Ang-II
Disruption of the Ang II type 1 receptor promotes longevity in mice
... humans. Ang II is the central product of this system and is involved in regulating immune responses, inflammation, cell growth, and proliferation by acting through Ang II type 1 receptors (AT ...
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HIF-1α contributes to Ang II-induced inflammatory cytokine production in podocytes
... We next evaluated the effects of Ang II on HIF-1α ex- pression using immunohistochemistry. Almost no HIF- 1α expression was detected in the control group, whereas upregulation of HIF-1α was observed in ...
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Ang II–stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice
... Medial-to-intimal migration of SMCs is critical to atherosclerotic plaque formation and remodeling of injured arteries. Considerable amounts of the shed soluble form of the LDL receptor relative LR11 (sLR11) produced by ...
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A mouse model for Costello syndrome reveals an Ang II–mediated hypertensive condition
... renin–Ang II system. Treatment with captopril, an inhibitor of Ang II biosynthesis, prevented development of the hypertension condition, vascular remodeling, and heart and kidney ...
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Ets 1 is a critical regulator of Ang II mediated vascular inflammation and remodeling
... of the complex formed at 4 hours was verified by the fact that 10 ng of an unlabeled (cold) oligo- nucleotide was able to potently compete with the labeled probe (lane 6). Furthermore, when a mutant oligonucleotide in ...
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Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro
... Ang II transduces cell signaling upon binding to its re- ceptors, namely angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor ...of Ang II re- ceptors that ...
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Searching for transcriptional regulators of Ang II–induced vascular pathology
... Ang II plays a key role in cardiovascular regulation and participates in vascular pathobiology, including inflammation and ...direct Ang II actions or indirectly as a result of its influence ...
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NLRP3 inflammasome activation is involved in Ang II-induced kidney damage via mitochondrial dysfunction
... of Ang II in mitochondrial ...3A, Ang II induced mitochondrial ROS overproduction as compared with the ...attenuated Ang II- induced mROS overproduction (Figure ...that ...
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Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
... disease-related Ang II actions. In ApoE-KO mice, exogenous Ang II induced atherosclerosis and abdominal aortic aneurysm formation; we found that coinfusion of apelin abrogated these ...rescued ...
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PubMedCentral-PMC5646358.pdf
... urinary Ang II/Ang-(1–7), increased plasma Ang-(1–7), and decreased plasma Ang II/Ang- ...urinary Ang II/Ang-(1–7) among preterm adolescents exposed ...
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Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis
... kinase; Ang II: angiotensin II; AT1R: Ang II type 1 receptor; AT2R: Ang II type 2 receptor; CCM2: cerebral cavernous malformations 2; EC: endothelial cell; ECM: ...
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Effects of angiotensin II generated by an angiotensin converting enzyme independent pathway on left ventricular performance in the conscious baboon
... [Pro11DAla12] Ang I, a specific substrate for human chymase, was given in consecutive fashion as a ...an Ang II receptor antagonist. [Pro11DAla12]Ang I significantly increased LV systolic and ...
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Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway
... also attenuate migration induced by Ang II. Even though the mechanisms involved in DASMC proliferation and migration are not fully elucidated, a growing body of evidence suggests that calcium influx has an ...
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LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension
... angiotensin II (Ang II), which is converted from the inactive pro-hormone angiotensin I (Ang I) to the active peptide hormone Ang II by angiotensin-converting enzyme (ACE) ...
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Induction of platelet derived growth factor A chain and c myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells
... cycloheximide abolished the elevation of the PDGF A-chain mRNA. Taken together, our data show that exposure of RASM cells to Ang II results in the sequential activation of c-myc and PDGF A-chain mRNA ...
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The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments
... Angiotensin II (Ang II), as a vital mediator, could cause cardiac hypertrophy ...by Ang II and the mRNA ex- pressions of atrial natriuretic peptide (ANP), B-type natri- uretic peptide ...
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Endothelin 1 is an autocrine/paracrine factor in the mechanism of angiotensin II induced hypertrophy in cultured rat cardiomyocytes
... in ANG II-induced hypertrophy of neonatal rat cardiomyocytes by use of synthetic ET-1 receptor antagonist and antisense oligonucleotides to preproET-1 (ppET-1) ...well. ANG II upregulated ...
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The methanol seed extract of Garcinia kola attenuated angiotensin II- and lipopolyssacharide-inducedvascular smooth muscle cell proliferation and nitric oxide production
... All over the world, cardiovascular diseases are a risk factor for poor health and early death with predisposing factors to include age, gender, tobacco use, physical inactivity, excessive alcohol consumption, unhealthy ...
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Regulation of angiotensin II receptor AT1 subtypes in renal afferent arterioles during chronic changes in sodium diet
... of ANG II. Each recording was started when ANG II was introduced into the renal artery infusion ...of ANG II into the infusion line and the onset of the renal vascular ...
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Role of AT1 receptors in the resetting of the baroreflex control of heart rate by angiotensin II in the rabbit
... Angiotensin II (Ang II) resets the baroreflex control of heart rate to a higher blood ...via Ang II receptors in the area postrema, but it is not known if these are of the AT1 or AT2 ...
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