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ANTI-DIABETIC AND ANTI-OXIDANT PROPERTIES OF ALOE VERA IN ALLOXAN INDUCED DIABETIC RATS

ANTI-DIABETIC AND ANTI-OXIDANT PROPERTIES OF ALOE VERA IN ALLOXAN INDUCED DIABETIC RATS

ABSTRACT: The present study was undertaken to evaluate antidiabetic and antioxidant activities of Aloe vera (A. vera, Ghee- kuwar; family: Liliaceae) extract against alloxan-induced diabetes in male adult Charles foster rats to scientifically validate its use against diabetes. A. vera extract and a standard drug (glibenclamide) prepared in aqueous gum acacia (2%, w/v) suspension and fed orally to alloxan induced diabetic rats for 30 days. Biochemical parameters in normal, diabetic control, standard (600 µg/kg bw p.o.) and treated (1 g/kg bw p.o.) animals group were determined and compared. Treatment of alloxan-induced diabetic rats with A. vera extract showed a significant reduction (p<0.001) in blood glucose, lipid peroxide and significantly increased (p<0.001) superoxide dismutase, catalase, and protein. Furthermore, the extract (100-200 µg) when tested for its antioxidant activity in-vitro, showed significant (p<0.001) inhibition in the generation of superoxide anions and hydroxyl radicals. The results of the present study demonstrated anti-diabetic and anti-oxidant activities of A. vera extract which could help in the treatment of diabetes and related complications.
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  ANTI-DIABETIC EFFECT OF WRIGHTIA TINCTORIA EXTRACTS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

  ANTI-DIABETIC EFFECT OF WRIGHTIA TINCTORIA EXTRACTS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

and enhance its shelf life, without the need to refrigerate. The native practitioners in and around Chitoor District, India, have claimed that The leaves are used for treating diabetes (Madhava Chetty, 2008). Psoriasis, analgesic, anti-inflammatory, diuretic, and antinociceptive activities were reported (Mitra et al., 1998; Krishnamoorthy and Ranganathan, 2000; Chopra et al., 1956; Bigoniya et al., 2006). In previous study hypoglycemic and hypolipidemic activity of Wrightia tinctoria L. in alloxan induced diabetes in albino wistar rats was reported. Therefore the present studies to conform the anti-diabetic activity of Wrightia tinctoria L. in STZ induced diabetic rats model.
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EVALUATION OF ANTI DIABETIC ACTIVITY OF CORCHORUS TRILOCULARIS LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

EVALUATION OF ANTI DIABETIC ACTIVITY OF CORCHORUS TRILOCULARIS LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

ABSTRACT: The leaves of Corchorus trilocularis possesses several bioactivities and is used in traditional medicinal systems. However, its anti- diabetic activity has not been scientifically investigated so far. The present study was carried out to evaluate the anti-diabetic activity of chloroform extract extract of Corchorus trilocularis (family: Tiliaceae) leaves in Streptozotocin induced diabetic rats. Chloroform extract showed presence of saponins, phytosterols, flavonoids, phenols, steroids and terpenoids. From the toxicity study it was observed that chloroform extract of Corchorus trilocularis (CECT) was nontoxic up to the dose of 2000 mg/kg body weight. In this study, animals received continuous oral administration of CECT for a period of 21 days at the doses of 200 mg/kg and 400 mg/kg body weight. The effect of CECT was compared with oral dose of 5mg/kg Glibenclamide. The results showed that the CECT significantly lowered the blood sugar level of hyperglycemic rats in a dose dependent manner. CECT reduced glycosylated hemoglobin, lactate dehydrogenase and creatinine kinase levels in streptozotocin treated animals. The extract also ameliorated oxidative stress Parameters -TBARS, catalase and superoxide dismutase activity and glutathione content. In conclusion, the chloroform extract of Corchorus trilocularis leaves showed a significant anti-diabetic activity in streptozotocin induced diabetic rats possibly through increased secretion of insulin and the effect may be attributed to the presence of flavonoids and phenolic compounds present in extract.
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Anti-diabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats

Anti-diabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats

Methods: Male Wistar rats were divided in five groups (n=5 per group): normal control (NC), rats with STZ-induced diabetic mellitus (DM), diabetic rats administrated 0.4 g/kg body weight of SE (DM-SE 0.4) and 0.6 g/kg body weight of SE (DM-SE 0.6), and diabetic rats administrated 0.7 mg/kg body weight of glibenclamide (DM-G). Results: Administration of SE and G reduced the concentration of triglycerides, total and LDL-cholesterol and glucose, and the area under the curve of glucose during intraperitoneal glucose tolerance tests down to the levels observed in non-diabetic rats. In addition, administration of 0.4 and 0.6 g/kg SE and 0.7 mg/kg glibenclamide (G) significantly reduced the expression of phosphoenolpyruvate carboxykinase and the phosphor-p38/p38 ratio, while increased phosphor adenosine monophosphate activated protein kinase (AMPK)/AMPK ratio, but the glucose transporter 4 translocation and the phosphor-Akt/Akt ratio was significantly increased only by administration of G. Conclusions: These results indicate that the hypoglycemic effect of SE was related to hepatic gluconeogenesis but not the glucose uptake of skeletal muscle, and the effect was similar to that of anti-diabetic medication.
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EVALUATION OF ANTI DIABETIC AND ANTI HYPERLIPIDEMIC ACTIVITIES OF ETHANOLIC LEAF EXTRACT OF ORIGANUM MAJORANA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

EVALUATION OF ANTI DIABETIC AND ANTI HYPERLIPIDEMIC ACTIVITIES OF ETHANOLIC LEAF EXTRACT OF ORIGANUM MAJORANA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

ABSTRACT: Diabetes mellitus or sugar diabetes is a condition that occurs when the body can't use glucose (a type of sugar) normally. It is a chronic disease associated with abnormally high levels of the glucose in the blood because of disturbances in carbohydrates, fat and proteins metabolism and it is due to one of two mechanisms that inadequate production of insulin (which is made by the pancreas and lower blood glucose), or inadequate sensitivity of cells to the action of insulin. This causes glucose levels in the blood to rise, increased urination, extreme thirst and unexplained weight loss. The prominent objective of this work was to find out the anti-diabetic and anti-hyperlipidemic activities of Origanum majorana ethanol leaf extract (100, 200, 400 mg/kg body weight) in streptozotocin (50 mg/kg b.w) induced diabetic rats. After oral administration of such extract the blood glucose levels were recorded at specific intervals. In consequence it was observe that extract was significantly diminished blood glucose level. Simultaneously the effect of the extract on diabetes induced hyperlipidemia was studied where it markedly decreased the elevated total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) level while increased the high density lipoprotein (HDL). The preliminary phytochemical screening revealed the presences of tannins, glycosides, terpenoids, saponins, flavonoids and alkaloids. The conclusion exhibited that ethanol extract shows antidiabetic activity compared to standard drug glibenclamide (4 mg/kg). The further in-vivo study, isolation of pure phytoconstituents should be investigated to discover the antidiabetic action and other needful effects.
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FARMING ANTI-DIABETIC MEDICINAL PLANTS - AN UPDATE .......

FARMING ANTI-DIABETIC MEDICINAL PLANTS - AN UPDATE .......

Anti-diabetic activity: The possible mechanism by which plant extract brings about a decrease in blood sugar level may be by potentiation of the insulin effect of plasma by increasing either the pancreatic secretion of insulin from β cells of the islets of langerhans or its release from the bound form E. alba possesses a hypoglycemic effect may primarily by modulating and regulating the activities of glucose-6-phosphatase and fructose 1,6 biphosphatase enzymes either through regulation of cAMP or inhibition of gluconeogenesis. E. alba plants significantly decreased blood glucose level and showed anti- diabetic effect by suppressing carbohydrate absorption from the intestine 18 .
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Anti-diabetic Activity of Diplocyclos palmatus Linn. in Streptozotocin-Induced Diabetic Mice

Anti-diabetic Activity of Diplocyclos palmatus Linn. in Streptozotocin-Induced Diabetic Mice

The aim of present study was to investigate the anti-diabetic potential of methanolic extract of seed of Diplocyclos palmatus (MESDP), using STZ-induced diabetic mice model. Hyperglycaemia produced by STZ exhibited marked increase in serum triglycerides and total cholesterol. Under normal conditions, the enzyme lipoprotein lipase hydrolyses triglycerides. Diabetes mellitus results in failure to activate this enzyme thereby causing hypertriglyceridemia. Elevated serum total cholesterol, triglycerides and decreased high density lipoprotein level were observed in diabetic control mice. Chronic administration of the extract for 15 days to the STZ-induced diabetic mice significantly (p < 0.05) produced a fall in blood glucose level and lipid profile. Hence the methanolic extract may be considered to have good anti- hyperglycemic activity and did not cause any hypoglycemic effect unlike insulin and other synthetic drugs. Normalization of the blood glucose level resulted in significant reduction in the level of serum cholesterol and triglycerides. The anti- hyperglycemic activity caused by glibenclamide and MESDP in streptozotocin-induced diabetic mice indicates normalization of serum lipid profile and stimulation of insulin secretion from beta cells. The observed hypolipidaemic effect may be because of decreased cholesterogenesis and fatty acid synthesis. Significant lowering of total cholesterol and elevation of HDL cholesterol are very desirable biochemical states for prevention of atherosclerosis and ischemic conditions.
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Anti diabetic drug utilization of pregnant diabetic women in us managed care

Anti diabetic drug utilization of pregnant diabetic women in us managed care

Interestingly, according to the National Health Interview Survey, for the past ten years the prevalence of diabetic adults who do not use insulin or oral anti-diabetic drugs to control their diabetes has slightly grown by 1% to more than 15% of US adults with diabetes [2,21]. The fact that we observed even higher proportions of non-treated pa- tients in a managed care population with comprehensive drug benefits and increased medical attention due to preg- nancy is surprising and raises questions about current treatment approaches. While the majority of pregnant woman may have had onset of type 2 diabetes in recent years and thus limited need for aggressive glycemic con- trol, we still expected that current treatment guidelines and the emphasis on tight glucose control during preg- nancy would have resulted in more comprehensive drug therapy. Unfortunately, because laboratory values are not available in claims data, it is unclear whether these women were able to achieve or maintain normoglycemia through- out pregnancy.
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A Review on Fruits Having Anti Diabetic Potential

A Review on Fruits Having Anti Diabetic Potential

This paper has presented 50 anti-diabetic fruits which shows hypoglycemic activity. The most commonly studied plant families are Cucurbitaceae, Rutaceae, Solanaceae. Various secondary metabolites from fruits like triterpenes, flavonoids, sterols, coumarins, saponins, tannins, polysaccharides etc. have been exerting wide range of anti-diabetic activity. Thus successful results have been achieved by following an appropriate screening approach. More investigations must be carried out to evaluate the mechanism of action of medicinal plants with anti-diabetic effect.
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 EVALUATION OF ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITIES OF CINNAMOMUM TAMALA LINN LEAVES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

 EVALUATION OF ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITIES OF CINNAMOMUM TAMALA LINN LEAVES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Diabetes Mellitus (DM), is the most common endocrine chronic disorder caused by inherited and/or acquired deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced.. Such a deficiency results in increased concentrations of glucose in the blood, which in turn damage many of the body’s systems, in particular the blood vessels and nerves. The aim is to develop a scientifically validated and standardized herbal ration which will be useful in the treatment of diabetes. The main objective of this study was to focus on the anti-diabetic activity of Cinnamom tamala Linn, with special reference to its curative and protective role in streptozotocin- induced diabetic animal model. Attempts were then further made to study antioxidant properties of Cinnamom tamala Linn. leaves.
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Anti-Diabetic Effect of Flacourtia Jangomas Extract in Alloxan-Induced Diabetic Rats

Anti-Diabetic Effect of Flacourtia Jangomas Extract in Alloxan-Induced Diabetic Rats

The present study defines the systematic evaluation and effect of methanolic extract of Flacourtia jangomas (MEFJ) leaves and stem (1:1) in alloxan-induced diabetic rats. D iabetes was induced by an i.p. injection of single dose of alloxan monohydrate (120 mg/kg) in normal saline. Two days after alloxan injection, rats with blood glucose levels of >140 mg/dl were included in the study. Glibenclamide (5mg/kg) and extract (100mg/kg, 200mg/kg and 400mg/kg) were given orally. Treatment was continued for 14 consecutive days, with twice a day dose. Before the treatment (0 day) and after the treatment finally on 14 th day, blood samples were collected from the tip of the tail of each rat. Fasting blood glucose (FBG) level was estimated with the help of glucometer. MEFJ at the dose 400mg/kg produced highest significant reduction (39.42 %) in FBG as compare to other doses (100mg/kg and 200mg/kg) of MEFJ. Glibenclamide produced significant reduction in FBG level (44.68 %) which was highest as compare to all doses of F. jangomas extract. Thus it could be concluded that methanolic extract of F. jangomas possess significant anti-diabetic activity
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ANTI  DIABETIC ACTIVITY OF BRUGUIERA GYMNORHIZA ROOT

ANTI DIABETIC ACTIVITY OF BRUGUIERA GYMNORHIZA ROOT

In recent years many traditionally used medicinal plants have been tested for their antidiabetic potential in experimental animals. 10 Ethnobotanical information indicates that more than 800 plants are used as traditional remedies for the treatment of diabetes. 11 Many Indian medicinal plants are reported to be useful in diabetes. However, search for new anti- diabetic drugs continue. The roots of B.gymnorhiza Linn. (Family- Rhizophoraceae) were used traditionally for the treatment of diabetes. The present study is aimed at evaluating the antidiabetic activity of aqueous ethanol and butanol extract of B. gymnorhiza roots in alloxan induced diabetic rats. EXPERIMENTAL METHODS:
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MEDICINAL PLANTS AS NATURAL ANTI DIABETIC AGENTS

MEDICINAL PLANTS AS NATURAL ANTI DIABETIC AGENTS

have been used in the treatment of diabetes mellitus since the time of Charaka and Sushruta (6th century BC) 13 . The World Health Organization (WHO) has listed 21,000 plants which are used for medicinal purposes around the world. Among these, 2500 species are in India. There are about 800 plants which have been reported to show antidiabetic potential 14 . India is the largest producer of medicinal herbs endowed with a wide diversity of agro-climatic conditions and is called as botanical garden of the world 15 . Pharmacological and clinical trials of medicinal plants have shown anti- diabetic effects and repair of β-cells of islets of Langerhans 16 .
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ANTI-DIABETIC ACTIVITY OF FICUS NERVOSA LEAF IN ALLOXAN INDUCED DIABETIC RATS

ANTI-DIABETIC ACTIVITY OF FICUS NERVOSA LEAF IN ALLOXAN INDUCED DIABETIC RATS

Fasting blood glucose was determined after depriving food for 16 hrs with free access of drinking water. Hyperglycemia was induced by a single i.p injection of 120 mg/kg of alloxan monohydrate in sterile saline. after 5 days of alloxan injection, the hyperglycemic rats (glucose level>250 mg/dl)were separated and divided in to different groups comprising of 6 rats each for the anti-diabetic study. The treatment (p.o) was started from the same day except normal control and diabetic groups for a period of 10 days. During this period, animals in all groups had free access to standard diet and water. Body weight and blood glucose levels were estimated on 4 th ,
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Synthesis, Anti Tumor, Anti Diabetic, and Anti  Asthmatic Activitives of Some Novel Benzimidazole Derivatives

Synthesis, Anti Tumor, Anti Diabetic, and Anti Asthmatic Activitives of Some Novel Benzimidazole Derivatives

A series of novel substituted benzimidazole derivatives by the condensation of different diamines with anthranilicacid were synthesized. The subsequent reactions of the benzimidazole derivatives were reacted with different aromatic acid chlorides to get tetrazole moieties. These compounds were screened for their potential anti-cancer, anti-diabetic, anti-tumor and anti- asthmatic properties, which exhibited some authentic results towards testing organism invitro and invivo studies.

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Anti-diabetic potential of herbal medicinal plants

Anti-diabetic potential of herbal medicinal plants

mellitus is most typical type that was known previously as Non-Insulin Dependent Diabetes Mellitus (NIDDM), accounts for around 90% of all of the diabetes amongst different populations from the world. Currently used the majority of the oral hypoglycemic agents produce serious unwanted effects like hypoglycemic coma as well as hepatorenal disruptions. Hence look for safer and much more effective hypoglycemic agents. [Wild S et al, 2004].The medicinal use of plants is very old. The writings indicate that therapeutic use of plants is as old as 4000-5000 B. C. and Chinese used first the natural herbal preparations as medicines [Atal CK et al, 1989]. A wealthy heritage associated with knowledge upon preventive as well as curative medications was obtainable in ancient scholastic work contained in the Atharvaveda (an Indian native religious book), Ayurveda (Indian conventional system associated with medicine) and so forth. An estimate shows that about 13000 grow species globally are recognized to have already been used because drugs. [Gordon MC et al, 2001] Plant-based organic constituents could be derived through any the main plant such as bark, simply leaves, flowers, origins, fruits, seeds and so forth, that is actually any the main plant might contain energetic components. The advantageous medicinal results of grow materials typically derive from the combos of supplementary products contained in the grow. Many of these are accustomed to treat extremely prevalent condition diabetes mellitus. [Wink M, 2000] Some of the herbal drug which is used in our regular life style having anti diabetic activity. Some of them are briefed here.
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Formulation and Evaluation of Anti-Diabetic Inlay Tablets.

Formulation and Evaluation of Anti-Diabetic Inlay Tablets.

This is to certify that the work embodied in this thesis entitled, “FORMULATION AND EVALUATION OF ANTI-DIABETIC INLAY TABLETS” submitted to The Tamil Nadu Dr. M.G.R. Medical University, Chennai, was carried out by Reg. No. 26104207 in the Department of Pharmaceutics, Nandha College of Pharmacy and Research institute, Erode-52 for the partial fulfillment for the award of degree of MASTER OF PHARMACY in Pharmaceutics under the supervision and guidance of Dr.S.THAMIZARASI, M.Pharm., PhD., Head of the department, Department of Pharmaceutics, Nandha College of Pharmacy and Research Institute, Erode- 52.
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ANTI DIABETIC PROFILE OF CINNAMON POWDER EXTRACT IN EXPERIMENTAL DIABETIC ANIMALS

ANTI DIABETIC PROFILE OF CINNAMON POWDER EXTRACT IN EXPERIMENTAL DIABETIC ANIMALS

were treated orally with a daily dose of 50mg/kg, 100mg, 200mg, respectively for 30 days, for all diabetic rats after giving Test, NC, PC preparations, the blood samples were collected and determined the blood glucose level 0,1,3,24hrs intervals. 0hr reading is before drug giving and remaining 3 readings after drugs giving. 24 th her reading is considered as 0hr reading for the next day. Results: administration of alcohol of an extract of Cinnamomum zeylanicum produced a dose dependent decrease in blood glucose levels in Alloxan induced rats. There was significant fall in blood sugar level in High dose (200mg/kg) in comparison to low dose (50mg/kg) and median dose (100mg/kg) shown by LSD test. This is comparable to the effect of Glibenclamide. Conclusion: the results of this study show that chronic oral administration of an extract of Cinnamomum zeylanicum at an appropriate dosage may be good alternative anti diabetic agent .
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Anti-Diabetic Activity of Indian Hypericum Perforatum L. on Alloxan-Induced Diabetic Rats

Anti-Diabetic Activity of Indian Hypericum Perforatum L. on Alloxan-Induced Diabetic Rats

Anti-diabetic activity of the standardised extract of Indian Hypericum perforatum L. was investigated on alloxan induced diabetic rats. Indian Hypericum perforatum (IHp) extract was orally administered (100 and 200 mg/kg) as suspension in 0.3 % carboxy methyl cellulose for 14 days. Glibenclamide (10 mg/kg/day, p.o.) was used as standard. Blood samples were collected at day 0 and 14 th day (1 hour after last dose) from orbital sinus and blood glucose was estimated by commercially available kit. IHp treatment led to significant fall (p<0.01) in elevated blood glucose level. Moreover, IHp treatment also reverses the weight loss associated with alloxan treatment. The overall results indicate that IHp possess significant antidiabetic activity.
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Anti diabetic and anti oxidant potential of aged garlic extract (AGE) in streptozotocin induced diabetic rats

Anti diabetic and anti oxidant potential of aged garlic extract (AGE) in streptozotocin induced diabetic rats

Based on its acceptable palatability and milder side effects, content of potent bioactive components and conflicting reported effects in DM, the present study was carried out to assess the anti-diabetic potential of AGE by conducting an 8-week daily intraperitoneal (IP) three incremental dose–response study in STZ-induced diabetic rats. The doses investigated were selected based on a pilot study. In addition to examining the effect of AGE on the general indicators of diabetes, such as serum insulin and glucose, erythrocyte GHb, food and water in- take, urine output in addition to body weight changes, this study also looked at the indicators of OS and dyslipidemia to further delineate the scope of the anti-diabetic activity of this garlic preparation.
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