Anti-leishmanial
Anti-Leishmanial Activity of Pelargonium roseum Essential Oil on Growth of Leishmania infantum Promastigotes
... University, Science and Research branch, Tehran, Iran (IAUH). Essential oil of the plant was prepared by hydrodistillation from fresh leaves. Gas chromatography analysis was performed to reveal its chemical constituents. ...
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Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives
... for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC 50 values rang- ing from 0.7 ± 0.01 to 13.30 ± 0.50 µM respectively when compared with standard ...
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The Anti-leishmanial Efficacy of Artemisia dracunculus Ethanolic Extract in Vitro and Its Effects on IFN- γ and IL-4 Response
... the anti- leishmanial effects of a number of Artemisia species, almost all eleven species of Artemisia in Iran had effects against ...had anti-lishmanial effects (7). In the study on the ...
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IN VITRO ANTI-LEISHMANIAL ACTIVITY AGAINST CUTANEOUS LEISHMANIA PARASITES AND PRELIMINARY PHYTOCHEMICAL ANALYSIS OF FOUR YEMENI MEDICINAL PLANTS
... safe anti-leishmanial drug 8-11 ...cutaneous anti-leishmanial activity of Euphorbia cactus Ehrenb, Euphorbia ammak Forssk, Euphorbia inarticulate Schweinf, stems and leaves of Pergularia ...
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<p>Intracellular anti-leishmanial effect of Spergulin-A, a triterpenoid saponin of <em>Glinus oppositifolius</em></p>
... the anti-leishmanial activity of ...and anti-in fl ammatory (IL-10 and TGF- β ) were measured in control, infected, Spergulin-A treated M Ф ...and anti-inflammatory IL-10 and TGF-β with β- actin ...
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Anti-leishmanial Activity of Methanolic Extract of Nerium oleander L. against Leishmania major
... Results: All concentrations of the extract significantly reduced the viability of promastigotes when compared with the controls. Half-maximal inhibitory concentration was estimated to be 22.21 µg/ml after 24 hours. ...
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Evaluation of Anti-Leishmanial Efficacy by In Vivo Administration of Herbal Extract Artemisia Auchery on Leishmania Major in BALB/C Mice
... In this study, liver, spleen and lymph nodes were studied as target organs to detect amastigotes and to evaluate visceralisation of this cutaneous form of leishmania parasite. This extract had anti- ...
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Design, synthesis and biological evaluation of piperazinyl β carbolinederivatives as anti leishmanial agents
... leishmaniasis (PKDL) [2]. Among these, visceral Leishmaniasis is considered as severe form and is caused by Leishmania donovani and Leishmania infantum. Visceral leishmaniasis affects internal organs such as bone marrow, ...
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<p>Evaluation of the Anti-Leishmanial Effect of Recombinant <em>Clostridium</em> α-Toxin</p>
... In this way, another study was aimed to design a different method of drug delivery for increased transfer of the choice drug (meglumine antimoniate) within the host cells. Therefore, listeriolysin O (LLO), a bacterial ...
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Novel targeting using nanoparticles: an approach to the development of an effective anti-leishmanial drug-delivery system
... The purpose of the study presented here was to develop a nanoparticle system containing Cs, ChS, and AmpB, and to evaluate its anti-leishmanial activity against in vitro promastigote and in vivo amastigote ...
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Luteolin, an Abundant Dietary Component is a Potent Anti-leishmanial Agent that Acts by Inducing Topoisomerase II-mediated Kinetoplast DNA Cleavage Leading to Apoptosis
... their anti-leishmanial ef- fects primarily through topoisomerase inhibi- tion, like the known anti-leishmanial drug, pentamidine, and the known anticancer drugs, etoposide and ...
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Biological evaluation and structure activity relationship of 9 methyl 1 phenyl 9H pyrido[3,4 b]indole derivatives as anti leishmanial agents
... on anti-leishmanial activity as well as cytotoxicity of these ...substitution anti-promastigote activity altered ...on anti-leishmanial activity of these analogues, position of ...
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Anti-Leishmanial Activity of Flavanone Analogues Targeting Pteridine Reductase
... electron withdrawing group or without electronic effect on main nucleus. The presence of strong electron withdrawing group on the entire structure significantly reduced the leishmanicidal activity as observed in com- ...
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EXPLORING THE ANTI-LEISHMANIAL ACTIVITY OF OF PHOENIX DACTYLIFERA (DATE PALM)
... Leishmanial promastigotes were grown in NNN culture medium using normal saline. Parasites at log phase were centrifuged at 2000 rpm, washed three times with saline at same speed for 10 min. Parasites were diluted ...
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In vitro anti leishmanial activity of Onosma stenosiphon extract against
... Onosma is a genus of flowering plants in the family Boraginaceae that initiate in the Asia, Mediterranean regions and Europe. Some Onosma species are preloved as herbs, dyes and folk medicines (fig.1). Dried flowers of ...
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Anti-Leishmanial and Immunomodulatory Effects of Epigallo-catechin 3-O-Gallate on Leishmania tropica: Apoptosis and Gene Expression Profiling
... The anti- promastigote treatments were incubated at 24 °C±1 °C for 72 h, and the microtubes were washed three times with PBS and incubated in dark at ambient ...
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Leishmanial Excretory-Secretory proteins: A potent vaccine candidate
... Bihar, Assam, West Bengal, and eastern Uttar Pradesh the most affected regions by visceral leishmaniasis, where resistance and relapse against the present anti-leishmanial drugs are on lift up. The present ...
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“Hydrazones as Promising Lead with Diversity in Bioactivity-Therapeutic Potential in Present Scenario” BY Suman Bala, Goldie Uppal, Anu Kajal, Sunil Kamboj, Vaibhav Sharma, India. Digital copy link
... analgesic, anti-inflammatory, antioxidant, antiproliferative, antitubercular, antimalarial, anti-HIV, antiplatelet, anticonvulsant and anti-leishmanial ...
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Optimization of the Timing of Induction for the Assessment of Nitric Oxide Production in Leishmania major Infected Macro-phage Cells
... In Leishmania infections, the factors that in- duce Th1 or Th2 immune response are direct- ly linked to resistance and control or sensitivi- ty and exacerbation of the disease in BALB/c mice respectively. In addition to ...
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Antimicrobial activity of an antimicrobial peptide against amastigote forms of Leishmania major
... the anti-leishmanial activities of various concentrations of CM11 peptide (8, 16, 32 and 64 µM) were evaluated for 24, 48 and 72 hr by DAPI ...new anti-leishmanial ...
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