Antibody-dependent enhancement
Specific Ablation of Antiviral Gene Expression in Macrophages by Antibody-Dependent Enhancement of Ross River Virus Infection
... Ross River virus (RRV) is an indigenous Australian arthropod-borne alphavirus responsible for epidemic polyarthritis (EPA), myalgia, and lethargy in humans. Macrophages and monocytes have been associated with human RRV ...
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Enterovirus 71 Infection of Monocytes with Antibody-Dependent Enhancement
... Enterovirus (EV) is an RNA virus that has circulated with different serotypes and genotypes worldwide. Enterovirus 71 (EV71) is a major neurotropic virus that causes severe brain stem encephalitis (BE) in infants and ...
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Cell Type Specificity and Host Genetic Polymorphisms Influence Antibody-Dependent Enhancement of Dengue Virus Infection
... Antibody-dependent enhancement (ADE) is implicated in severe, usually secondary, dengue virus (DV) ...(without antibody) or ADE conditions (with ...at enhancement titers, but distinct ...
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The expression profile of human peripheral blood mononuclear cell miRNA is altered by antibody dependent enhancement of infection with dengue virus serotype 3
... Dengue virus (DENV) is a mosquito-borne virus that causes serious widespread public health issues in tropic and sub-tropical areas of the world. There are more than 100 countries where DENV is endemic, and the hardest ...
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A conceptual model for optimizing vaccine coverage to reduce vector-borne infections in the presence of antibody-dependent enhancement
... Our conceptual model formulation is guided by Zika outbreaks in dengue endemic areas. Dengue fever is caused by any of four closely related viruses or serotypes (DENV 1, DENV 2, DENV 3, DENV 4) and is transmitted between ...
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Antibody dependent enhancement infection of Enterovirus 71 in vitro and in vivo
... Antibody-dependent enhancement (ADE) of virus infection is a phenomenon in which preexisting sub- neutralizing antibodies enhance virus entry and replica- ...
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Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement.
... The S glycoprotein of feline infectious peritonitis virus (FIPV) has been shown to contain the antigenic sites responsible for eliciting both neutralization and antibody-dependent enhancement. To ...
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Role of Dendritic Cells in Antibody-Dependent Enhancement of Dengue Virus Infection
... itself. Antibody-dependent enhancement (ADE), a process best described in vitro, is epidemiologically linked to complicated DV infections, especially in South- east ...at enhancement titers, ...
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Identification of Aleutian Mink Disease Parvovirus Capsid Sequences Mediating Antibody-Dependent Enhancement of Infection, Virus Neutralization, and Immune Complex Formation
... antiviral antibody. Al- though antibody can neutralize ADV infectivity in Crandell feline kidney cells in vitro, virus is not cleared in vivo, and capsid-based vaccines have proven uniformly ...Antiviral ...
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Antibody dependent enhancement of frog virus 3 infection
... infectivity. Antibody dependent enhancement (ADE) occurs when viral antibodies enhance infectivity of a virus by promot- ing the attachment of viral particles to ...
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Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody dependent enhancement
... cross-reactive antibody populations of passively transferred RDERR vaccinated Swiss Webster mouse sera can reduce homologous ADE in ...neutralizing antibody titers were ...
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Medical Countermeasures Analysis of 2019-nCoV and Vaccine Risks for Antibody-Dependent Enhancement (ADE)
... Variation results identified multiple continuous linear segments of critical residues from which T cell epitopes can be selected in SARS-CoV-2 replicase enzymes and accessory proteins (Figure 2). Antibodies developed ...
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Antibody-dependent enhancement of respiratory syncytial virus infection by sera from young infants.
... activity (e.g., from older individuals convalescent from RSV infection in the present study), neutralization predominates at high concentrations in serum even in U937 cells.. The balance[r] ...
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Antibody-Dependent Enhancement of Hepatitis C Virus Infection
... The HMAbs used in this study were part of a group of antibodies for which discrete domains on HCVE2 have been established by competitive assay. CBH7 represents immuno- genic domain C, CBH5 is identified as being from the ...
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Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody-dependent enhancement of infection of feline macrophages.
... The aims of this work were to confirm that virus-specific feline antiserum can mediate ADE of FIPV infectivity in vitro and to determine whether FIPV-specific murine monoclonal Abs MAbs [r] ...
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Antibody-dependent enhancement of simian immunodeficiency virus (SIV) infection in vitro by plasma from SIV-infected rhesus macaques.
... The inability of anti-CR2 monoclonal antibody to block C'-ADE of SIV infection completely may have several explanations: i the OKB7 epitope is only partially conserved between human and [r] ...
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Two receptors are required for antibody-dependent enhancement of human immunodeficiency virus type 1 infection: CD4 and Fc gamma R.
... HIV-1 infection of U937 cells was significantly enhanced by IgG antibody to HIV-1 diluted at serum equivalents of 10-3 and 10-4 as compared with the control, which was infected with HIV-[r] ...
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Aleutian mink disease parvovirus infection of mink macrophages and human macrophage cell line U937: demonstration of antibody-dependent enhancement of infection.
... Since the effects of anti-ADV antibodies on ADV-Utah I/kit infection of U937 cells were almost the same as those on ADV-G infection of U937 cells results not shown, ADE might play a role[r] ...
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Monoclonal antibody analysis of neutralization and antibody-dependent enhancement of feline infectious peritonitis virus.
... rue 6695 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Fifty-four monoclonal antibodies MAbs to feline infectious peritonitis virus FIPV were characterized according t[r] ...
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Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and Pathogenesis
... The antibody-dependent enhancement (ADE) model postulates that some DENV-specific antibodies, either cross-reactive antibodies from a previous DENV infection or subneutralizing levels of ...
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