Animal Experiments
Systemic inflammation and microglial activation: systematic review of animal experiments
... Experimental studies have shown that peripheral chal- lenge with LPS causes a profound immunological re- sponse in the brain resulting in microglial activation, but systemic challenge with live bacteria causes microglial ...
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Alternatives to Animal Experiments: an Overview
... The use of animals for scientific experimental purposes has contributed a great deal to the advancement of biomedical knowledge and their continued use is essential for the continued understanding and maintaining the ...
6
Concept for the controlled plane wave exposure for animal experiments using a parabolic reflector
... Abstract. In this paper a low-cost concept for the controlled RF plane wave exposure for in vivo experiments is presented. The exposure setup is based on the use of a parabolic re- flector to convert the incident ...
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Volunteer studies replacing animal experiments in brain research - Report and recommendations of a Volunteers in Research and Testing workshop
... There has been little discussion of the role the ways in which questions are asked about of human volunteer studies in replacing and brain structure and function, and the kin[r] ...
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Bacterial Challenge Stimulates Formation of Arachidonic Acid Metabolites by Human Keratinocytes and Neutrophils In Vitro
... to experiments that demonstrated the synthesis of anti-inflammatory mediators by airway epithe- lial cells upon antigen stimulation in animal experiments and in vitro (25, 30, 35), the present ...
6
SYRCLE’s risk of bias tool for animal studies
... in animal intervention studies at present because protocols for animal studies are not yet registered in a central, publicly accessible ...all animal experiments at inception [19,20], so we ...
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Self expanding and balloon expandable stents in the treatment of carotid aneurysms: an experimental study in a canine model
... Animal experiments with stainless steel stents placed in the common carotid artery of dogs covering the origin of the internal carotid artery and smaller branches of the external carotid[r] ...
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The Alpha/Beta Interferon Receptor Provides Protection against Influenza Virus Replication but Is Dispensable for Inflammatory Response Signaling
... between animal genotypes (Cillo ´niz and Katze, ...these animal experiments can be ex- plained in part by the experiments with a homogeneous fibro- blast population devoid of signaling from ...
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Environmental and Occupational Risk Factors Effect to Arterial Hypertension: Correlation between Arterial Hypertension and Lead
... Both animal and human experiments have found a relationship between the levels of lead in the blood and the development of hypertension ...vitro experiments, acute lead poison- ing caused an increase ...
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The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments
... Although the above studies focused heavily on the mech- anism of NC via cell and animal experiments, there is a lack of information regarding the effects of NC in cardiac diseases at the molecular level. In ...
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Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review
... powered could be regarded as unethical, as the design is in- sufficient to answer the question the research is trying to address. It is important that the ethics in animal research and power are more fully ...
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Inhalation of specific anti-Pseudomonas aeruginosa IgY antibodies transiently decreases P. aeruginosa colonization of the airway in mechanically ventilated piglets
... Today, the foundation of treating VAP is the effective use of antibiotics, something that is increasingly difficult with the increasing presence of resistant bacteria. To main- tain the possibility of treating VAP caused ...
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Data Descriptor: Survival, gene and metabolite responses of Litoria verreauxii alpina frogs to fungal disease chytridiomycosis
... Experienced animal handlers followed routine rearing protocols under quarantine conditions in accordance with guidelines approved by Taronga Conservation Society Animal Ethics Committee ...experienced ...
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The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1
... HPMVECs were cultured in a DMEM high glucose growth medium with 10% FBS using American Type Culture Collec- tion guidelines. Simultaneously, 100 U/mL of penicillin and 100 U/mL of streptomycin were added to the growth ...
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Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review
... We included 39 experimental studies which used dis- tinct procedures to induce PCOS-like models of ovarian abnormalities and androgen excess, stratified into those using androgens [10–28], estrogens and endocrine dis- ...
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Energetic Cost of Generating Muscular Force During Running: A Comparison of Large and Small Animals
... The absence of any effect of load in our experiments on the stride frequency, average number of feet supporting the animal, or average vertical acceleration indicate that accelerations o[r] ...
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In vitro ADME Screening Instead of in vivo Studies in Preclinical Safety
... Using Computers in Various Basic Principles of Biology Computers have offered a platform by which the biological effects of candidate drugs or chemicals can be simulated independently of assessing animal ...
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Antitumor effects of inductive hyperthermia using magnetic ferucarbotran nanoparticles on human lung cancer xenografts in nude mice
... This study has several limitations. First, we only heated the tumors to 45 ° C to avoid thermal damage to other organs, particularly in an animal as small as the nude mouse. Therefore, the effects of induction ...
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Limitations of using synthetic blood clots for measuring in vitro clot capture efficiency of inferior vena cava filters
... conditions the larger PA hydrogel clots are not being cap- tured by the IVC filter, which is of concern since the clinical consequences of larger clots evading capture tend to be more serious than for smaller clots. ...
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Cerebellum and micturition: what do we know? A systematic review
... Sakakibara et al. [30] report a decrease of the tracer activ- ity in the bilateral upper vermis during the storage phase as compared with healthy controls. This decrease of activity is even wider in the micturition ...
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