Anticancer Drug Delivery
PROTEINS AND PEPTIDES AS TARGETING CARRIERS IN ANTICANCER DRUG DELIVERY: A REVIEW
... of drug- and radiation-resistant tumor cells, tumor heterogeneity and the presence of metastatic ...‘targeted’ delivery to tumor ...site-selective delivery has been achieved only with “targeting ...
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Transcriptome-wide elucidation of liposomal formulations for anticancer drug delivery
... Abstract: Although widely used in chemotherapy, free doxorubicin (Dox) might enhance cell malignancy undesirably. Liposomal Dox (Doxlipo) has been clinically approved for the treatment of breast cancer due to reduced ...
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Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery
... for delivery of DCT via intravenous ...sustained drug release pattern was ...vivo drug clearance, elevated systemic exposure, and prolonged circulation of the drug were verified in a ...
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A cell cycle automaton model for probing circadian patterns of anticancer drug delivery
... Besides circadian cancer chronotherapy, another line of research resorting to periodic schedules of anticancer drug delivery has been proposed [32–35]. It is based on a resonance phenomenon between ...
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Silk nanoparticles : proof of lysosomotropic anticancer drug delivery at single cell resolution
... model drug for loading both native and PEGylated silk nanoparticles because (i) it is a clinically relevant anticancer drug, (ii) its site of action is the nucleus, making it ideally suited for ...
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Poly(Malic Acid) as a Carrier For Anticancer Drug Delivery Systems: A Mini Review
... polymer drug carriers by adjusting monomer/initiator ratio in the polymerization reaction ...antitumor drug, 10-hydroxycamptothecin (HCPT), was attached to the PMLA (Mw 13 kDa) backbone through a glycine ...
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<p>Folate and Pegylated Aliphatic Polyester Nanoparticles for Targeted Anticancer Drug Delivery</p>
... encapsulated drug or 250 nM free Paclitaxel for ~24 h (Supplementary Videos S1 – 2, ...Paclitaxel delivery, that the released drug remains active and that it affects the same cellular targets with ...
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Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery
... B-sensitive drug release properties, whereas the drug release kinetics of DendDP were not significantly ...improved anticancer activity when compared with doxorubicin or DendDP in an vivo mouse CT26 ...
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5 Fluorouracil encapsulated silver nanoparticle for effective anticancer drug delivery
... Fluorouracil (5-FU)by encapsulated FU shows poor solubility and low absorption rate therefore its silver nanoparticles was formed to increase solubility, absorption as well as affectivity against tumor. Various ...
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Magnetic properties of polyvinyl alcohol and doxorubicine loaded iron oxide nanoparticles for anticancer drug delivery applications
... target drug delivery via IONPs guided by external magnetic field has been optimized depending on the PVA concentration and magnetic studies suggest that the PVA concentration of 3 ...the drug ...
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Preparation and characterization of novel chitosan-protamine nanoparticles for nucleus-targeted anticancer drug delivery
... Based on the construction of carriers, the interactions between the carriers and targeted cells and their intracellular delivery process were further studied by using confocal laser scanning microscopy (FluoView ...
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Design and performance investigation of electrospun PVA nanofibers containing core-shell nanostructures for anticancer drug delivery
... targeted drug delivery of an anticancer drug of ...DAN drug were prepared by electrospining ...the drug at pH= 6 was higher than the release value at pH = ...targeted ...
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Gold Nanorods Conjugated with Doxorubicin and cRGD for Combined Anticancer Drug Delivery and PET Imaging
... including drug/gene delivery and photothermal therapy, as well as computed tomog- raphy (CT) and/or optical imaging [21, 30-32, ...model anticancer drug, was conjugated onto the GNR via a ...
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Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery
... In the present investigation, polyoxyethylene sorbitol oleate (PSO), based on polysorbate 80 containing a homo- genous sorbitol matrix, was developed for safer and more effective delivery of docetaxel, an ...
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ENCAPSULATION OF CURCUMIN IN SILVER NANOPARTICLE FOR ENHANCEMENT OF ANTICANCER DRUG DELIVERY
... The cells were treated with Cur-AgNPs in various concentrations (10, 20, 40, and 80 lg/mL) for 24 h. The amount of formulation needed to prepare molar equivalents of curcumin was calculated, based on the drug ...
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ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging
... different samples, including the saline as a negative control, DOX, DOX/PFP NPs and DOX/PFFP NPs. The growth of the tumor was significantly inhibited after the treatment with different DOX formulations (Figure 7A and ...
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PEGylated silk nanoparticles for anticancer drug delivery
... uses drug combinations to maximise clinical outcomes. Many anticancer drugs are small molecular weight compounds, where pharmacokinetics, tissue distribution, intracellular drug concentrations and ...
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Supporting Information. Self-Folded Redox/Acid Dual-Responsive Nanocarriers for. Anticancer Drug Delivery
... The homogenous RAD-NCs solution was dialyzed against DD water for 48 hours at room temperature in order to completely get rid of organic solvent DMSO.. The DD water was f[r] ...
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TARGETED NANOTECHNOLOGY FOR ANTICANCER DRUG DELIVERY: CURRENT ISSUE AND CHALLENGE
... The main aim of nonmaterials is optimization on site of action at tumors cells as well least toxicity by its formulation. Only to progress the biodistribution of neoplasia drugs, nanoparticles are designed for optimal ...
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Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles
... Although the Dox dose of 10 mg/kg was not sufficient to induce cures in any of the mice, it halted further tumor growth. On the other hand, the dose was linked to a signifi- cant toxicity in all the mice in this control ...
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