Antineoplastic Agents
DETERMINATION AND ASSAY OF SOME ANTINEOPLASTIC AGENTS IN PURE FORM AND IN THEIR PHARMACEUTICAL PREPARATIONS USING TITRIMETRIC METHOD
... neoplasms. Antineoplastic agents travel the body and destroy cancer ...with antineoplastic agents occur because treatment destroys the body's normal cells in addition to cancerous ...some ...
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Evaluation of the permeation of antineoplastic agents through medical gloves of varying materials and thickness and with varying surface treatments
... 4.6-fold higher than that of 5FU. The difference appears to predominantly reflect the difference in logP between CPA and 5FU, because the magnitude of difference be- tween CPA and 5FU is larger for logP compared with the ...
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In Vitro Evidences of Discret Alterations in the Bacterial Resistance/Susceptibility Profiles Induced by Antineoplastic Agents
... Nyhlen et al. (14, 15) evaluated the synergic antimicrobial potential of 5-FU and some antibiotics in S. aureus, S. epidermidis, P. aeruginosa, and E. coli. They proposed that 5-FU does not interfere in the ...
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PYRIMIDINE METABOLISM IN MAN V THE MEASUREMENT IN VIVO OF THE BIOCHEMICAL EFFECT OF ANTINEOPLASTIC AGENTS IN ANIMAL AND HUMAN SUBJECTS
... index of pyrimidine biosynthesis, at least three postulates must be confirmed by experimental data: 1 C'402 should be released more rapidly from precursors when the label is in the carbo[r] ...
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Biochemical aspects of the combined use of taxanes, irradiation and other antineoplastic agents for the treatment of anaplastic thyroid carcinoma
... The action of IR caused inactivation of another tumor suppressor – retinoblastoma protein (pRb), which occurred through cascade phosphorylation of pRb by cyclin/CDK complexes and in turn re- sulted in the release of E2F ...
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BERBERINE, COPTIDIS RHIZOMA AND DIOSPYRIN AS NOVEL ANTINEOPLASTIC AGENTS: A REVIEW ON TRADITIONAL USE AND BIOMEDICAL INVESTIGATIONS
... the antineoplastic story of berberine, are based on the knowledge of cell-cycle regulation and the downstream effects or phenotypes related to cell-cycle inhibition, particularly the caspase(s)-dependent apoptosis ...
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Nanoparticles Mediated Targeted Drug Delivery System of Some Antineoplastic Agents for the Treatment of Breast Cancer.
... Li C et al 2008 provide the update on polymer-drug conjugates that had advanced into clinical trials. The polymer-drug conjugate drug delivery aimed at increased therapeutic index by making more drug molecules available ...
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Rational drug design of antineoplastic agents using 3D QSAR, cheminformatic, and virtual screening approaches
... QSAR methods have been widely applied in medicinal chemistry in order to gain insight into the critical structural requirements for compounds to interact with the biomolecules of interest. This computational tool uses ...
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Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy
... chemotherapeutic agents highlight the urgent need for the identification of new adjuvant ...Such agents will act synergistically to sensitize tumor cells to the currently approved anticancer agents, ...
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Downregulation of Scar Fibroblasts by Antineoplastic Drugs: A Potential Treatment for Fibroproliferative Disorders
... of antineoplastic agents on arresting fibroblasts, evidence shows that these cells remain ca- pable of migration and continue to produce regulatory proteins inclusive of growth factors and extracellular ma- ...
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Relationship between the effects of food on the pharmacokinetics of oral antineoplastic drugs and their physicochemical properties
... predicted based on the BCS class [6]. Class 1 drugs with high solubility/high permeability; high-fat meal will have no significant effect on drug bioavailability, Class 2 drugs with low solubility/high permeability; ...
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BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo
... is one of the BCc1 antineoplastic mechanisms that induces cell cycle arrest and apoptosis. Evaluations of mice bearing adenoma carcinoma of the breast revealed that BCc1 was able to increase the survival rates and ...
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Neuromuscular Blocking Agents. Neuromuscular Blocking Agents. Neuromuscular Blocking Agents. Neuromuscular Blocking Agents
... Antiarrhythmic Agents • Class I – Sodium Channel Blockers. – Depress the fast inward sodium currents in myocardial cells to suppress their automaticity and increase resting potenti[r] ...
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Evaluation of the Antineoplastic Activity of L-rhamnose in vitro. A Comparison with 2-deoxyglucose
... Using 2-DG for comparison, we studied the effect of L-rhamnose in concentrations up to 20 (32 resp.) mmol/l on the in- itial velocity of the incorporation of labeled precursors of DNA an[r] ...
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PHYTOCHEMICAL ANALYSIS, ANTIOXIDANT AND IN VIVO ANTINEOPLASTIC PROPERTIES OF CARICA PAPAYA FRUITS
... Oxidative stress, based on imbalance between pro-oxidants production and antioxidant defenses is involved in several human chronic diseases such as cancer, diabetes mellitus and coronary heart disease. This study sought ...
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Stereocomplex micelle from nonlinear enantiomeric copolymers efficiently transports antineoplastic drug
... free DOX · HCl toward RenCa cells were evaluated by a MTT assay. As depicted in Figure 7A, blank micelles did not show obvious toxicities toward RenCa cells even at a high concentration up to 100.0 μg mL −1 after ...
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Simvastatin increases the antineoplastic actions of paclitaxel carried in lipid nanoemulsions in melanoma-bearing mice
... The groups of animals treated with PTX associated with LDE (LDE-PTX and Simva and LDE-PTX) or with PTX alone presented increased survival rates in comparison with the control[r] ...
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CAROTENOID PROFILE OF AILANTHUS ALTISSIMA STEM BARK, IN VITRO ANTIOXIDANT AND ANTINEOPLASTIC ACTIVITIES
... Ailanthus altissima (Mill.) Swingle (tree of heaven) is a fast-growing invasive species for Bulgaria and Europe and it belongs to the family Simaroubaceae. Carotenoid fraction from stem bark of Ailanthus altissima was ...
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New Green Synthesis and Antineoplastic Activity of Bis (3 Arylimidazolidinyl 1) Methanes
... A new green synthesis and anti-tumor activity of the series of bis (3-arylimidazolidinyl-1) methanes 1 - 6 are described. The compounds were synthesized from the corresponding N-arylethylenediamine and trioxane as ...
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Herbal mediated silver nanoparticles: A new horizon of antineoplastic drug delivery system
... Silver has its own importance in the field of medicine right from history. Hippocrates states in his writings about the use of silver in treating wounds. Before antibiotics were started, the colloidal silver was used as ...
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