Antibody secreting cells
Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity
... Based on the gene expression data, CREB3L2 is predicted to increase as B-cells transition to antibody secreting cells (ASCs), however generation of the active transcription factor depends on ...
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Expansion of antibody secreting cells and modulation of neutralizing antibody activity in HIV infected individuals undergoing structured treatment interruptions
... In an elegant report studying the expansion of Influenza-virus specific ASC and their neutralizing Ab production, Wilson and colleagues used Flu vaccination to re-expose and restimulate the Flu-specific B cell memory in ...
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Alphavirus-Induced Encephalomyelitis: Antibody-Secreting Cells and Viral Clearance from the Nervous System
... plasmablasts secreting IgM, followed by germinal center production of IgG-secreting and memory B ...inflammatory cells to enter the brain were CD8 ⴙ T cells, followed by CD4 ⴙ T cells ...
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Enumeration of Gut-Homing β7-Positive, Pathogen-Specific Antibody-Secreting Cells in Whole Blood from Enterotoxigenic Escherichia coli- and Vibrio cholerae-Infected Patients, Determined Using an Enzyme-Linked Immunosorbent Spot Assay Technique
... 7-positive cells from a small volume of blood would allow measurement of the antigen- specific immune responses in patients with cholera and ETEC ...7-expressing cells from blood on days 2, 7, and 30 and ...
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Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells
... into antibody-secreting cells (ASCs) and thus may be amenable to differentiation ...differentiated cells. Our results show that differentiated CLL B-cells are able to display the ...
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Spec seq unveils transcriptional subpopulations of antibody secreting cells following influenza vaccination
... IgAVN cells are hypothesized to be steady-state sentinel cells recirculat- ing from mucosal sites, it is plausible that proliferation is neces- sary to maintain peripheral blood population ...full-length ...
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MyD88 Plays an Essential Role in Inducing B Cells Capable of Differentiating into Antibody-Secreting Cells after Vaccination
... marrow cells were analyzed by fluorescence- activated cell sorting (FACS) to determine germinal and plasma cells after immunization of MyD88-deficient or wild-type ...marrow cells were obtained by ...
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Age-related changes in the transcriptome of antibody-secreting cells
... aging, cells accumulate DNA mutations, which may lead to structural changes of DNA ...prevents cells from progressing through the cell cycle, increases DNA repair mechanisms or drives cells to ...
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Early emergence of CD19-negative human antibody secreting cells at the plasmablast to plasma cell transition
... human cells, we turned to in vitro models of long-lived PC dif- ...B cells to the PB state follows a well-defined pattern leading to the generation of CD19 pos PBs from CD19 pos activated B cells ...
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Influenza virus-specific antibody-secreting cells in the murine lung during primary influenza virus infection.
... The proposition that these cells may arise from influenza virus-specific B-cell precursors in the lungs is directly supported by two findings in this study: i the generation of cells sec[r] ...
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Astrocyte-Derived CXCL10 Drives Accumulation of Antibody-Secreting Cells in the Central Nervous System during Viral Encephalomyelitis
... Impaired Ab production within the CNS of CXCL10 ⴚ/ⴚ mice. ASC recruitment into the CNS is CXCR3 dependent in C57BL/6 mice following infection with a gliatropic strain of coronavirus, as well as with a dual hepato- and ...
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Induction of B cell responses in the stomach of Helicobacter pylori infected subjects after oral cholera vaccination
... inducing antibody re- sponses locally in the human stomach as a prerequisite for the development of a vaccine against Helicobacter pylori ...vaccine-specific antibody-secreting cells (ASC) ...
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A Combination Vaccine Consisting of Three Live Attenuated Enterotoxigenic Escherichia coli Strains Expressing a Range of Colonization Factors and Heat-Labile Toxin Subunit B Is Well Tolerated and Immunogenic in a Placebo-Controlled Double-Blind Phase I Trial in Healthy Adults
... nitude of anti-LTB and the frequency of anti-CF responses being detected. The predominant systemic immune response was against LTB. A clear dose-response was seen in serum anti-LTB responses, with 10/12 recipients of the ...
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Mitochondria rich, proton secreting epithelial cells
... principal cells are present in medullary collecting ducts, but that in the adult mouse, intercalated cells are virtually absent from all regions of the medulla (Breton et ...intercalated cells are ...
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Polychromatic flow cytometry in evaluating rheumatic disease patients
... Figure 2 Unsupervised clustering analysis of B-cell profiles segregates lupus patients into distinct groups. Flow cytometry data from 25 healthy controls (HC) and 137 systemic lupus erythematosus (SLE) patients were ...
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IL 5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
... anti-OxLDL antibody, was a natural antibody secreted by innate B-1 cells in a T cell–indepen- dent (TI) manner and possessed the germline-encoded T15 clono- type ...apoptotic cells, but does ...
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Enzyme-Linked Immunospot Assay Detection of Mumps-Specific Antibody-Secreting B Cells as an Alternative Method of Laboratory Diagnosis
... B cells and ASCs than those specific for measles, and there were more measles-specific cells observed than for ...B cells that are available to respond in a given ...these cells were present, ...
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Simple diagnosis of Encephalitozoon sp microsporidial infections by using a panspecific antiexospore monoclonal antibody
... by antibody 3B6 in ...monoclonal antibody 3B6 appear to be highly ...monoclonal antibody 3B6 recognized similar antigens among Encephalitozoon ...monoclonal antibody 3B6 reduced infectivity of ...
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Delayed in Vitro Immunoglobulin Production by Cord Lymphocytes
... In the present study on Ig production by cord lymphocytes in vitro, we therefore measured cells secreting the major three classes of Ig by Ig-secreting plaque- forming cell (Ig-PFC) assa[r] ...
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Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN gamma secreting TH1 cells in humans
... (TH2)-type cells in the anti-CD4 treated group was observed, numbers of IFN- g –producing T helper 1 (TH1)-type cells remained stable, resulting in a significant increase in the TH1/TH2 ...the cells ...
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