Antibody Dependent Enhancement (ADE)
Specific Ablation of Antiviral Gene Expression in Macrophages by Antibody-Dependent Enhancement of Ross River Virus Infection
... Ross River virus (RRV) is an indigenous Australian arthropod-borne alphavirus responsible for epidemic polyarthritis (EPA), myalgia, and lethargy in humans. Macrophages and monocytes have been associated with human RRV ...
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Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement.
... causing antibody-dependent enhancement ...neutralizing antibody from previous natural exposure to virus, passive transfer of antibody, or vaccination frequently develop disease far more ...
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Role of Dendritic Cells in Antibody-Dependent Enhancement of Dengue Virus Infection
... itself. Antibody-dependent enhancement (ADE), a process best described in vitro, is epidemiologically linked to complicated DV infections, especially in South- east ...at enhancement titers, ...
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Cell Type Specificity and Host Genetic Polymorphisms Influence Antibody-Dependent Enhancement of Dengue Virus Infection
... Antibody-dependent enhancement (ADE) is implicated in severe, usually secondary, dengue virus (DV) ...(without antibody) or ADE conditions (with ...at enhancement titers, but distinct ...
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Antibody dependent enhancement infection of Enterovirus 71 in vitro and in vivo
... Antibody-dependent enhancement (ADE) of virus infection is a phenomenon in which preexisting sub- neutralizing antibodies enhance virus entry and replica- ...
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The expression profile of human peripheral blood mononuclear cell miRNA is altered by antibody dependent enhancement of infection with dengue virus serotype 3
... Dengue virus (DENV) is a mosquito-borne virus that causes serious widespread public health issues in tropic and sub-tropical areas of the world. There are more than 100 countries where DENV is endemic, and the hardest ...
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A conceptual model for optimizing vaccine coverage to reduce vector-borne infections in the presence of antibody-dependent enhancement
... Our conceptual model formulation is guided by Zika outbreaks in dengue endemic areas. Dengue fever is caused by any of four closely related viruses or serotypes (DENV 1, DENV 2, DENV 3, DENV 4) and is transmitted between ...
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Enterovirus 71 Infection of Monocytes with Antibody-Dependent Enhancement
... Enterovirus (EV) is an RNA virus that has circulated with different serotypes and genotypes worldwide. Enterovirus 71 (EV71) is a major neurotropic virus that causes severe brain stem encephalitis (BE) in infants and ...
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Antibody dependent enhancement of frog virus 3 infection
... infectivity. Antibody dependent enhancement (ADE) occurs when viral antibodies enhance infectivity of a virus by promot- ing the attachment of viral particles to ...
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Identification of Aleutian Mink Disease Parvovirus Capsid Sequences Mediating Antibody-Dependent Enhancement of Infection, Virus Neutralization, and Immune Complex Formation
... antiviral antibody in this syndrome (50). Furthermore, antiviral antibody enables ADV to infect cells such as macrophages or the monocytic cell line, K562, via an Fc-receptor-dependent mechanism ...
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Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody dependent enhancement
... Vaccinology has returned many successful endeavors in- cluding vaccines against smallpox, yellow fever, and childhood diseases such as pertussis and measles. Clas- sical methods of vaccine development have been vital in ...
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Antibody-Dependent Enhancement of Hepatitis C Virus Infection
... The HMAbs used in this study were part of a group of antibodies for which discrete domains on HCVE2 have been established by competitive assay. CBH7 represents immuno- genic domain C, CBH5 is identified as being from the ...
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Antibody-dependent enhancement of simian immunodeficiency virus (SIV) infection in vitro by plasma from SIV-infected rhesus macaques.
... The inability of anti-CR2 monoclonal antibody to block C'-ADE of SIV infection completely may have several explanations: i the OKB7 epitope is only partially conserved between human and [r] ...
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Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody-dependent enhancement of infection of feline macrophages.
... The aims of this work were to confirm that virus-specific feline antiserum can mediate ADE of FIPV infectivity in vitro and to determine whether FIPV-specific murine monoclonal Abs MAbs [r] ...
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Aleutian mink disease parvovirus infection of mink macrophages and human macrophage cell line U937: demonstration of antibody-dependent enhancement of infection.
... Since the effects of anti-ADV antibodies on ADV-Utah I/kit infection of U937 cells were almost the same as those on ADV-G infection of U937 cells results not shown, ADE might play a role[r] ...
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Increased adhesion as a mechanism of antibody-dependent and antibody-independent complement-mediated enhancement of human immunodeficiency virus infection.
... Complement-mediated antibody-dependent enhancement (C’ADE) has been found in vitro both in sera from three of four volunteers vaccinated with recombinant vaccinia virus ex- pressing human ...
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Two receptors are required for antibody-dependent enhancement of human immunodeficiency virus type 1 infection: CD4 and Fc gamma R.
... HIV-1 infection of U937 cells was significantly enhanced by IgG antibody to HIV-1 diluted at serum equivalents of 10-3 and 10-4 as compared with the control, which was infected with HIV-[r] ...
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Monoclonal antibody analysis of neutralization and antibody-dependent enhancement of feline infectious peritonitis virus.
... rue 6695 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Fifty-four monoclonal antibodies MAbs to feline infectious peritonitis virus FIPV were characterized according t[r] ...
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Pre- and postexposure protection by passive immunoglobulin but no enhancement of infection with a flavivirus in a mouse model.
... for antibody-dependent enhancement (ADE) as a pathogenic factor in vivo has been provided for dengue virus (10) by studies of disease in humans as well as by animal studies, but the role of ADE in ...
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Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and Pathogenesis
... The antibody-dependent enhancement (ADE) model postulates that some DENV-specific antibodies, either cross-reactive antibodies from a previous DENV infection or subneutralizing levels of ...
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