Antisense oligonucleotide
STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial
... chemistry antisense oligonucleotide [24] de- signed to target and indirectly downregulate expression of human STAT3 protein by downregulating STAT3 ...
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Antisense oligonucleotide treatment ameliorates alpha 1 antitrypsin–related liver disease in mice
... an antisense oligonucleotide targeted against hAAT (AAT-ASO) and found reductions in circulating levels of AAT and both soluble and aggregated AAT protein in the ...tionally, antisense ...
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Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes.
... using antisense oligonucleotides complementary to the 5 * NCR, translation initiation codon, and core protein coding ...of oligonucleotide hybrid- ization. Chemically modified HCV antisense ...
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Antisense oligonucleotide–mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles
... Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited ataxia caused by expansion of a translated CAG repeat encoding a glutamine tract in the ataxin-1 (ATXN1) protein. Despite advances in understanding the ...
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Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl CoA desaturase–1
... SCD1-specific antisense oligonucleotide inhibitors (ASOs) reduced SCD1 expression, reduced fatty acid synthesis and secretion, and increased fatty acid oxidization in primary mouse ...
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Antisense oligonucleotide inhibition of hepatitis C virus genotype 4 replication in HepG2 cells
... using antisense oligonucleotide (ASO) technology, which inhibits gene expression by inducing cleavage of the target RNA at the site of oligonucleotide hybridization by an RNase H- mediated ...as ...
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Antisense oligonucleotide treatment ameliorates IFN-γ–induced proteinuria in APOL1-transgenic mice
... an antisense oligonucleotide (ASO) inhibitor of APOL1. Antisense technology is a powerful drug discovery approach for identifying oligonucleotide analogs that can specifically modify RNA ...
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Streptococcus mutans biofilm inhibition using antisense oligonucleotide to glucosyltransferases B and C
... test antisense oligonucle- otide (PS-ODN1) in combination with TurboFect ™ reagent caused a substantial decrease in bacterial aggregation as compared to the untreated bacteria, whereas missense ...
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Antisense oligonucleotide targeting Livin induces apoptosis of human bladder cancer cell via a mechanism involving caspase 3
... apply antisense oligonucleotide for Livin gene to investigate the effect of inhibition Livin expression on proliferation and apoptosis of human blad- der cancer cell 5637 in vivo and in vitro, and to ...
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Inhibition of IL-13 by Antisense Oligonucleotide Changes Immunoglobulin Isotype Profile in Cultured B-Lymphocytes
... development. Antisense oligo for human IL-13 m- RNA was used to study IgE down ...of antisense oligonucleotide. We demonstrated that IL-13 antisense causes the decrease of IgE and increase of ...
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Antisense oligonucleotide inhibition of Heat Shock Protein (HSP) 47 improves bleomycin-induced pulmonary fibrosis in rats
... of antisense oligonucleotide treat- ment on bleomycin-induced HSP47 production in ...that antisense oligonucleotides to HSP47 inhibit bleomycin-induced HSP47 ...
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Original Article Inhibitory effects of intrathecal p38β antisense oligonucleotide on bone cancer pain in rats
... was determined by Western blot. Results: No significant differences in mechanical withdrawal threshold and radi- ant heat threshold were found at all time points in control group. During the first 6 days after operation ...
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Hepatic and glucagon like peptide 1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
... Uncontrolled hepatic glucose production contributes significantly to hyperglycemia in patients with type 2 dia- betes. Hyperglucagonemia is implicated in the etiology of this condition; however, effective therapies to ...
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Antisense oligonucleotide–mediated MDM4 exon 6 skipping impairs tumor growth
... models, antisense oligonucleotide–mediated (ASO-mediated) skipping of exon 6 decreased MDM4 abundance, inhibited melanoma growth, and enhanced sensitivity to MAPK-targeting ...
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An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice
... mainly considered to favor asthma [16], despite recent evidence to the contrary [17]. It is difficult to account for the defensive properties of COX-2, with results pointing to increased activity of this enzyme in asthma ...
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The potential of antisense oligonucleotide therapies for inherited childhood lung diseases
... of antisense oligonucleotide therapy in CF Cystic fibrosis (CF) is a life-threatening, autosomal recessive genetic disease that affects multiple organs, caused by mutations in the gene encoding the CF ...
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Developing an antisense oligonucleotide treatment for Spinocerebellar Ataxia Type 3
... of antisense oligonucleotides for neurodegenerative disorders are encouraging but safe delivery, long term efficacy and side effects of prolonged treatment still need to be ...of antisense oligonucleotides ...
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Novel Targeted Therapy for Precursor B-Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate
... targets. Oligonucleotide-based technologies to down regulate these molecular targets have promising therapeutic ...an antisense oligonucleotide ...
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Block of AIDS Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor A novel strategy for the therapy of KS
... phosphorothioate antisense (AS) oligonucleotides directed against bFGF mRNA (ASbFGF) inhibit both the growth of AIDS-KS cells derived from different patients and the angiogenic activity associated with these ...
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Results of a proof of concept, double blind, randomized trial of a second generation antisense oligonucleotide targeting high sensitivity C reactive protein (hs CRP) in rheumatoid arthritis
... Abbreviations ACR20: American College of Rheumatology 20% improvement criteria; ACR50: American College of Rheumatology 50% improvement criteria; Cr: creatinine; CRP: C-reactive protein;[r] ...
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