Ankyrin repeat
The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum
... the ankyrin repeat-containing protein RARP-2, which in the avirulent Iowa strain contains a large internal deletion relative to the virulent Sheila Smith strain and possesses one nonsynonymous SNP not ...
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Designed Ankyrin Repeat Protein (DARPin) Neutralizers of TcdB from Clostridium difficile Ribotype 027
... designed ankyrin repeat proteins (DARPins) with ultrapotent neutralization activity against TcdB using phage display coupled with functional screening ...
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Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy
... Results: Previous studies suggest that neuropathy-causing mutations occur primarily at arginine residues on the convex face of the TRPV4 ankyrin repeat domain (ARD). Further highlighting the key role of ...
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Peptide array–based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase
... The ankyrin repeat (AR) domain of zDHHC17 (HIP14) and zDHHC13 (HIP14L) S-acyltransferases, which is involved in both substrate recruitment and S-acylation-independent functions, was recently shown to bind ...
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Chlorovirus Skp1-Binding Ankyrin Repeat Protein Interplay and Mimicry of Cellular Ubiquitin Ligase Machinery
... and ankyrin repeat (ANK) ...of ankyrin at C-terminal) ...ANK repeat proteins might form complexes analogous to the cellular Skp1-Cul1-F-box (SCF) ubiquitin ligase ...
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Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group
... of ankyrin repeat domain (ANK) encoding genes. Ankyrin repeats, consist- ing of around 33 residues, have been identified in a large number of proteins ...[8]. Ankyrin repeats are known to ...
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Conformation-Dependent Recognition of HIV gp120 by Designed Ankyrin Repeat Proteins Provides Access to Novel HIV Entry Inhibitors
... Here, we applied the designed ankyrin repeat protein (DARPin) technology to develop novel gp120-directed binding molecules with HIV entry-inhibiting capacity. DARPins are interesting molecules for HIV ...
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Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells
... Methods: We established two kinds of PEM-resistant mesothelioma cells which did not show any increase of the relevant enzyme activities. We screened genes enhanced in the PEM-resistant cells with a microarray analysis ...
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MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection
... present Ankyrin repeats (ANK) and a C-terminal PRANC domain [5]. The Ankyrin repeat, a 33-residue sequence domain, is one of the most common protein-protein interaction motifs found in nature ...
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Conserved Ankyrin Repeat Proteins and Their NIMA Kinase Partners Regulate Extracellular Matrix Remodeling and Intracellular Trafficking in Caenorhabditis elegans
... ABSTRACT Molting is an essential developmental process in nematodes during which the epidermal apical extracellular matrix, the cuticle, is remodeled to accommodate further growth. Using genetic approaches, we identified ...
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Role of distinct surfaces of the G9a ankyrin repeat domain in histone and DNA methylation during embryonic stem cell self-renewal and differentiation
... central ankyrin repeat domain (ANK, Figure 1A, top panel) results in impaired de novo DNA methylation of the Oct3/4 gene promoter during ESC differentiation ...
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Identification of a novel sequence motif recognised by the ankyrin-repeat domain of zDHHC17/13 S-acyl-transferases
... zinc finger DHHC (Asp-His-His-Cys)-containing domain (1–3). Based on this domain, several zDHHC enzymes (ranging from 7 to 24 per organism) have been identified and character- ized in various animal, parasite, and fungal ...
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Clinical significance of Ankyrin repeat domain 12 expression in colorectal cancer
... Ankyrin repeat domain 12 (ANKRD12), also called ANCO-2, is encoding a 224 kDa nuclear protein and most conserved at its N-terminal ankyrin repeats region and the C-terminal co-activator-interacting ...
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Ankyrin Repeat Proteins of Orf Virus Influence the Cellular Hypoxia Response Pathway
... FIG 4 The 1st ANK of ov008 is required for interaction with FIH. (A) The ankyrin repeat domain of ov008 was modeled using SWISS-MODEL and the human ankyrin-1 structure (PDB entry 1N11). Each ...
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<p>The KN Motif and Ankyrin Repeat Domains 1/CXXC Finger Protein 5 Axis Regulates Epithelial-Mesenchymal Transformation, Metastasis and Apoptosis of Gastric Cancer via Wnt Signaling</p>
... Recently, KN motif and ankyrin repeat domains 1 (KANK1) was veri fi ed as a suppressor in a variety of tumors. Yousif and colleagues indicated that high expression of KANK1 was associated with an improved ...
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Vaccinia Virus C9 Ankyrin Repeat/F-Box Protein Is a Newly Identified Antagonist of the Type I Interferon-Induced Antiviral State
... ABSTRACT Type I interferons (IFNs) induce expression of more than 300 cellular genes that provide protection against viruses and other pathogens. For survival, viruses evolved defenses to prevent the IFN response or ...
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M-T5, the Ankyrin Repeat, Host Range Protein of Myxoma Virus, Activates Akt and Can Be Functionally Replaced by Cellular PIKE-A
... by which PIKE-A rescues MV replication in previously non- permissive human cancer cells may provide additional clues to how M-T5 functions during MV infection. We predict that cells with a high level of PIKE-A expression ...
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Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
... form ankyrin repeat proteins which function as protein binders [11, ...natural ankyrin repeat proteins as alternative target-binding domains, libraries of artificial stacked ARs, called ...
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The enigmatic role of the ankyrin repeat domain 1 gene in heart development and disease
... the ankyrin repeat domain 1 (ANKRD1) factor (also known as CARP) plays a critical role in transcriptional regulation, myofibrillar assembly and stretch sensing during heart development and cardiac ...
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Ankyrin repeat and Single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs
... carcinogenesis. Ankyrin repeat and single KH domain 1 (ANKHD1) is a highly conserved protein found to interact with core cancer pathways in Drosophila, however its involvement in RCC is completely ...
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