-V7 expression represents a relatively ...
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The characteristics of androgen receptor splice variant 7 in the treatment of hormonal sensitive prostate cancer: a systematic review and meta-analysis
... The individual optimal therapy strategy of prostate cancer remains highly concern. Early combination of docetaxel to androgen deprivation therapy in hormone- sensitive metastatic prostate cancer indicated benefit ...
11
Androgen receptor splice variant 7 expression emerges with castration resistance in prostate cancer
... Since the pioneering studies of Huggins and Hodges in 1941, the androgen receptor has remained the focus of therapeutic targeting in CRPC. Inhibition of the AR axis with AA and E has improved both overall ...
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Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer.
... Since the pioneering studies of Huggins and Hodges in 1941, the androgen receptor has remained the focus of therapeutic targeting in CRPC. Inhibition of the AR axis with AA and E has improved both overall ...
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Food components and contaminants as (anti)androgenic molecules
... Flavonoids are widely present in fruits, vegetables, and beverages (tea, wine, beer) and in many dietary supple- ments and herbal remedies (Fig. 4). Quercetin (QRC) represents the most abundant dietary flavonoid found in ...
16
Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo
... equal amount of proteins, specifically fAR/AR-V7, in both control and treated groups, cells were treated for either 11 or 14 h with gal at 10 μM and total cell lysates analyzed prior to immunoprecipitation experiments ...
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Kinase mediated regulation of common transcription factors accounts for the bone protective effects of sex steroids
... sion of the protooncogenes c-fos or upregulates the activity of a reporter construct in MCF-7 human breast cancer cells via ER-mediated activation of the SRE through MAPK–dependent phosphorylation of Elk-1. ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... The androgen receptor (AR) is a key transcription factor in the initiation and progression of prostate cancer (PC) and is a major therapeutic target for the treatment of advanced ...elevated receptor ...
13
Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... The androgen receptor (AR) is a key transcription factor in the initiation and progression of prostate cancer (PC) and is a major therapeutic target for the treatment of advanced ...elevated receptor ...
13
An imaging agent to detect androgen receptor and its active splice variants in prostate cancer
... Unfortunately, approaches to determine if a patient harbors metastases that express AR-Vs are not developed or validated, with each approach having significant shortcomings. Measurement of AR-Vs in CTCs is dependent on ...
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Urinary Oxalate Excretion Decreased in Androgen Receptor Knockout Mice by Suppressing Oxalate Synthesis in the Liver
... The incidence of idiopathic calcium oxalate (CaOx) renal stone disease in men is 2.5 - 3 times higher than that in women [1] [2]. Although the reason for the gender disparity remains unclear, the several studies have ...
10
Recent advances on the progressive mechanism and therapy in castration-resistant prostate cancer
... 99. Botrel TE, Clark O, Lima Pompeo AC, et al. Efficacy and safety of com- bined Androgen Deprivation Therapy (ADT) and docetaxel compared with ADT alone for metastatic hormone-naive prostate cancer: a sys- ...
12
ARA55 in Cancers: A Double-Edged Sword
... Androgen receptor coactivator 55kDa protein (ARA55) was initially isolated and identified from mouse MC3T3-E1 osteoblasts treated with transforming growth factor-β1 ...
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