Androgen resistance
A mutation in the DNA binding domain of the androgen receptor gene causes complete testicular feminization in a patient with receptor positive androgen resistance
... Androgen resistance is associated with a wide range of quantitative and qualitative defects in the androgen ...of androgen resistance express normal quantities of apparently normal ...
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A single nucleotide substitution introduces a premature termination codon into the androgen receptor gene of a patient with receptor negative androgen resistance
... the androgen receptor that impair the action of 5 alpha-dihydrotestosterone and testosterone result in abnormal male sexual ...the androgen receptor gene has permitted us to examine its structure in nine ...
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Substitution of arginine 839 by cysteine or histidine in the androgen receptor causes different receptor phenotypes in cultured cells and coordinate degrees of clinical androgen resistance
... the androgen receptor gene with receptor phenotypes and with clinical phenotypes of androgen ...Their androgen receptor mutation changed arginine-839 to ...normal androgen-binding capacity, ...
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Functional analysis of androgen receptor mutations that confer anti androgen resistance identified in circulating cell free DNA from prostate cancer patients
... Genomic analysis of cfDNA is a minimally invasive method for interrogating mechanisms of therapeutic re- sistance in CRPC patients. In the present study, we dem- onstrate that cfDNA sequencing can identify mutations ...
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Reduced affinity of the androgen receptor for 5 alpha dihydrotestosterone but not methyltrienolone in a form of partial androgen resistance Studies on cultured genital skin fibroblasts
... basal androgen-receptor binding activity during prolonged incubation with ...the androgen receptor in her genital skin fibroblasts has a normal binding capacity (maximum binding capacity = 25 fmol/mg ...
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Molecular basis of androgen resistance in a family with a qualitative abnormality of the androgen receptor and responsive to high dose androgen therapy
... the androgen receptor were studied by introducing the changes, individually and in combination, into cDNAs encoding the normal human androgen receptor and analyzing the receptor protein produced after ...
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Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization
... to androgen resistance rather than to diminished androgen biosynthesis during fetal life, the effect of the administration of dihydrotestosterone to pregnant animals was studied in male, female, and ...
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Androgen-induced miR-135a acts as a tumor suppressor through downregulating RBAK and MMP11, and mediates resistance to androgen deprivation therapy
... The molecular mechanisms involved in the androgen-resistance transformation of PCa remained unclear. Emerging evidence had indicated that AR signaling plays a critical role in it [5]. Deregulation of miRNAs ...
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Complete testicular feminization caused by an amino terminal truncation of the androgen receptor with downstream initiation
... causing androgen resistance in two 46,XY siblings with complete testicular ...immunoreactive androgen receptor (AR) was detected in immunoblots using anti-NH2- terminal antibodies, suggesting an ...
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High efficiency covalent radiolabeling of the human androgen receptor Studies in cultured fibroblasts using dihydrotestosterone 17 beta bromoacetate
... affinity, saturable specific binding site for the ligand and was not detectable in cultured cells from a subject with androgen resistance or in receptor-negative nongenital fibroblasts. The efficiency of ...
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Syndromes d’insensibilite aux androgenes: Aspects moleculaires
... A mutation in the DNA-binding domain of the androgen receptor gene causes complete testicular feminiz- tion in a patient with receptor-positive androgen resistance.. Molecular bas[r] ...
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Polycystic Ovarian Syndrome: a new perspective
... increased androgen production was ...insulin resistance and hyperinsulinemia are also important components of PCOS that play a causal role in both hyperandrogenemia and chronic ...
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Integrating diet and exercise into care of prostate cancer patients on androgen deprivation therapy
... both androgen deprivation therapy (ADT) use and duration of exposure, and therefore to its associated adverse effects, such as sexual dysfunction, osteoporosis, reduced muscle mass, increased fat mass, and ...
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Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes
... chronic androgen excess using dihydrotestosterone (DHT) exhibit hyperinsulinemia and insulin resistance associated with secondary pancreatic b cell failure, leading to ...the androgen receptor (AR) ...
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Clinical and Hormonal Profile of Hypogonadism
... Drugs interfere with testicular function by several mechanisms, including inhibition of testosterone synthesis (e.g. ketoconazole), blockade of androgen action (eg.spironolactone), increased estrogen ...
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Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions
... To the extent that AR and AR splice variants are drivers of CRPC progression, mechanisms that repress their expression may lead to decreased cell growth. Studies by the Balk group have shown that AR gene expression is ...
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STATINS IN POLYCYSTIC OVARY SYNDROME
... have potential in the treatment of PCOS. A recent randomized prospective clinical trial evaluated the effects of simvastatin on women with PCOS. Simvastatin treatment reduced serum testosterone, normalized gonadotropins, ...
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Testosterone replacement in male hypogonadism
... Testosterone replacement is an effective method of treating hypogonadism in elder men, if used judiciously. An understanding of possible benefits and risks, judicious choice of the testosterone preparation, combined with ...
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Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer
... crine resistance in breast cancer has shown the develop- mental transcription factor HOXC11 to be a strong predictor of metastasis and poor disease-free survival (DFS), independent of receptor status, tumour size, ...
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Combined Androgen receptor blockade overcomes the resistance of breast cancer cells to palbociclib
... Enzalutamide is a second-generation AR antagonist and has been utilized for the treatment of patients with metastatic castration-resistant or chemotherapy-resistant prostate cancer. Enzalutamide has already entered ...
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