Antigen-Induced Arthritis
Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen Induced Arthritis
... of Antigen-Induced Arthritis (A IA) Mice were immunized subcutaneously with 100 µl of an emulsion of 1 mg/ml·mBSA in Phosphate Buffered Sa- line (PBS) mixed with an equal volume of complete Freund’s ...
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Granulocyte macrophage colony stimulating factor receptor α expression and its targeting in antigen induced arthritis and inflammation
... rheumatoid arthritis (RA) with clinical results equivalent to those found with neutralization of the current therapeutic targets, TNF and ...in antigen-driven arthritis and inflammation models and ...
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Interferon alpha inhibits antigen specific production of proinflammatory cytokines and enhances antigen specific transforming growth factor beta production in antigen induced arthritis
... Antigen-induced arthritis (AIA) is an experimental model of RA that involves generation of antibodies and T cells with the capacity to transfer the disease ...is induced by intraarticular ...
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Efficacy of an immunotoxin to folate receptor beta in the intra articular treatment of antigen induced arthritis
... AIA: antigen-induced arthritis; BSA: bovine serum albumin; FCS: fetal calf serum; FR: folate receptor; Fv: fragment of Ig consisting of heavy: light chain variable domains; H & E: haematoxylin ...
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Syndecan 3 is selectively pro inflammatory in the joint and contributes to antigen induced arthritis in mice
... A pro-inflammatory function of sdc-3 was also appar- ent in a murine model of RA. Induction of AIA in the knee joint resulted in reduced joint swelling in sdc-3 knockout mice suggesting that sdc-3 contributes to the ...
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Exacerbation of antigen induced arthritis in urokinase deficient mice
... rheumatoid arthritis, synovial expression of urokinase (uPA) activity is greatly increased (Busso, ...murine antigen-induced ...during antigen-induced ...
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Therapeutic efficacy of intra articular adrenomedullin injection in antigen induced arthritis in rabbits
... with antigen- induced arthritis, an experimental model of rheumatoid ...of arthritis in both knee joints by ovalbumin injection into the joint spaces of pre-immunized rabbits, increasing daily ...
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Interleukin 6 dependent influence of nociceptive sensory neurons on antigen induced arthritis
... Because CGRP is rapidly increased in the joint during AIA development, we believe that the activation of neu- rons by IL-6 and the CGRP release are linked. Several findings support this view. First, in isolated DRG neu- ...
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Acute murine antigen induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling
... Serum levels of tumour necrosis factor α (TNF-α), interferon-γ (IFN-γ), murine interleukin-1α (IL-1α), IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12(p40), IL-12 (p70), IL-13, IL-15, IL-17A, IL-18, monocyte ...
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Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen induced arthritis
... The biological activity of the proteinases can be regulated transcriptionally and post-transcriptionally by different TIMPs and by activation steps by the proteolytic cleavage of latent forms. Van der Laan and colleagues ...
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Loss of phosphoinositide 3 kinase γ decreases migration and activation of phagocytes but not T cell activation in antigen induced arthritis
... in arthritis [13,21] but may be explained by different requirements for T cells among the three ...[21] induced arthritis by serum transfer from K/BxN mice to PI3Kγ-/- on a C57BL/6 background, a ...
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Attenuation of murine antigen induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription 1 (STAT 1)
... in arthritis, and this role is supported by elevated expression of the STAT-1 pro-apoptotic target gene caspase-1 in RA syn- ovium ...zymosan-induced arthritis has been observed [40] as well as ...
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Induction of chronic destructive arthritis in SCID mice by arthritogenic fibroblast like synoviocytes derived from mice with antigen induced arthritis
... Our FLS cultures still contained approximately 20% CD11b + macrophage-like cells after the third passage (data not shown). It is possible that these activated macro- phages and not the FLSs contained in these ...
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Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models
... In DK226, MTX and HA are linked with a peptide linker (Fig. 1), which is susceptible to cleavage by lyso- somal enzymes including cathepsins [38]. DK226 showed anti-proliferative effects on HFLS and SW982 cells, and ...
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S100A8 and S100A9 in experimental osteoarthritis
... rheumatoid arthritis (RA), cartilage breakdown in osteoarthritis (OA) is dri- ven primarily by the ...of antigen-induced arthritis (AIA); the effect of IL-1 a on S100a8 and S100a9 expression ...
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NF κB–inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis
... inflammatory arthritis using Nik–/– mice. The serum transfer arthritis model is initiated by preformed antibodies and required only intact neutrophil and complement systems in ...to ...
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Interleukin 10 regulates the inflammasome driven augmentation of inflammatory arthritis and joint destruction
... Figure 2 Bone erosions are augmented in the IL-10KO joints following antigen-induced arthritis (AIA). (A) Mankin ’ s score (indicating severity of cartilage damage) (left) and percentage of cartilage ...
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Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
... Rheumatoid arthritis (RA) is a common autoimmune disease of unknown etiology, characterized by chronic syn- ovial inflammation that leads to progressive destruction of cartilage and bone ...in ...
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Expression and function of junctional adhesion molecule C in human and experimental arthritis
... murine antigen-induced arthritis To investigate a potential role for JAM-C in arthritis, we tested the effect of the monoclonal anti-JAM-C antibody H36 [17] on the course of ...of ...
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Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist
... bFGF-augmented antigen-induced arthritis (AIA) was associated with a quantitative increase in vascular apop- tosis leading to the inhibition of synovial angiogenesis, as well as a reduction in joint ...
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