anti-HIV-1 effect
Dual role of α defensin 1 in anti–HIV 1 innate immunity
... a-defensin-1–mediated HIV-1 inhibition. a-Defensin-1 had a direct effect on HIV-1 virions at a low MOI in the absence of ...direct effect on HIV-1 ...
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Generation of Rhesus Macaque-Tropic HIV-1 Clones That Are Resistant to Major Anti-HIV-1 Restriction Factors
... negative effect on viral replication is certainly observed in cul- tured cell lines and primary cells but is not so evident relative to those of APOBEC3 and TRIM5 proteins ...of HIV-1mt clones to antagonize ...
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The effect of HIV 1 Vif polymorphisms on A3G anti viral activity in an in vivo mouse model
... Fig. 1 a Top a plasmid encoding the full‐length replication‐competent clone Friend MLV was modified by adding a 2A peptide sequence (P2A) from picornaviruses, in frame with the C terminus of the envelope gene, ...
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Neutralizing antibodies against the V3 loop of human immunodeficiency virus type 1 gp120 block the CD4-dependent and -independent binding of virus to cells.
... type 1 (HIV-1) through high-affinity interactions with the viral external envelope glycoprotein ...block HIV infection without affecting the binding of HIV particles to CD4-expressing ...
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Mechanisms of human immunodeficiency virus Type 1 (HIV-1) neutralization: irreversible inactivation of infectivity by anti-HIV-1 antibody.
... of HIV-1 is associated with the induction of shedding of gp120 from virions, although it is not clear that the shedding phenomenon is a cause or concomitant of inactivation (39, ...shedding, ...
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SYNTHESIS, ANTI VIRAL AND CYTOTOXICITY STUDIES OF SOME NOVEL N SUBSTITUTED BENZIMIDAZOLE DERIVATIVES
... Assay: Anti HIV Assay compounds were tested for their inhibitory effects against replication of HIV-1 (IIIB) and HIV-2 (ROD) in MT-4 cells 2 ...Inhibitory effect of test ...
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beta estradiol attenuates the anti HIV 1 efficacy of Stavudine (D4T) in primary PBL
... the effect of different concentrations of β- estradiol on D4T efficacy suggests that the reduction in efficacy titers over physiologically active levels of β-estra- diol (Figure ...no effect of progesterone ...
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Lack of enhancing effect of human anti-human immunodeficiency virus type 1 (HIV-1) antibody on HIV-1 infection of human blood monocytes and peritoneal macrophages.
... Because HIV antibody-positive human sera have been shown to enhance HIV-1 infection of MT-2 cells when tested in the presence of complement 40-43, 45, we looked for a similar effect of c[r] ...
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Regulation of Human Immunodeficiency Virus Replication by 2′,5′-Oligoadenylate-Dependent RNase L
... The anti-HIV effects of the 2-5A system are probably due to the stimulation of 2-5A synthetase activity by highly structured regions of HIV ...of HIV RNA is sufficiently double stranded to ...
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Broad, Intense Anti-Human Immunodeficiency Virus (HIV) Ex Vivo CD8+ Responses in HIV Type 1-Infected Patients: Comparison with Anti-Epstein-Barr Virus Responses and Changes during Antiretroviral Therapy
... plasma HIV RNA to undetectable ...of HIV infec- tion confirm similar observations made in studies using a clas- sical chromium release test after in vitro stimulation among a large cohort of seroconverters ...
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Contribution of oligomerization to the anti HIV 1 properties of SAMHD1
... spectrum with the signal of the H8 proton of the guanine base. The peak is shifted from 8.04 ppm to 7.92 ppm upon hydrolysis of dGTP to deoxyguanosine. The three spectra were collected 4, 160 and 344 min after addition ...
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An anti-lymphocytic choriomeningitis virus ribozyme expressed in tissue culture cells diminishes viral RNA levels and leads to a reduction in infectious virus yield.
... Ribozymes have been shown to exert a limited effect on one animal virus, the human retrovirus human immunodeficiency virus type 1 HIV-1, in cell culture; an anti-HIV-1 anti-gag ribozyme [r] ...
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99005.2-20180920142741-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf
... rescues anti–HIV-1 T cell responses and reduces the size of the HIV-1 ...persistent HIV-1 infection in hu-mice led to T cell tolerance, and cART treatment rescued the ...
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“(Cyclohexyl Methylene) Bis-Diacyl Phloroglucinol: An Inhibitor of HIV-1 Integrase In Vitro” by Sudeep Sabde, Debashis Mitra, Sanjay Toshniwal, India.
... exhibits anti-HIV activity in TZMbl tissue culture only if preincubated with virus and added after infection of target ...whether 1 must enter the cell with the virus or whether intgrase must be ...
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Evolution of subtype C HIV 1 Env in a slowly progressing Zambian infant
... infant anti- HIV-1 humoral immunity, we analyzed neutralization of infant 6-month, 12-month and 48-month viral isolates by contemporaneous and non- contemporaneous plasma (Figure ...a 1:20 ...
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A new antisense tRNA construct for the genetic treatment of human immunodeficiency virus type 1 infection.
... predicted by computer analysis, do not significantly interfere with this process. More importantly, results for the infected cells confirm that the RNA pairing observed in vitro and an- ticipated by an RNA folding ...
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Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo
... to HIV-1 gp120 protein (consensus sequence protein for clade A1; Immune Technology ...of HIV-1 gp120 protein (Con_A1; Immune Technology ...for 1 h at room temperature (RT) or overnight ...
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Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody That Recognizes a Novel Conformational Epitope on gp41 and Lacks Reactivity against Self-Antigens
... an HIV-1 Env-pseudotyping system and TZM-bl target cells containing a tat-inducible luciferase reporter and expressing CD4, CCR5, and ...the effect of target cells on antibody neutralization ...
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Antigen-Dependent and -Independent Mechanisms of T and B Cell Hyperactivation during Chronic HIV-1 Infection
... in anti- gen-dependent stimulation of non-HIV-specific T cells dur- ing chronic HIV infection, we would like to introduce sev- eral possible sources of antigenic stimulation which have been discussed ...
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Rapid Detection and Differentiation of Antibodies to HIV-1 and HIV-2 Using Multivalent Antigens and Magnetic Immunochromatography Testing
... rapid HIV tests has now become routine in many areas of the world due to their simplicity, low cost, and excel- lent performance characteristics (8, ...rapid HIV assays are now approved by the ...with ...
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