Anti-fibrotic effect
Anti-Fibrotic Effect of Irbesartan via Attenuation of Endoplasmic Reticulum stress in Isoprenaline-Induced Myocardial Fibrosis
... cardioprotective effect of irbesartan in isoproterenol induced endoplasmic reticulum stress, which results in myocardial ...possesses anti-fibrotic activity and offers protection against myocardial ...
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Anti-fibrotic effect of Smad decoy
... liver sinusoid increased in CCl 4 -induced fibrosis mice, whereas administration of Smad decoy 130.. suppressed fibronectin expression (Fig 2D)..[r] ...
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Anti fibrotic effect of Holothuria arenicola extract against bile duct ligation in rats
... become attractive as nutraceutical and functional foods and as a source material for the development of drugs [17]. Sea cucumber Holothuria is a gelatinous marine resource that is shaped as a cucumber. It is considered ...
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The anti-fibrotic effect of human fetal skin-derived stem cell secretome on the liver fibrosis
... In our previous study, we have successfully isolated and identified hFSSCs [13]. Interestingly, we found hFSSC secretome has great ability to control and bal- ance the collagen formation in skin tissue [13]. Therefore, ...
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Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung
... Three systems were used to assess fibrosis on Haema- toxylin & Eosin and Masson’s trichrome stained lung sections (5 μm thick) (see Fig. 1b) [20, 21]. The first scoring system was used to determine the extent of the ...
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Transcriptional regulation of matrix metalloproteinase 1 and collagen 1A2 explains the anti fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts
... the effect of bortezomib on type I collagen synthesis is mediated, at least in part, by its capacity to reduce SP1 binding to the promoter of ...an effect of bortezomib on canonical Smad signaling in ...
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The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma
... the effect of telomerase peptide vaccination, GV1001 combined with gemcitabine in treatment of pancreatic ductal adenocarcinoma ...GV1001 effect combined with gemcitabine treatment may give us useful ...
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Anti fibrotic effects of phenolic compounds on pancreatic stellate cells
... potent anti-fibrotic effect as it significantly ame- liorated the severity of pancreatic fibrosis in the course of chronic pancreatitis in vivo [4] and inhibited the production of fibrogenic ...
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Brimonidine reduces TGF-beta-induced extracellular matrix synthesis in human Tenon’s fibroblasts
... topical anti-glaucoma eyedrops were highly proliferative and had elevated TGF-β expression compared to cells isolated from control ...the anti-glaucoma medications changed the expression levels of matrix ...
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Effect of simvastatin on the transforming growth factor β1, fibroscan scores, and aspartate transaminase to platelet index ratio patients with Liver Cirrhosis
... an anti-fibrotic liver has not been done using markers TGF β1, FibroScan score, and APRI score as a marker of liver ...has anti-fibrotic effect on liver cirrhosis in which the research ...
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C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice
... vasoprotective effect of CNP could result partially in the attenuation of inflamma- tory cell infiltration induced by BLM via reduction of ad- hesion ...once fibrotic change occurs, fi- broblasts and ...
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Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation
... TAA causes toxicity in hepatocytes and then induces acute and chronic liver injury through free radical and oxidative stress [24]. The first step of TAA metabolism is through flavin-adenin dimucleotide (FAD)-containing ...
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Ruscogenin ameliorates diabetic nephropathy by its anti inflammatory and anti fibrotic effects in streptozotocin induced diabetic rat
... Background: Ruscogenin is a major steroid sapogenin in the traditional Chinese herb Ophiopogon japonicus that have multiple bioactivities. Recent studies have demonstrated that ruscogenin is involved in down-regulation ...
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Anti-fibrotic, anti-VEGF or radiotherapy treatments as adjuvants for pterygium excision: a systematic review and network meta-analysis
... an anti-proliferation agent, such as MMC (n = 1007), 5-FU (n = 238), β-RT (n = 123), or the anti-VEGF agent bevacizumab (n = 366) to prevent recur- rence after pterygium ...
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Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development
... promoted the myofibroblast differentiation of HSCs, as indicated by the increased expression of α -SMA (Fig. 1A). Thus, we next determined whether MAPK activation mediated HSC differentiation. As shown in Fig. 1B, ...
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Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy
... with Anti-rabbit IgG, HRP- linked secondary antibody (Cell Signaling Technology, # 7074), Anti-mouse IgG, HRP-linked secondary antibody, # 7076) or Anti-goat IgG (H + I), HRP-linked secondary ...
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Deletion of Osteopontin Enhances b2-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes
... signaling, including 2 AR-induced cAMP production, in H9c2 cardiomyocytes. Epac1 upregulation by OPN CRISPR-mediated deletion in H9c2 cardiomyocytes 158[r] ...
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Anti inflammatory/anti fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni induced liver fibrosis
... stabilizing effect on the cytoplasmic ...potent anti-inflammatory, immunomodulatory and anti- fibrogenic agent in the liver ...the effect of silymarin treat- ment in experimental ...
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A monoclonal antibody to the carboxyterminal domain of procollagen type I visualizes collagen synthesizing fibroblasts Detection of an altered fibroblast phenotype in lungs of patients with pulmonary fibrosis
... Excessive collagen deposition plays a critical role in the development of fibrosis, and early or active fibrosis may be more susceptible to therapeutic intervention than later stages of scarring. However, at present ...
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Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells
... phosphatase anti-alkaline phosphatase method with goat anti-human collagen type I polyclonal (CHEMICON, Temecula, CA), mouse anti-human HSP47 (Stressgen, Victoria, Canada) and mouse anti- ...
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