antitumor agent
<p>Improved Antitumor Outcomes for Colon Cancer Using Nanomicelles Loaded with the Novel Antitumor Agent LA67</p>
... enhanced antitumor activity and much higher con- centration in the tumor site, than did ...with antitumor agent, tumors exhibit the EPR effect, and drugs leak out from tumor vessels and accumulated ...
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Efficacy and Mechanistic Evaluation of Tic10, A Novel Antitumor Agent
... active antitumor agent that crosses the blood-brain barrier and transcriptionally induces TRAIL and TRAIL-mediated cell death in a p53-independent ...the antitumor activity of TIC10 through a ...
288
The Potent Effect of a Newly Synthesized N-Butylpyridoquinoxaline 1,4-dioxide(NBPQD) Derivative as Antitumor agent in solid tumor model
... as antitumor agent in Ehrlich ascites carcinoma (EAC) bearing mice in solid tumor ...as antitumor in solid tumor model was assessed by evaluating tumor volume and the contents of total protein, total ...
16
Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence
... the antitumor effects of new compounds is nec- essary for their clinical ...potent antitumor agent that is able to induce apoptosis in breast and colon cancer ...high antitumor activity and ...
13
Oxazepine Derivative as an Antitumor Agent and Snail1 Inhibitor against Human Colorectal Adenocarcinoma
... ABSTRACT: Colorectal cancer is the third most common malignancy in man, with significant morbidity and mortality. Metastasis, the major cause of cancer-associated deaths occurs as a multistep process, where cancer cells ...
7
Antitumor agent yatein from Calocedrus formosana Florin leaf induces apoptosis in non-small-cell lung cancer cells
... Previous studies are mainly focused on the anticancer potential of C. formosana extract alone or its major com- pound, hinokitiol [16, 19]. To our knowledge, thus far, no previous study focused on the screening of NSCLC ...
10
Bacteriophage T4 Mutants Hypersensitive to an Antitumor Agent That Induces Topoisomerase-DNA Cleavage Complexes
... Relationships between uvsX, uvsW, and mh The UvsXY recombination repair pathway is likely responsi- ble for repair of DNA damage resulting from mAMSA- induced topoisomeras[r] ...
10
QSAR Analysis on β-carboline as Antitumor Agent
... A quantitative structure activity relationship (QSAR) study on β-Carboline derivatives as an anti-tumor agent was performed with 30 compounds of β-Carboline derivatives on different cancer cell lines from reported ...
5
Navigating into the binding pockets of the HER family protein kinases: discovery of novel EGFR inhibitor as antitumor agent
... Abstract: The epidermal growth factor receptor (EGFR) family has been validated as a successful antitumor drug target for decades. Known EGFR inhibitors were exposed to distinct drug resistance against the various ...
15
Synthesis of 2,3,5 trisubstituted 1,2,4 triazine 6 ones as potential antitumor agent
... 1823 www derpharmachemica comt Available online a Scholars Research Library Der Pharma Chemica, 2015, 7(11) 214 225 (http //derpharmachemica com/archive html) ISSN 0975 413X CODEN (USA) PCHHAX 214 www[.] ...
12
Preparation and regeneration of protoplast from antitumor agent epothilone producing microbes myxobacteria
... This study showed that with the prolonging of enzymolysis time, the regeneration ratio protoplast decreased, and much too high concentrations of enzyme can also affect the regeneration r[r] ...
5
Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin- based “starvation” strategies in BRCA1 carriers
... The anti-diabetic biguanide metformin reduces tumor-initiating capacity of breast epithelial BRCA1 one-hit cells Because metformin has attracted interest as an antitumor agent in cancer [r] ...
19
Original Article Combined application of Doxorubicin and Naringin enhances the antitumor efficiency and attenuates the toxicity of Doxorubicin in HeLa cervical cancer cells
... ed. As shown in Figure 3, the mice treated with DOX showed about 20% of body weight lost at the end of treatment. Moreover, the mice of this group appeared to be much weak than other groups, which indicated the serious ...
9
Biological potential of Citharexylum myrianthum Cham. leaves in vitro and phenolic profile by HPLC-ESI-MS/MS
... Some of the phenolic compounds identified in both ME and DCMF have well established antitumor potential, especially hispidulin, which has been described as a potential antitumor agent[r] ...
7
Improved PCR-RFLP Method For Her-2 Ile655val Breast Cancer Patients Detection
... As an antitumor agent, treatment with trastuzumab mechanism is not fully understood. Tratsuzumab been reported to induce antibody dependent cellular toxicity (ADCC), inhibits the cleavage domain of ...
5
Theoretical Investigation on the Antitumor Drug: ThioTEPA and its Interaction with S-donor Biomolecules and DNA Purine Bases
... thioTEPA antitumor agent in confronting the sulfur-donor biomolecules (cysteine and methionine) and DNA purine bases (adenine and ...this antitumor drug among all biomolecules. So, the thioTEPA ...
13
Multi-agents Systems for Remote Control on Internet
... “Media” agent communicates with the camera in order to broadcast signals (video, images) of the mobile robot in its ...Selection Agent) and a reactive ...(Perception Agent) and the effectors (Action ...
6
“Synthesis of New Bis-Phthalimide and Thalidomide Ester Derivatives, and Evaluation of Their Cytotoxic Activity” by Amany Mostafa Ahmed Osman, Eman Abdel-Hamid Mansour, Magdy Abdel-Hamid Zahran, Erik B Pedersen, Egypt.
... their antitumor activity against MCF-7 and Hep-G2 ...significant antitumor activity. Phthalimide derivatives have antitumor activity higher than that of thalidomide derivatives, which supported the ...
8
Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo.
... A, Uninfected cells labeled with 32Pi and precipitated with antitumor serum; B, uninfected cells labeled with 32Pi and precipitated with absorbed antitumor serum; C, uninfected cells lab[r] ...
15
A formula-driven scalable benchmark model for ABM, applied to FLAME GPU
... Abstract. Agent Based Modelling (ABM) systems have become a pop- ular technique for describing complex and dynamic ...of agent-based appli- cations in the simulation and AI fields led to an increase in the ...
13