antibody dependent cellular cytotoxicity
Adipose cells promote resistance of breast cancer cells to trastuzumab mediated antibody dependent cellular cytotoxicity
... as antibody-dependent cellular cytotoxicity (ADCC), has been shown to be dependent on expression of Fc receptors (FcRs) by in- nate immune cells ...
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CD4- and Time-Dependent Susceptibility of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity
... through antibody-dependent cellular cytotoxicity (ADCC) represents a potentially useful immune response to integrate into vaccination or curative strategies against HIV-1 ...
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Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells
... through antibody-dependent cellular cytotoxicity ...elicited antibody-mediated NK cell activation but did not result in antibody-mediated ...CD4-induced antibody epitopes ...
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Incomplete Downregulation of CD4 Expression Affects HIV-1 Env Conformation and Antibody-Dependent Cellular Cytotoxicity Responses
... While ADCC responses against HIV-1 have been associated with protection against HIV-1 transmission and disease progression (23, 46–51), there are conflicting reports regarding the ability of nonneutralizing CD4i Abs to ...
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Antibody-Dependent Cellular Cytotoxicity Directed against Cells Expressing Human Immunodeficiency Virus Type 1 Envelope of Primary or Laboratory-Adapted Strains by Human and Chimpanzee Monoclonal Antibodies of Different Epitope Specificities
... TILLEY1* Received 9 June 1997/Accepted 7 October 1997 The characteristics of antibody-dependent cellular cytotoxicity ADCC directed by a panel of human and chimpanzee antienvelope anti-E[r] ...
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Antibody-Dependent Cellular Cytotoxicity Is Associated with Control of Pandemic H1N1 Influenza Virus Infection of Macaques
... virus-specific antibody-dependent cellular cytotoxicity (ADCC)-mediated NK cell activation dimin- ished in titer over time following sH1N1 infection, these cells expanded rapidly within 7 days ...
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Uninfected Bystander Cells Impact the Measurement of HIV Specific Antibody Dependent Cellular Cytotoxicity Responses
... ABSTRACT The conformation of the HIV-1 envelope glycoprotein (Env) substantially impacts antibody recognition and antibody-dependent cellular cytotoxicity (ADCC) responses. In the ...
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Differences in the Binding Affinity of an HIV 1 V2 Apex Specific Antibody for the SIVsmm/mac Envelope Glycoprotein Uncouple Antibody Dependent Cellular Cytotoxicity from Neutralization
... in HIV-1 Env modulate sensitivity to this antibody. Whereas a substitution in a con- served N-linked glycosylation site (N171Q) eliminates sensitivity to ADCC, a lysine-to- serine substitution in this region ...
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Antibody Dependent Cellular Cytotoxicity Competent Antibodies against HIV 1 Infected Cells in Plasma from HIV Infected Subjects
... A panel of BnAbs and NnAbs to various HIV Env epitopes was used to assess their binding and ADCC competence. Anti-Env Abs with specificity to the CD4bs (i.e., b12, VRC01, NIH45-46, and 3BNC117) and glycan-dependent ...
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Clinical development of targeted and immune based anti-cancer therapies
... ADCC: Antibody-dependent cellular cytotoxicity; AKT: Protein kinase B; APC: Antigen presenting cells; ATP: Adenosine 5 ′ triphosphate; BSC: Best supportive care; CRC: Colorectal cancer; ...
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Comparison of cytotoxic properties of neonatal and adult neutrophils and monocytes and enhancement by cytokines.
... Both adult and newborn PMNs lyse CRBCs and herpes simplex virus-infected CEM cells in antibody-dependent cellular cytotoxicity assays, and this lysis could be enhanced by the cytokines g[r] ...
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Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again
... recombinant antibody that can mediate antibody-dependent cellular cytotoxicity (ADCC) and complement-mediated cellular cytotoxicity, and may deplete tumor-infiltrating ...
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Vaccination of mice with a recombinant novel cathepsin B inhibits Trichinella spiralis development, reduces the fecundity and worm burden
... In the present study, the level of anti-TsCB IgE serum in vaccinated mice was also determined. The results showed that vaccination with rTsCB elicited specific IgE, which plays a major role in the rapid expulsion of ...
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A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies
... the antibody dependent cellular cytotoxicity (ADCC) efficacy of GBR 401 was assessed in a B cell depletion model consisting of SCID mice injected with healthy human donor PBMC, and a malignant ...
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Investigating remission and relapse in type 1 diabetes. Immune correlates of clinical outcome in beta-cell replacement therapies
... Significant variation for the HLA staining was noted when optimizing HLA specific staining in different organs. This was especially relevant since HLA expression was studied on transplanted pancreatic endocrine tissue ...
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The role of nonspecific cytotoxic cells and cytokine production in the pathogenesis of human intestinal diseases
... General Introduction 1.1 Characteristics of natural killer and killer cells 1 1.2 Killer cells and antibody-dependent cellular cytotoxicity 6 1.3 The origin and differentiation of natura[r] ...
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B cell targeted therapeutics in clinical development
... ADCC, antibody-dependent cellular cytotoxicity; AIHA, autoimmune hemolytic anemia; APRIL, a proliferation-inducing ligand; BAFF, B-cell activating factor; BCR, B-cell receptor; BILAG, British ...
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Molecular characterization of a 31 kDa protein from Trichinella spiralis and its induced immune protection in BALB/c mice
... Antibody-dependent cellular cytotoxicity (ADCC) test A test of the cytotoxic effect of anti-rTs31 antibodies on the NBL was performed [50, ...
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Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies
... NK cells are another important component of the im- mune system which have proven to be effective at kill- ing malignant cells [14–17]. In contrast to T cells, NK cells do not require antigen priming and are HLA ag- ...
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Monoclonal antibodies targeting cancer: 'magic bullets' or just the trigger?
... The first monoclonal antibodies (mAbs) approved for cancer therapy are now in Phase II and III trials, but the critical mechanism(s) determining efficacy and response in patients are still largely undefined. Both the ...
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