anti-IL-17
Heterogeneous expression pattern of interleukin 17A (IL 17A), IL 17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti IL 17 therapy?
... increased IL-17A expression in synovial tis- sues from inflammatory arthritis patients compared with noninflamed control synovium, supporting the concept that IL-17 is a key cytokine in chronic ...
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Association of CD4+ CD25+ T Cells with Prevention of Severe Destructive Arthritis in Borrelia burgdorferi-Vaccinated and Challenged Gamma Interferon-Deficient Mice Treated with Anti-Interleukin-17 Antibody
... with anti-interleukin-17 (IL-17) antibody, the number of CD4 ⴙ CD25 ⴙ T cells increased in the local lymph ...these anti-IL-17-treated ...administered anti-CD25 ...
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IL 17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
... addition, IL-17 dose-dependently induced expression of osteoclast differentiation factor (ODF) mRNA in ...inhibited IL- 17–induced osteoclast differentiation in the ...of IL-17 ...
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Effector mechanisms of interleukin 17 in collagen induced arthritis in the absence of interferon γ and counteraction by interferon γ
... with anti-IL-17 antibodies Pathogenesis of CIA is generally considered to depend in part on both humoral and cellular immune responses against ...by anti-IL-17 antibodies results ...
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A polymorphism in the interleukin 4 receptor affects the ability of interleukin 4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis
... biotinylated anti-IL-17 antibody and the detection reagent streptavidin horseradish per- oxidase were added to each well and incubated at room temperature for 2 ...
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IL 23 induces human osteoclastogenesis via IL 17 in vitro, and anti IL 23 antibody attenuates collagen induced arthritis in rats
... that IL-23 directly induced human osteoclastogenesis in cultures of PBMC in the absence of osteoblasts or exogenous ...whether IL-23 induces osteoclastogenesis from human monocytes alone; however, rhIL-23 ...
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The role of T cell interleukin 17 in conducting destructive arthritis: lessons from animal models
... for IL-17 is not fully identified; however, IL-23 promotes the production of IL-17 and a strong correlation between IL-15 and IL-17 levels in synovial fluid has ...
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The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia
... of IL-17 in the lungs caused by IL-23 deficiency or by neutralizing anti-IL-17 antibody resulted in transient decrease (three weeks after infec- tion) in clearance of ...
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IL 32 and IL 17 interact and have the potential to aggravate osteoclastogenesis in rheumatoid arthritis
... of IL-17, which caused IL- 32 expression in FLSs. This IL-32 induction was par- tially inhibited by blocking with anti-IL-17 antibodies (Figure ...the ...
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Anti–IL 23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
... Anti–IL-23 therapy during disease remission inhibits CNS expres- sion of proinflammatory cytokines and prevents EAE relapse. (A) Average clinical score of mice given the first treatment dose of ...
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TSC1 regulates the balance between effector and regulatory T cells
... with anti-CD3 and ...and IL-4 or IL-17A showed that cytokine production from the Th1 and Th17 sub- sets was substantially increased under polarizing conditions in TSC1-deficient T cells (Figure ...
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The role of inflammasome derived IL 1 in driving IL 17 responses
... where IL-1 or IL-18 is directly involved in inflammatory pathology, and evidence is emerging that they may also play a crucial role in diseases me- diated by IL-17-producing T ...human ...
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Low magnitude of tensile stress represses the inflammatory response at intervertebral disc in rats
... of IL-17 and ...the anti-inflammatory role in the envir- onment of ...of IL-17 and IL-1β but also mRNA expressions of IL-17 and ...
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Oestrogen receptor negative breast cancers exhibit high cytokine content
... screened 17 members of the cytokine family (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL- 10, IL-12 [p70], IL-13, IL-17, ...
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Association of periodontitis with rheumatoid arthritis and atherosclerosis: Novel paradigms in etiopathogeneses and management?
... lineages. IL-17 is known to contribute to bone loss in RA and severe periodontal disease, and also plays an essential role in host defenses against pathogens that are susceptible to polymor- phonuclear ...
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Anti tumor necrosis factor modulates anti CD3 triggered T cell cytokine gene expression in vivo
... gamma, IL-3, IL-4, and IL-6 genes was initiated rapidly by treatment of mice with ...26-kD anti-TNF-reactive protein compatible with membrane-anchored ...with anti-TNF did not affect ...
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IL 17 and IL 22 production in HIV+ individuals with latent and active tuberculosis
... Forty patients with acid-fast smear, and culture-confirmed active pulmonary tuberculosis (ATB), with no history of anti-tuberculosis therapy seropositive to HIV were enrolled. Forty HIV patients with latent TB ...
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Impact of Smoking on the IL-1Β, IL-8, IL-10, IL-17 and TNF-α Production in Chronic Periodontitis Patients
... understood. IL-17 is a pro-inflammatory cytokine and the prototype cytokine for a subset of Th17 cells (Gaffen and Hajishengallis, ...higher IL-17 levels when compared to the healthy ...
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IL-17-differentiated macrophages secrete pro-inflammatory cytokines in response to oxidized low-density lipoprotein
... with IL-17. Macrophages differentiated with IL-17 formed few foam cells, with an average proportion of 20%, and expressed 3 times as much TLR2 and ...with IL-17 acquired ...
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Role of IL-17 in plaque psoriasis: therapeutic potential of ixekizumab
... neutralize IL-17A. This article reviews the role of IL-17 in the pathogenesis of psoria- sis, the biological and pharmacokinetics of ixekizumab and the safety profile and the clinical efficacy of ...
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