Anti-Malarial Drug
CPP ZFN: A potential DNA targeting anti malarial drug
... a drug from the combination of CPP and ZFN can effectively enter the intracellular parasite, introduce deleterious changes in its genome, and eliminate the parasite from infected ...ZFN-based anti- ...
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Does anti malarial drug knowledge predict anti malarial dispensing practice in drug outlets? A survey of medicine retailers in western Kenya
... first-line anti-malarial drug treatment for uncomplicated malaria, self-reported actions regarding diagnosis and dispensing practices, and responses to scenarios involving customer ...
9
Spread of anti malarial drug resistance: Mathematical model with implications for ACT drug policies
... of anti-malarial drug resistance [21-26], and increasing the recovery rate of an established infection ...type, drug resistance, and likelihood of patient adherence to ...
12
Modulating effects of plasma containing anti malarial antibodies on in vitro anti malarial drug susceptibility in Plasmodium falciparum
... incubated at room temperature for 30 minutes (pro- tected from light), and then washed twice with PBS. The slides were counterstained and mounted with 10 μg/ml ethidium bromide (Sigma, USA) in 50% gly- cerol (Sigma, ...
8
Measuring windows of selection for anti malarial drug treatments
... of anti-malarial drug resistance. Three processes drive drug resistance: the ability to survive treatment, the WoS and intra-host dynamics ...of anti-malarials can only be achieved ...
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Evaluation of bioluminescence based assays of anti malarial drug activity
... of drug treatment. Rate-of-kill is a critical determinant of anti-malarial drug action and ideally this should be as fast as possible ...cure drug, with the intention of rapidly ...
10
Tools for surveillance of anti malarial drug resistance: an assessment of the current landscape
... of anti-malarial drug resistance and react accordingly, surveillance systems able to detect and track in real-time its emergence and spread need to be strengthened or in some places ...of ...
16
Hyperparasitaemia and low dosing are an important source of anti malarial drug resistance
... Heritable anti-malarial drug resistance could arise at any nuclear ...to anti-malarial drugs when a newly acquired infection encounters residual anti-malarial drug ...
18
Malaria burden and anti malarial drug efficacy in Owando, northern Congo
... individual preventive measures [13]. Long-lasting insec- ticide-treated nets (ITN) to protect pregnant women and children under 5 years old and intermittent pre- ventive treatment during pregnancy (IPTp) with SP are the ...
10
Drug repositioning as a route to anti malarial drug discovery: preliminary investigation of the in vitro anti malarial efficacy of emetine dihydrochloride hydrate
... of drug candidates fail during development, this ap- proach which utilizes bioactive compounds with known safety profiles must necessarily be advantageous ...malaria, drug repositioning may not only deliver ...
11
Quantum dots: a new tool for anti malarial drug assays
... Background: Malaria infects over 300 million people every year and one of the major obstacles for the eradication of the disease is parasite ’ s resistance to current chemotherapy, thus new drugs are urgently needed. ...
5
Drug repositioning as a route to anti malarial drug discovery: preliminary investigation of the in vitro anti malarial efficacy of emetine dihydrochloride hydrate
... monitor drug susceptibility exploits the fact that the parasites reside in red cells, which are devoid of a ...of anti-malarial drug candidates selected from preliminary ...the drug ...
24
CRIMALDDI: platform technologies and novel anti malarial drug targets
... One approach is the mining of genomic databases to iden- tify novel targets (see below), followed by the screening of high diversity chemical libraries on such targets. Another strategy consists of first using such ...
11
Patterns of anti malarial drug treatment among pregnant women in Uganda
... of anti-malarial drugs [20,24-27] and often delays the diag- nosis of other febrile illnesses leading to poor clinical outcomes and heightened mortality ...most anti-malarials recommended for use in ...
8
Pharmacokinetic modelling of the anti malarial drug artesunate and its active metabolite dihydroartemisinin
... When processes involved in the system being modelled are not well understood, it can be informative to perform model selection based on comparing a relative goodness of fit statistic for a variety of structural models, ...
16
Optimizing the programmatic deployment of the anti malarials artemether lumefantrine and dihydroartemisinin piperaquine using pharmacological modelling
... predict drug effectiveness at the individual and population level and to investigate the effects of de- creased parasite drug susceptibility to treatment and poor patient adherence an already existing, ...
18
Has doxycycline, in combination with anti malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa?
... has anti-malarial properties and is already recommended as prophylaxis for travellers and for treatment of falciparum malaria in combination with other anti-malarial ...falciparum, ...
6
Exposure to anti malarial drugs and monitoring of adverse drug reactions using toll free mobile phone calls in private retail sector in Sagamu, Nigeria: implications for pharmacovigilance
... to anti-malarial drug, measured by the amount of drugs purchased within the ...A drug-data chart was designed to capture information on category of drugs ...of anti- malarial of ...
6
The role of anti malarial drugs in eliminating malaria
... six anti-malarial trials conducted in The Gambia and ...effective anti-malarial drug treatment increases gametocyte carriage both by reducing asexual parasite killing and by providing a ...
6
Awareness of malaria and treatment-seeking behaviour among persons with acute undifferentiated fever in the endemic regions of Myanmar
... Anti-malarial drug resistance is a major threat in this region with the emergence of artemisinin drug resist- ...of drug resistance requires improving the way drugs are used through ...
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