Antifungal Resistance
Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of Candida auris
... increased antifungal resistance in ...to antifungal resistance and environmental survival remain limited, but large aggregates of cells have been recovered from harvested tissue of a murine ...
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Distribution of secreted aspartyl protease (SAP) virulence genes and antifungal resistance genes at vulvovaginal candidiasis isolates
... and antifungal resistance features of Candida albicans considering a growing health problem ...azole resistance genes at 100 clinical isolates of Candida we used a model of infection of human vaginal ...
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Antifungal resistance: current trends and future strategies to combat
... azole resistance in ...frank resistance to many avail- able antifungal ...overcoming antifungal resistance and avoiding adverse effects and drug interactions associated with currently ...
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Rapid Detection of Triazole Antifungal Resistance in Aspergillus fumigatus
... Numerous advances in transplant medicine over the past decade have enabled patients to live longer with reduced mor- tality. However, infectious complications, such as invasive pul- monary aspergillosis (IA) continue to ...
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UPC2 Is Universally Essential for Azole Antifungal Resistance in Candida albicans
... drug resistance. Since UPC2 disruption in strains containing one resistance mechanism resulted in enhanced fluconazole activity, we wanted to examine further the extent to which disruption of UPC2 ...
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ANTIFUNGAL RESISTANCE OF FEW ASPERGILLUS SPECIES
... of resistance to antimicrobial agents that are used to control pathogens in medicine and agriculture is a well- documented ...drug resistance is more likely to proceed by the sequential accumulation of ...
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Epidemiology and antifungal resistance in invasive candidiasis
... the increase in incidence of Candida infections barely preceded the introduction of fluconazole in 1990. this azole agent combined good activity against Can- dida albicans with reduced toxicity as compared to i.e. ...
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An alarming rise of non albicans Candida species and uncommon yeasts in the clinical samples; a combination of various molecular techniques for identification of etiologic agents
... of antifungal agents ...raising resistance to antifungal agents among NAC species, imposes serious medical and economic problems to the society [7, ...their antifungal resistance by ...
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An insight into new strategies to combat antifungal drug resistance
... to antifungal resistance to a large extent. In addition, antifungal exposure under the circum- stances of prophylactic use and repetitious or long-term treatment is closely correlated with the ...
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Antagonism between Two Mechanisms of Antifungal Drug Resistance
... of resistance to FLC, increased efflux and altered sterol metabolism, has a clear implication for the evolution of drug resistance: multiple drug resistance mechanisms acting together do not always ...
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ABC and MFS Transporters: A reason for Antifungal drug resistance
... Growing resistance of the fungi against currently used antifungals is a matter of big concern for the scienti ic ...developing resistance against the antifungals is higher than the rates at which the new ...
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MOLECULAR CHARACTERIZATION OF AZOLE RESISTANCE MECHANISMS IN CANDIDA ALBICANS CLINICAL ISOLATES FROM HIV INFECTED PATIENTS IN INDIA
... in antifungal resistance because of their morbidity and mortality allied with infections in immunocompromised ...of resistance exist, with the most significant being those due to efflux ...of ...
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Antifungal Resistant in Non-Albicans Candida Species are Emerging as a Threat to Antenatal Women with Vulvovaginal Candidiasis
... the antifungal susceptibility pattern is important to know the resistant pattern of Candida ...the antifungal resistance pattern in Candida species isolated from the vaginal discharge of antenatal ...
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EVALUATİON OF ANTİ-BİOFİLM AND ANTİFUNGAL ACTİVİTİES OF MENTHA LONGİFOLİA ESSENTİAL OİL AGAİNST CLİNİCAL ISOLATES OF CANDİDA ALBİCANS
... the antifungal resistance of Candida yeasts. In addition, resistance mechanisms developed by Candida yeasts against antifungal agents cause significant challenges in combating biofilm- ...
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Antifungal Prophylaxis to Prevent Neonatal Candidiasis: A Survey of Perinatal Physician Practices
... excluded. Antifungal prophylaxis use was reported by 73 (34%) ...use antifungal prophylaxis compared with respondents who used fluconazole prophy- laxis were significantly more likely to have concerns about ...
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Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients
... There are multiple mechanisms for azole resistance. The first is based on the changes in the molecular configuration of the target enzyme 14α-demethylase (Erg11p) due to mutations in the encoding gene ERG11. It ...
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Molecular and Phenotypic Characterization of Genotypic Candida albicans Subgroups and Comparison withCandida dubliniensis and Candida stellatoidea
... the antifungal susceptibility testing for flucon- azole showed that ...the antifungal susceptibilities of this spe- cies (8, 13, ...fluconazole resistance at high frequency in vitro in ...
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Conserved Role for Biofilm Matrix Polysaccharides in Candida auris Drug Resistance
... of antifungal (fluconazole) susceptibility using an XTT endpoint ...intrinsic resistance mechanisms for individual strains, as the planktonic MICs varied ...the resistance observed in the present ...
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... many antifungal drugs are currently in clinical practice, further novel antifungal drugs and new drug targets are in need due to the fear of antifungal drug resistance and re-emergence of ...
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Mode of Selection and Experimental Evolution of Antifungal Drug Resistance in Saccharomyces cerevisiae
... of resistance was reproducible on agar medium with 128 g/ml FLC (MIC 64 g/ml) than the other (MIC 32 g/ml) and (Figure 2); the progenitor produced small colonies that that both mutant genes together confer an ...
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