anti-angiogenic effects
Original Article Downregulating Notch-1-induced cytostatic and anti-angiogenic effects on trophoblast cells is associated with early spontaneous abortion
... DAPT treatment cells (Figure 3A, P < 0.001), and cell viability exhibited significant dose- dependent inhibitions after an increased con- centration of DAPT-treated for 72 h (P < 0.001). The inhibitory rate was ...
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Propranolol potentiates the anti-angiogenic effects and anti- tumor efficacy of chemotherapy agents: implication in breast cancer treatment
... the anti-proliferative and anti-angiogenic effects of chemotherapeutic drugs in vitro demonstrated in the current study provides two potential mechanisms by which propranolol may be able to ...
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Synthesis, Characterization and Anti Angiogenic Effects of Novel 5 Amino Pyrazole Derivatives on Ehrlich Ascites Tumor [EAT] Cells in Vivo
... In search of synthetic chemotherapeutic substances capable of inhibiting, retarding, or reversing the process of multi-stage carcinogenesis, we synthesized a series of novel 5-amino pyrazole derivatives 11(a-h) by a ...
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Anti tumor and anti angiogenic effects of Fucoidan on prostate cancer: possible JAK STAT3 pathway
... We treated DU-145 cells with different concentrations of fucoidan to assess its possible anti-angiogenic effects in vitro. 100, 200, 500 and 1000 μg/mL of fucoidan could inhibit viability of DU-145 ...
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Anti-angiogenic effects of biotechnological therapies in rheumatic diseases
... the anti-psoriatic effect of IBI303, an anti-TNF- α monoclo- nal antibody, based on the inhibition of both inflammation and angiogenesis, with a direct inhibition of the anti-TNF- α agent on blood ...
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Anti angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa
... These findings are in agreement with other studies in the literature, explaining the large effects of natural products in angiogenesis. A variety of herbs that are traditionally used for anticancer treatment also ...
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Resveratrol suppresses angiogenesis by down regulating Vegf/Vegfr2 in Zebrafish (Danio rerio) embryos
... their anti-angiogenic effects and found that resveratrol could disrupt major blood vessels in vivo through RBC ...showed anti-angiogenic and vascular-targeting activities using in vivo ...
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Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation
... their anti-tumor properties by activating 5’ adenosine monophosphate-activated protein kinase (AMPK), a key regulator of metabolism in cancer ...the anti-angiogenic effects of xanthohumol ...
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Murrangatin suppresses angiogenesis induced by tumor cell–derived media and inhibits AKT activation in zebrafish and endothelial cells
... between angiogenic and anti-angiogenic factors is thought to determine the extent of tumor ...its effects in a transgenic zebrafish ...direct anti-angiogenic ...different ...
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Cyclooxygenase-2 blockade can improve efficacy of VEGF- targeting drugs
... that anti-angiogenic therapies can induce upregulation of cyclooxygenase-2 (Cox-2) and of its product prostaglandin E2 (PGE 2 ) in breast cancer ...of anti- vascular endothelial growth factor ...
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Intravitreally injected anti-VEGF antibody reduces brown fat in neonatal mice
... C57BL/6 mice were obtained from Central Lab. Animal. OIR was induced in newborn mice as previously described [16,17]. At postnatal day (P)14, we intravitreally injected 1 μL of phos- phate-buffered saline (PBS) or ...
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Is inflammation the cause of pre-eclampsia?
... of angiogenic factors, and significantly decreased for each 2-fold elevation in circulating PlGF between 7 and 26 weeks of gestation ...of angiogenic factors was significantly higher in women with severe ...
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Pharmacological Activity of Andrographis Paniculata: A Brief Review
... Anti-malarial activity: Malaria is still prevalent disease in many tropical and subtropical countries. A. paniculata was found to considerably inhibit the multiplication of Plasmodium berghei, [11] one of the ...
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Pre eclampsia : predicting onset and poor outcome
... circulating angiogenic factors are altered in pre-eclamptic pregnancies up to five weeks before the onset of the clinical syndrome, many groups have aimed to identify “biomarkers” (biological markers) for ...
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Comparison of anti angiogenic properties of pristine carbon nanoparticles
... the anti- angiogenic properties of pristine carbon nanomaterials: diamond nanoparticles (ND), graphite nanoparticles (NG), graphene nanosheets (GNS), multi-wall nanotubes (MWNT) and C60 fullerenes ...
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The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia
... Soluble angiogenic factors expressed in the trophoblasts of the placenta, maternal decidua and macrophages stimulate capillary formation in the chorionic villi of the ...
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Recent Advances in Anti-Angiogenic Therapy of Cancer
... selective anti-angiogenic agents ...side effects of cytotoxic agents given in association metronomic chemotherapy should be considered both as novel up-front or maintenance treatment in patients with ...
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Maternal anti platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage
... of anti-platelet antibodies (40), although IVIG did not show antiidiotype activity and did not significantly inhibit the binding of anti-β3 antibodies to platelets ...
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Future options of anti-angiogenic cancer therapy
... available anti-angiogenic drugs contain an anti- vascular endothelial growth factor (VEGF) component as the primary target, and tumors may produce non-VEGF angiogenic factors to induce ...
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Maintenance chemotherapy in children with ALL exerts metronomic-like thrombospondin-1 associated anti-endothelial effect
... leukemia and MC has initially been demonstrated to be an antiangiogenic therapy [3]. Tumor angiogenesis can be easily and non-invasively monitored by analysis of circulating endothelial cells (CEC), endothelial ...
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