Anti-malarial
Novel pantothenate derivatives for anti malarial chemotherapy
... Vanin/pantetheinase activity assay with aminomethyl- coumarine (AMC) substrate and fluorescence readout was performed as described previously in Jansen et al. [13,21]. Human serum was used as a source of vanin enzymatic ...
8
Spectrophotometric detection of susceptibility to anti malarial drugs
... Since spectroscopic measurements have high sensitivity to the size and composition of particles and cells, the action of anti-malarial drugs on the structure and composition of the parasites and IRBCs led ...
9
Substandard anti malarial drugs in Burkina Faso
... Overall, 18/86 (21%) samples, which had failed the GPHF-Minilab disintegration and/or semi-quantitative thin-layer chromatography tests, were re-tested for confir- mation. Another 9/86 (10%) drug samples showed tailing ...
9
The past, present and future of anti malarial medicines
... present anti-malarial drugs highlights the need for continued research to stay one step ...of anti-malarial medicines developed over the years are reviewed, beginning with the discovery of ...
21
Epidemiological models for the spread of anti malarial resistance
... The approach offered here can provide insights into sever- al aspects of the epidemiology of anti-malarial resistance. It remains unclear why chloroquine resistance has emerged much later in sub-Saharan ...
11
Recent progress in the development of anti malarial quinolones
... the anti-malarial properties of quino- lones, compared to their anti-bacterial properties, are relatively ...of anti-malarial properties of quinolones, how- ever, indicates that these ...
10
MOLECULAR MODELLING, QSAR AND PHARMACOPHORE STUDIES ON ANTI VIRAL, ANTI MALARIAL AND ANTI INFLAMMATORY BIOACTIVE COMPOUNDS FROM MARINE SOURCES
... Structure based drug design provides a detailed knowledge of the binding sites of targets (proteins) associated with the corresponding disease. The activity or effectiveness of the compounds depends on the structural ...
8
Synergistic anti malarial action of cryptolepine and artemisinins
... novel anti-malarial ...and anti-malarial interaction (in vitro and in vivo) when CPE, the major alkaloid of the plant is combined with some artemisinin ...standard anti-malarial ...
12
Deployment and utilization of next generation sequencing of Plasmodium falciparum to guide anti malarial drug policy decisions in sub Saharan Africa: opportunities and challenges
... New methods, such as targeted NGS (TNGS) and asso- ciated bioinformatics tools have recently provided pos- sibilities for application to surveillance of anti-malarial resistance [73–76]. These methods are ...
10
Ultrasonographic assessment of splenic volume at presentation and after anti malarial therapy in children with malarial anaemia
... falciparum malaria in a hyperendemic area of coastal PNG is variable and not associated with the degree of anaemia at presentation. Simple clinical measures of splenic enlargement (uniaxial splenic length below the ...
9
Tafenoquine and NPC 1161B require CYP 2D metabolism for anti malarial activity: implications for the 8 aminoquinoline class of anti malarial compounds
... cluster and do not express a functional CYP 2D enzyme capable of metabolizing CYP 2D6 substrates [21]. The hu- manized/CYP 2D6 knock-in mice have the deletion of the mouse CYP 2D gene cluster, which is replaced with a ...
9
Does anti malarial drug knowledge predict anti malarial dispensing practice in drug outlets? A survey of medicine retailers in western Kenya
... first-line anti-malarial treatment while decreas- ing the use of SP and other anti-malarials for which there is known drug ...outdated anti-malarials even with knowledge of current recommended ...
9
In vitro and in vivo anti malarial activity of limonoids isolated from the residual seed biomass from Carapa guianensis (andiroba) oil production
... vivo anti-malarial activity in the Peters 4-day suppressive test against the Plasmodium berghei NK65 strain in BALB/c female mice, each inoculated with 1 × 10 5 parasitized red blood cells ...
8
Drug repositioning as a route to anti malarial drug discovery: preliminary investigation of the in vitro anti malarial efficacy of emetine dihydrochloride hydrate
... The objective of this study was the selective corrobor- ation of some of the candidates identified in the Lucumi study and the further definition/characterization of these leads to identify stand-alone ...
11
Novel propenones bearing napthyl moiety as potent anti malarial agents: Anti tubercular screening activity and their synthesis and characterization
... Species of mosquito spread different kinds of disease caused by bacteria, viruses or parasite globally .These mosquitoes actually don’t cause disease they just act as vector they inject the disease through their bites ...
6
The quality of anti malarial medicines in Embu County, Kenya
... Sampling of anti-malarials was performed by the study team during field visits. Sampling was performed accord- ing to the active pharmaceutical ingredient (API) pro- file. For purposes of this study, a sample was ...
5
Metal chloroquine derivatives as possible anti malarial drugs: evaluation of anti malarial activity and mode of action
... Background: Malaria still has significant impacts on the world; particularly in Africa, South America and Asia where spread over several millions of people and is one of the major causes of death. When chloroquine ...
8
Drug repositioning as a route to anti malarial drug discovery: preliminary investigation of the in vitro anti malarial efficacy of emetine dihydrochloride hydrate
... successful anti-malarials to date have indeed been plant derived molecules ...nanomolar anti- malarial efficacy makes it a useful reserve treatment option for cerebral malaria where in- hospital ...
24
Modulating effects of plasma containing anti malarial antibodies on in vitro anti malarial drug susceptibility in Plasmodium falciparum
... to anti-malarial antibodies, plasma obtained from patients with an acute falciparum malaria infection also contains other factors which inhibit parasite ...the anti-malarial drug sensitivity ...
8
The role of anti malarial drugs in eliminating malaria
... effective anti-malarial drugs either alone or in combination with other control meas- ures, particularly insecticide treated bed nets and indoor residual spraying, reduces malaria morbidity and mortal- ity ...
6