anti-double-stranded DNA
Interleukin-9 Is Associated with Elevated Anti-Double-Stranded DNA Antibodies in Lupus-Prone Mice
... saline, anti-IL-9 anti- body (100 μg/mouse), or anti-IL-19 anti- body (100 μg/mouse) plus anti-IL-17 an- tibody (100 μg/mouse), (eBioscience, San Diego, CA, USA) once every 4 wks for 12 ...
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Soluble receptor activator of nuclear factor κB ligand/osteoprotegerin ratio is increased in systemic lupus erythematosus patients
... Anti-dsDNA: anti-double stranded DNA; Anti-Sm: anti-Smith; BMD: bone mineral density; BMI: body mass index; CRP: C-reactive protein; EDTA: ethylenediamine tetraacetic ...
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Macrophage activation syndrome triggered by coeliac disease: a unique case report
... factor, anti-nuclear antibodies (ANA), anti-double- stranded DNA (anti-dsDNA), and anti-cyclic citrullinated peptide ...
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Elevated expression of TIGIT on CD3+CD4+ T cells correlates with disease activity in systemic lupus erythematosus
... anti double-stranded DNA; Anti-SSA: anti-SSA antigen; Anti-SSB: anti-SSB antigen; APC: antigen-presenting cells; C3: complement 3; C4: complement 4; CD40L: CD40 ...
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Biomarkers associating endothelial Dysregulation in pediatric-onset systemic lupus erythematous
... complexes, anti- endothelial cell antibodies, anti-double stranded DNA (dsDNA) antibodies; and the proinflammatory effect of various cytokines (eg, tumour necrosis factor (TNF-a) and ...
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Disease evolution in mixed connective tissue disease: results from a long term nationwide prospective cohort study
... for anti-RNP, anti-histidyl-tRNA syn- thetase (anti-Jo1), anti-Sjögrens Syndrome antigen A (anti-SSA) and B (anti-SSB), anti-centromere protein-B (ACA), ...
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High mobility group box 1 (HMGB1) and anti HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus
... in DNA-containing immune com- plexes that enhance cytokine production through TLR9 or RAGE ligation ...to anti-dsDNA antibodies (anti-double stranded DNA antibodies), antibodies ...
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Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study
... Results: The overall survival rate was 92.5% (37 of 40 patients). UC-MSCT was well tolerated, and no transplantation-related adverse events were observed. Thirteen and eleven patients achieved MCR (13 of 40, 32.5%) and ...
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Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
... ANA: Anti-nuclear antibodies; Anti- dsDNA ab: Anti-double-stranded DNA antibodies; Anti-ENA: Antibodies against extractable nuclear antigens; Anti-RNP: ...
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Increased levels of anti dsDNA antibodies in immune complexes before treatment with belimumab associate with clinical response in patients with systemic lupus erythematosus
... baseline anti-double-stranded DNA and anti-histone levels in immune complexes associated with attainment of zero scores in clinical systemic lupus erythematosus disease activity index ...
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Presence of antibodies against cyclic citrullinated peptides in patients with 'rhupus': a cross sectional study
... for anti-CCP antibodies, rheumatoid factor, antinuclear antibodies, anti-extractable nuclear antigens, and antibodies against double-stranded DNA ...
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Deoxyribonucleic acid strandedness Partial characterization of the antigenic regions binding antibodies in lupus erythematosus serum
... for anti-DNA by hemagglutination bind significantly less to the alkaline fraction DNA than the sale fraction ...for double-stranded vs. single-stranded nucleic acid since the ...
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Development of physical forms of unintegrated retroviral DNA in mouse spinal cord tissue during ts1-induced spongiform encephalomyelopathy: elevated levels of a novel single-stranded form in paralyzed mice.
... linear double-stranded viral DNA (49) that either integrates into the chromosomal DNA or circularizes ...unintegrated DNA, HM, was identified in the CNS of mice that were infected with ...
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Review article: BK virus in systemic lupus erythematosus
... The precise mechanism of BKV transmission has yet to be determined; however, various routes have been im- plicated, such as: fecal-oral, respiratory, and organ transplantation [5]. Once acquired, the mechanism of dormant ...
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In-/off-label use of biologic therapy in systemic lupus erythematosus
... Different facts can explain the failure of these phase III RCTs testing CD-20 depleting agents in SLE, for example, the low number of patients, highly variable background of immunosuppressive therapy and high dose ...
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Hepatitis B Viral DNA Molecules Have Cohesive Ends
... HBV DNA with the single-stranded region made completely double stranded by the virion DNA polymerase was made linear by heating and incubated in a reverse transcriptase reaction containi[r] ...
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Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study
... Recent findings have linked TWEAK to renal inflammation in an animal model of SLE [13,24], and on this premise we hypothesized that excreted uTWEAK may denote the pres- ence and activity level of LN in SLE patients. ...
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Rapid and simple method for purification of nucleic acids
... By using size-fractionated silica particles, nucleic acids covalently closed circular, relaxed circular, and linear double-stranded DNA; single-stranded DNA; and rRNA could be purified f[r] ...
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Why Is DNA Double Stranded? The Discovery of DNA Excision Repair Mechanisms
... of DNA repair are convinced that “This situation did little to endear the community of radiobiologists to the ‘aristocrats’ of molecular biology, who not only labored under more restrictive financial conditions, ...
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In vitro synthesis of double-stranded DNA from the Kilham rat virus single-stranded DNA genome.
... SALZMAN,* PHYLLIS FABISCH, RONALD PARR, CLAUDE GARON, AND TONU WALI Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014 Doub[r] ...
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