anti-fibrotic
HGF and IL-10 expressing ALB::GFP reporter cells generated from iPSCs show robust anti-fibrotic property in acute fibrotic liver model
... administration of IL-10 has been shown to decrease inflammatory factors and suppress the apoptosis of hepatocytes [34, 35]. In line with these reports, trans- plantation of IL-10 expressing iHep cells was seen to ...
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Anti inflammatory/anti fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni induced liver fibrosis
... potent anti-inflammatory, immunomodulatory and anti- fibrogenic agent in the liver ...its anti-inflamma- tory/anti-fibrotic effects alone and with the anti-schisto- somal PZQ, on ...
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Anti-fibrotic, anti-VEGF or radiotherapy treatments as adjuvants for pterygium excision: a systematic review and network meta-analysis
... of anti-VEGF treatment agents such as bevacizumab (avastin) and rani- bizumab (lucentis) have been evaluated in primary and re- current ...such anti- fibrotic or anti-VEGF medications is not ...
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Anti fibrotic action of pirfenidone in Dupuytren’s disease derived fibroblasts
... its anti- fibrotic and anti-inflammatory properties in a variety of pre-clinical and in vitro models in different organs, including fibrosis of the lung [23], kidney [24], heart [25], liver [26], and ...
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Anti fibrotic effects of phenolic compounds on pancreatic stellate cells
... potent anti-fibrotic effect as it significantly ame- liorated the severity of pancreatic fibrosis in the course of chronic pancreatitis in vivo [4] and inhibited the production of fibrogenic mediators in ...
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The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma
... GV1001 is a telomerase-based cancer vaccine made of a 16-mer telomerase reverse transcriptase (TERT) peptide, and human TERT, the rate-limiting subunit of the telomerase complex, is an attractive target for cancer ...
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Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity
... We investigated whether nintedanib reduces the number of fibrocytes in a mouse model of BLM-induced pul- monary fibrosis. Mice received a single transbronchial instillation of BLM on day 0. After the administration of ...
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Anti fibrotic effect of Holothuria arenicola extract against bile duct ligation in rats
... become attractive as nutraceutical and functional foods and as a source material for the development of drugs [17]. Sea cucumber Holothuria is a gelatinous marine resource that is shaped as a cucumber. It is considered ...
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Ruscogenin ameliorates diabetic nephropathy by its anti inflammatory and anti fibrotic effects in streptozotocin induced diabetic rat
... Background: Ruscogenin is a major steroid sapogenin in the traditional Chinese herb Ophiopogon japonicus that have multiple bioactivities. Recent studies have demonstrated that ruscogenin is involved in down-regulation ...
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Deletion of Osteopontin Enhances b2-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes
... signaling, including 2 AR-induced cAMP production, in H9c2 cardiomyocytes. Epac1 upregulation by OPN CRISPR-mediated deletion in H9c2 cardiomyocytes 158[r] ...
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Anti-Fibrotic Potential of Nicorandil in the Treatment of Bleomycin Induced Pulmonary Fibrosis
... The preventive effect of nicorandil may reflect the reduction in the migra- tion of neutrophils and other inflammatory cells in the inflamed region, thereby mitigating tissue damage in the lung. The possible mechanism ...
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Anti-fibrotic effect of Smad decoy
... liver sinusoid increased in CCl 4 -induced fibrosis mice, whereas administration of Smad decoy 130.. suppressed fibronectin expression (Fig 2D)..[r] ...
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Gamma Linolenic Acid Exerts Anti Inflammatory and Anti Fibrotic Effects in Diabetic Nephropathy
... For immunohistochemical staining, slices of kidney were snap-frozen in optimal cutting temperature solution and 4 μm sections of tissues were utilized. Slides were fixed in acetone for 10 minutes, air dried at room ...
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Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development
... The discovery and characterization of fibrosis-promoting molecules or pathways in HSCs have provided new insights into treating liver cirrhosis [1, 11, 12]. Small molecule drugs are being developed to target activated ...
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Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway
... (MSCs) to reduce liver fibrosis and improve liver function [4 – 6]. Different sources of MSCs have highlighted the anti-fibrotic potential of this cell type in animal models [7 – 9]. In addition, clinical ...
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C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice
... of fibrotic foci [8, ...the fibrotic changes in BLM-injured ...vivo anti-fibrotic effect of CNP might be exerted via lung fibroblasts by disturbing the TGF-β–mediated transformation of lung ...
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Artesunate may inhibit liver fibrosis via the FAK/Akt/β-catenin pathway in LX-2 cells
... the anti-fibrogenic properties of Artesunate ...the anti-fibrotic effects of ART on LX-2 cells, the human HSC cell line, and to determine potential molecular mechanisms via the focal adhesion kinase ...
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Brimonidine reduces TGF-beta-induced extracellular matrix synthesis in human Tenon’s fibroblasts
... topical anti-glaucoma eyedrops were highly proliferative and had elevated TGF-β expression compared to cells isolated from control ...the anti-glaucoma medications changed the expression levels of matrix ...
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Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy
... of anti-inflammatory and immunosuppressive treatment modalities, the aberrant wound healing processeses rep- resented by the formation of fibroblastic foci (FF) are recognized to be responsible for fibrotic ...
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Effect of simvastatin on the transforming growth factor β1, fibroscan scores, and aspartate transaminase to platelet index ratio patients with Liver Cirrhosis
... have anti- fibrotic effects of hepatic better than fluvastatin (lukisvaya et al, ...no anti-fibrotic effect on rat models of cirrhosis (Shirin et al, ...
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