antithrombin III
Molecular characterization of antithrombin III (ATIII) variants using polymerase chain reaction Identification of the ATIII Charleville as an Ala 384 Pro mutation
... Charleville is an Ala 384 Pro mutation. These two mutations impair the reactive site of the molecule. ATIII Charleville is a new mutation of the reactive center, as predicted by previous biochemical data. The position of ...
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Comparative study of routine diagnostic test, C-reactive protein with antithrombin III levels in diagnosis and prognosis of neonatal sepsis
... Antithrombin III is a natural anticoagulant that plays a pivotal role in coagulation. Recent data suggest that this glycoprotein also has potent anti-inflammatory properties, and it is protective in sepsis. ...
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Identification in vitro of an endothelial cell surface cofactor for antithrombin III Parallel studies with isolated perfused rat hearts and microcarrier cultures of bovine endothelium
... Platelet factor 4, protamine sulfate and diisopropylphosphoryl thrombin, all antagonists of the antithrombin III cofactor activity of heparin, significantly reduced the capacity of the p[r] ...
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Antithrombin III (AT) and recombinant tissue plasminogen activator (R-TPA) used singly and in combination versus supportive care for treatment of endotoxin-induced disseminated intravascular coagulation (DIC) in the neonatal pig
... Microscopic organ involvement. After staining with hematoxylin and eosin, piglet kidney histology specimens were evaluated microscopically in a blinded fashion by a single pathologist and assigned values on a scale from ...
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In vivo behavior of radioiodinated rabbit antithrombin III Demonstration of a noncirculating vascular compartment
... Rabbit antithrombin III (AT), purified by heparin-agarose, was labeled with iodine-131 by either the glucose oxidase-lactoperoxidase or iodine monochloride ...
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Interaction of antithrombin III with bovine aortic segments Role of heparin in binding and enhanced anticoagulant activity
... Bovine antithrombin III (AT III) interaction with the luminal surface of bovine aortic segments with a continuous layer of endothelium was ...125I-AT III with vessel segments, previously ...
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Antithrombotic properties in rabbits of heparin and heparin fragments covalently coupled to human antithrombin III
... Clinical grade heparin is a very heterogeneous mucopolysaccharide, containing molecules with Mr ranging from 6,000 to 30,000 that have either a high affinity or a low affinity for antithrombin III (AT). In ...
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Quality of life effects of antithrombin III in sepsis survivors: results from the KyberSept trial [ISRCTN22931023]
... intravenous antithrombin III treatment for severe sepsis measured for up to 90 days during the follow-up phase of the KyberSept phase III clinical ...and antithrombin III groups were ...
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Abnormal antithrombin III with defective serine protease binding (antithrombin III "Denver")
... of antithrombin III (AT-III) in which AT-III antigen (AT-III ag) is normal in spite of low heparin cofactor and antithrombin activity is ...progressive antithrombin ...
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Clot bound thrombin is protected from inhibition by heparin antithrombin III but is susceptible to inactivation by antithrombin III independent inhibitors
... Propagation of venous thrombi or rethrombosis after coronary thrombolytic therapy can occur despite heparin administration. To explore potential mechanisms, we set out to determine whether clot-bound thrombin is ...
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Inhibition of HCV by the serpin antithrombin III
... here antithrombin III (ATIII), a member of the serine protease inhibitor protein family (serpins), as its anti-inflammatory and anticoagulant activ- ities were found to decrease liver damage ...
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Clearance of Thrombin from Circulation in Rabbits by High affinity Binding Sites on Endothelium: POSSIBLE ROLE IN THE INACTIVATION OF THROMBIN BY ANTITHROMBIN III
... We propose that a thrombin in the circulation binds to active site-independent high-affinity binding sites on the endothelial cell surface; b the inactivation of thrombin by antithrombin[r] ...
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Antithrombin III in patients admitted to intensive care units: a multicenter observational study
... A MedLine search (PubMed, http://www.ncbi.nlm.nih.gov/ entrez/query.fcgi) was performed to cover the period from January 1980 to November 2001. The search was limited to the studies published in English and was based on ...
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Inherited Antithrombin III Deficiency and Cerebral Thrombosis in a Child
... Evaluation ofthe biologic activity, antigenic levels, and pattern of the protein on crossed immunoelectrophoresis (CIE) indicated a quantitative deficiency of AT-Ill in three family memb[r] ...
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Paper reports overview: Sepsis, insulin and noninvasive ventilation
... KyperSept Antithrombin III Study (see paper report) ...[antithrombin III] joins a long list of promising experimental agents for sepsis that failed to show a significant benefit in a ...
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Identification of disease states associated with coagulopathy in trauma
... as antithrombin III (ATIII), tissue factor pathway inhibitor (TFPI) and acti- vated protein C (APC) to bring the system back to its original state after the plug has been ...
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Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment response
... Amongst the 18 host markers that showed the most potential in the diagnosis of TB disease individually as determined by AUC, six (CRP, SAP, PCT, ferritin, TPA and SAA) were acute phase proteins, six (I-309, MIG, MIP-4, ...
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Close relationship of tissue plasminogen activator plasminogen activator inhibitor 1 complex with multiple organ dysfunction syndrome investigated by means of the artificial pancreas
... Methods: The amount of metabolized glucose (M value), as the parameter of GT, was measured by the euglycemic hyperinsulinemic glucose clamp method, in which the blood glucose level was clamped at 80 mg/dl under a ...
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Recombinant human soluble thrombomodulin improves mortality in patients with sepsis especially for severe coagulopathy: a retrospective study
... AT III: Antithrombin III; DIC: Disseminated intravascular coagulation; ICU: Intensive care unit; ISTH: Subcommittee of the International Society on Thrombosis and Haemostasis; JAAM: Japanese ...
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Structural Determinants of the Capacity of Heparin to Inhibit the Formation of the Human Amplification C3 Convertase
... antithrombin III and had essentially no anticoagulant activity. Nitrogen (N)-desulfation of porcine heparin reduced anticomplementary activity to the level of the other sulfated mucopolysaccharides, and ...
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