Antigenic variation
Selective Forces That Shape the VLS Antigenic Variation System in Borrelia Burgdorferi
... vls antigenic variation system in the Lyme disease bacteria Borrelia burgdorferi (Bb) continuously generates diversity at a site coding for an immunodominant surface antigen, VlsE, facilitating evasion from ...
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Hyper-antigenic variation occurs with human rhinovirus type 17.
... low-level antigenic variation ...the variation seen for RV-17 is unique among ...important antigenic sites are localized to VP1 ...possible antigenic sites) need to be iden- ...possible ...
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Antigenic analysis of classical swine fever virus E2 glycoprotein using pig antibodies identifies residues contributing to antigenic variation of the vaccine C strain and group 2 strains circulating in China
... the antigenic variation seen with subgroup ...the antigenic motif 771 LLFD 774 that disrupted the structural integrity of E2 protein [25], none of the substitutions had a significant effect on ...
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Redefining the expressed prototype SICAvar gene involved in Plasmodium knowlesi antigenic variation
... The recent availability of a P. knowlesi genome sequence database is a much-welcomed tool, which has proved to be invaluable towards understanding the organization and evolution of SICAvar genes in this species. The ...
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Mosaic VSGs and the Scale of Trypanosoma brucei Antigenic Variation
... to antigenic variation because the boundaries of conversion occur within the buried CTD ...of antigenic variation, the infection is likely to progress to this phase sooner, as the ...
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Capsule Structural Heterogeneity and Antigenic Variation in Cryptococcus neoformans
... Cryptococcus neoformans is a human pathogenic fungus with a capsule composed primarily of glucuronoxy- lomannan (GXM) that is important for virulence. Current views of GXM structure postulate a polymer composed of ...
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Antigenic Divergence Suggested by Correlation between Antigenic Variation and Pulsed Field Gel Electrophoresis Profiles of Bordetella pertussis Isolates in Japan
... Antigenic divergence has been found between Bordetella pertussis vaccine strains and circulating strains in several countries. In the present study, we analyzed B. pertussis isolates collected in Japan from 1988 ...
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Antigenic variation of influenza A virus nucleoprotein detected with monoclonal antibodies.
... Viruses of other influenza A virus subtypes showed antigenic variation in these nucleoprotein determinants, although changes in only one determinant were detected in HON1 and animal stra[r] ...
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A Similar Pattern of Interaction for Different Antibodies with a Major Antigenic Site of Foot-and-Mouth Disease Virus: Implications for Intratypic Antigenic Variation
... intratypic antigenic di- versity of ...on antigenic site A of FMDV of serotype C (32) showed distinct degrees of conservation during the natural evolution of the virus in the ...of antigenic ...
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Antigenic variation at the vlsE locus of the lyme disease spirochete, Borrelia burgdorferi
... all. Variation is achieved through switching one of several gene alleles expressed at any one time, rather than accumulating mutations in a single expressed ...gene. Antigenic variation can happen ...
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Human Antibody Responses to VlsE Antigenic Variation Protein of Borrelia burgdorferi
... The sequence of the recombinant VlsE used in this assay was derived from a single variant from B. burgdorferi clone B31- 5A3. The discovery that the antibodies reactive with this form of VlsE could be detected in the ...
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Mechanisms of Surface Antigenic Variation in the Human Pathogenic Fungus Pneumocystis jirovecii
... of antigenic variation in different human ...of antigenic variation unraveled here appear unique among human ...of antigenic variation of ...
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A Homologue of the Recombination-Dependent Growth Gene, rdgC, Is Involved in Gonococcal Pilin Antigenic Variation
... pilin antigenic variation were localized to three genes in one region of the Gc ...phase variation and in pilin antigenic ...pilin variation suggests a role for this protein in ...
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Strong Positive Selection and Recombination Drive the Antigenic Variation of the PilE Protein of the Human Pathogen Neisseria meningitidis
... positive selection at amino acid sites. Genetics 164: 1229–1236. Perry, A. C., I. J. Nicolson and J. R. Saunders, 1988 Neisseria Brayton, K. A., G. H. Palmer, A. Lundgren, J. Yi and A. F. Barbet, meningitidis C114 ...
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Norovirus GII.4 Strain Antigenic Variation
... extensive antigenic relationships between norovirus strains and how this heterogeneity affects host protective ...undergoing antigenic variation over time, most likely in response to human herd ...
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Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant Specific Immunity
... sequence variation and hot spots of re- combination in surface proteins of Streptococcus ...sequence variation within the ...quence variation within pspC reflects differences in biological ...that ...
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Antigenic Variation in Plasmodium falciparum: Gene Organization and Regulation of the var Multigene Family
... that antigenic variation take place at a rate sufficient to maintain infection in face of the acquired host immune response, but not so rapidly that the repertoire is exhausted before the parasite can be ...
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Antigenic variation of core, NS3, and NS5 proteins among genotypes of hepatitis C virus
... HCV can be classified into at least six major genotypes, whose nucleotide and inferred amino acid sequences over the whole genome differ by approximately 30%. This degree of amino acid sequence variability is similar to ...
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Antigenic Variation in Bacteroides forsythus Detected by a Checkerboard Enzyme-Linked Immunosorbent Assay
... Data rescaling was not necessary in the present application because of the observed close agreement in comparable re- peated absorbance measurements of pooled isolate and serum controls rows on different assay plates, ...
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Effects of recA Mutations on Pilus Antigenic Variation and Phase Transitions in Neisseria gonorrhoeae
... Pilin gene nucleotide (underneath) and encoded amino acid positions (above) are according to BERGSTROM et al. On the top is shown the mRNA sequence determined for the VD3[r] ...
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