Antigenic peptide
Control of spontaneous ovarian tumors by CD8+ T cells through NKG2D-targeted delivery of antigenic peptide
... ovalbumin antigenic peptide to NKG2D ligand-expressing ovarian tumor cells to facilitate MHC class I presentation of the antigenic ...CTL peptide delivered by NKG2D-Fc-RO to tumor cells ...
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An H5N1 M2e based multiple antigenic peptide vaccine confers heterosubtypic protection from lethal infection with pandemic 2009 H1N1 virus
... multiple antigenic peptide (MAP) vaccine based on the extracellular domain of M2 protein (M2e) from H5N1 virus (H5N1-M2e-MAP) induced strong immune responses and cross-protection against different clades of ...
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Highly Sensitive Assay for Human Herpesvirus 8 Antibodies That Uses a Multiple Antigenic Peptide Derived from Open Reading Frame K8 1
... linear peptides without the need for conjugation to a carrier protein. This study shows that a MAP is also more strongly immunoreactive than the corresponding linear peptide, possi- bly due to enhanced binding to ...
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Organ specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide
... single peptide (Ea52-68) spontaneously develops peripheral nervous system–specific autoimmune disease with many of the histopathological features found in experimental allergic ...
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New Multiple Antigenic Peptide Based Enzyme Immunoassay for Detection of Simian Immunodeficiency Virus Infection in Nonhuman Primates and Humans
... To determine whether antibodies to HIV cross-react with SIV MAPs, 120 serum samples from infections with HIV-1 group M subtypes, 4 samples from infections with HIV-1 group O, 41 samples from infections with HIV-2, and 5 ...
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An M2e based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses
... multiple antigenic variants in multiple regions determine that development of H5N1 vaccine with cross-protection against divergent H5N1 viruses would be ...
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The specific T-cell response to antigenic peptides is influenced by bystander peptides
... foreign peptide-MHC combinations in the presence of self peptide-MHC combinations for which their receptors have some ...altered peptide ligand had an augmenting effect on the CD4 + T cell response ...
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Cathepsin S activity regulates antigen presentation and immunity
... of antigenic peptide to associate with class II mole- cules, and is not a consequence of a defect in antigen process- ...OVA peptide in A20 cells ...processing, peptide loading, and antigen ...
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PubMedCentral-PMC5708121.pdf
... SIINFEKL peptide via reduction sensitive, heterobifunctional linkers SPDP or NHS-PEG(2k)OPSS in a two step-process (Figure ...of antigenic peptide and CpG, we aimed to keep the overall charge of NPs ...
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Perforin independent β cell destruction by diabetogenic CD8+ T lymphocytes in transgenic nonobese diabetic mice
... mediated cytotoxicity, depending on the structure of the triggering antigenic peptide/MHC complex (43). In this regard, it is worth noting that 8.3-CTLs could not lyse NOD β cells from NOD.lpr/lpr mice ...
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Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model
... Core Peptide (LCP) incorporates a lipoamino acid-based non-microbial lipidic adjuvant with a poly- lysine multiple antigenic peptide (MAP) system [24] which allow the conjugation of multiple copies ...
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Induction of CD4+ T cell–dependent antitumor immunity by TAT mediated tumor antigen delivery into dendritic cells
... TAT peptide derived from the HIV TAT protein has the ability to transduce peptides or proteins into various ...an antigenic peptide derived from the human TRP2 protein generated partial protective ...
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Design, automated synthesis and immunological evaluation of NOD2-ligand-antigen conjugates
... the antigenic peptide is ...controls, peptide 29 and conjugate 30, showed no activity indicating that the activi- ties of 4 and 5 are a consequence of the presence of the MDP in these ...the ...
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A Putative Rhamnogalacturonase Required for Sexual Development of Neurospora crassa
... Western blot analysis Western blotting was per- formed to characterize the ASD-1 polyclonal antibodies (raised to a potentially antigenic peptide of the ASD-1 protein) and [r] ...
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Therapeutic applications of the 'NPGP' family of viral 2As
... Oligopeptide ‘2A’ and ‘2A-like’ sequences (‘2As’; 18-25aa) are found in a range of RNA virus genomes controlling protein biogenesis through ‘recoding’ of the host-cell translational apparatus. Insertion of multiple 2As ...
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Quantifying Antigenic Relationships among the Lyssaviruses
... field, N. Johnson, S. M. Brookes, G. Parsons, K. White, P. G. McIntyre, and D. Nathwani. 2003. Case report: isolation of a European bat lyssavirus type 2a from a fatal human case of rabies encephalitis. J. Med. Virol. ...
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Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
... Naturally acquired clinical immunity to Plasmodium falciparum is partly mediated by antibod- ies directed at parasite-derived antigens expressed on the surface of red blood cells which mediate disease and are extremely ...
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Mechanisms of Surface Antigenic Variation in the Human Pathogenic Fungus Pneumocystis jirovecii
... Surface antigenic variation has been previously studied on a limited set of genes in Pneumocystis carinii infecting specifically rats. The molecular mechanism was then assumed to be also active in P. jirovecii, as ...
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Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant Specific Immunity
... ABSTRACT Genomic analysis reveals extensive sequence variation and hot spots of re- combination in surface proteins of Streptococcus pneumoniae. While this phenomenon is commonly attributed to diversifying selection by ...
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Vol 2, No 7 (2011)
... called antigenic diversity. Thus, due to the ongoing antigenic variation more and more mutant specific immune responses become ...in antigenic diversity of HIV. The antigenic diversity ...
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