Annexin A2
Expression and clinical significance of annexin A2 and human epididymis protein 4 in endometrial carcinoma
... In the preliminary study, a known protein annexin a2 was discovered as a binding partner of HE4 by mass spectrometry in ovarian cancer cells. We used co- immunoprecipitation assays and GST-pulldown to iden- ...
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Annexin A2 Mediates the Localization of Measles Virus Matrix Protein at the Plasma Membrane
... protein annexin A2 compromises the replication of MV within the ...that annexin A2 interacts with the MV M protein and mediates the localization of the M protein at the plasma membrane where ...
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Annexin A2-mediated cancer progression and therapeutic resistance in nasopharyngeal carcinoma
... Nasopharyngeal carcinoma (NPC) is a head and neck cancer with poor clinical outcomes and insufficient treatments in Southeast Asian populations. Although concurrent chemoradiotherapy has improved recovery rates of ...
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Targeting annexin A2 reduces tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma
... and neck carcinomas in terms of epidemiology, clinical presentations, biological markers, carcinogenic risk factors, prognostic factors, and treatment, and also in its near consistent association with the Epstein-Barr ...
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Annexin A2 is a novel Cellular Redox Regulatory Protein involved in Tumorigenesis
... Annexins are a structurally related family of calcium and phospholipid-binding proteins that are involved in the regulation of a wide range of molecular and cellular processes. Annexin A2 is unique among ...
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Three dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4 triazoles as inhibitors of the annexin A2 S100A10 protein interaction
... between annexin A2 and S100A10. Based on the binding pose of the annexin A2 N terminus in S100A10, a Markush carbonyl atom, hydrophobic and hydrogen bond interactions, along with spa- tial and ...
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Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2–dependent fibrinolysis
... The annexin A2 complex (termed “A2”) is the cell surface coreceptor for plasminogen and TPA and accel- erates the catalytic activation of plasmin, the major fibrinolytic agent in ...prevents ...
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Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant
... Annexin A2 (ANXA2) 4 is a broadly expressed member of the annexin family of calcium-dependent, anionic phospholipid-binding proteins. Annexins have homolo- gous core and carboxyl domains but variable ...
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Modulation of Vascular Endothelial Growth Factor and Annexin A2 in Response to 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone -Induced Inflammation via Swimming Training
... the annexin A2 inhibited the expression of proangiogenic molecules, including VEGF, leading to the inhibition of ...and annexin A2 in tumors seem to be a therapeutic ...
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Annexin A2 Is Involved in the Formation of Hepatitis C Virus Replication Complex on the Lipid Raft
... The hepatitis C virus (HCV) RNA replicates in hepatic cells by forming a replication complex on the lipid raft (detergent-resis- tant membrane [DRM]). Replication complex formation requires various viral nonstructural ...
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Annexin A2 binds to vimentin and contributes to porcine reproductive and respiratory syndrome virus multiplication
... Porcine reproductive and respiratory syndrome virus (PRRSV) is an important globally distributed and highly conta‑ gious pathogen that has restricted cell tropism in vivo and in vitro. In the present study, we found that ...
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Role of Annexin A2 in the Production of Infectious Hepatitis C Virus Particles
... Our colocalization analysis clearly revealed that NS5A was involved in the recruitment of ANXA2; still, we found no evidence for a direct interaction of the proteins. However, we cannot completely rule out a weak ...
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Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis
... protein annexin A2 to be regulated by ovarian cancer-peritoneal cell ...of annexin A2 in ovarian cancer metastasis and its potential utility as a novel therapeutic target, using in vitro and ...
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TRIM59 Is a Novel Marker of Poor Prognosis and Promotes Malignant Progression of Ovarian Cancer by Inducing Annexin A2 Expression
... In summary, increased TRIM59 expression in ovarian cancer tissues was positively associated with clinical parameters such as FIGO stages and metastasis due to the enhanced growth and extensive metastasis. Ovarian cancer ...
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Design, synthesis and SAR exploration of tri substituted 1,2,4 triazoles as inhibitors of the annexin A2–S100A10 protein interaction
... between annexin A2 and the S100A10 protein may have potential therapeutic benefits in ...the annexin A2–S100A10 protein interaction in competitive binding ...between annexin A2 ...
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Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells
... that Annexin A2 had an effect on regulating JNK phos- phorylation activation and subsequent cisplatin resist- ance in A549/DDP ...of Annexin A2, whereas p38MAPK phosphorylation was suppressed ...
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Annexin A2 Mediates Mycoplasma pneumoniae Community Acquired Respiratory Distress Syndrome Toxin Binding to Eukaryotic Cells
... ABSTRACT Mycoplasma pneumoniae synthesizes a novel human surfactant protein A (SP-A)-binding cytotoxin, designated community-acquired respiratory distress syndrome (CARDS) toxin, that exhibits ADP-ribosylating and ...
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen and Angiogenin Interact with Common Host Proteins, Including Annexin A2, Which Is Essential for Survival of Latently Infected Cells
... and annexin A2’s role in the survival of cells la- tently infected with ...si-annexin A2 on cell survival in the context of KSHV-infected cells is probably not just due to annexin ...
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Dendritic cells respond to nasopharygeal carcinoma cells through annexin A2-recognizing DC-SIGN
... Dendritic cells (DCs) play an essential role in immunity and are used in cancer immunotherapy. However, these cells can be tuned by tumors with immunosuppressive responses. DC-specific intercellular adhesion molecule ...
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Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies
... In this study, we showed that the ANXA2-expressing Listeria-based immunotherapy (Lm-ANXA2) prolonged survival in the mouse model of PDACs and the sequen- tial treatment with Lm-ANXA2 fol[r] ...
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