Antitumor immune response
α Tocopheryloxyacetic acid: a novel chemotherapeutic that stimulates the antitumor immune response
... the antitumor immune response, have galvanized interest in chemotherapeutic agents as immune modulators ...vivo antitumor effects of these ...vivo antitumor effects of a-TEA may ...
12
Neutrophil infiltration and whole-cell vaccine elicited by N-dihydrogalactochitosan combined with NIR phototherapy to enhance antitumor immune response and T cell immune memory
... systemic antitumor immune response or generate a long-term antitumor immune memory, in order to prevent the tumor relapse and metastasis, as shown in Figure 3B and ...of ...
19
Free ISG15 triggers an antitumor immune response against breast cancer: a new perspective
... establish antitumor innate immune response by activating/proliferating NK cells, and/or by inducing chemotaxis of the activated NK cells towards tumors in ...the immune system by enhancing ...
11
Tumor secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response
... the antitumor immune response by mimicking a physiolog- ic innate immune process — a form of innate immune checkpoint activity induced by paracrine secretion from the tumor ...The ...
15
Suppressing miR 21 activity in tumor associated macrophages promotes an antitumor immune response
... important immune cells that infiltrate the tumor and affect its pathology (71, ...some antitumor activity (73), they mostly promote a net protumor outcome because they have been shown to be capable of ...
20
Combination Therapy of TGF-β Blockade and Commensal-derived Probiotics Provides Enhanced Antitumor Immune Response and Tumor Suppression
... boost immune system in a more general way ...and immune cells in tumor microenvironment (TME), it may have quite limited effects on tumor cells expressing altered or non-functional TGF-β signal ...enhance ...
15
Gut microbiota modulate dendritic cell antigen presentation and radiotherapy induced antitumor immune response
... ily Clostridia (gram-positive bacteria), generating SCFAs such as C4, C3, and C2 (62). These SCFAs activate the G protein–coupled receptors GPR41, GPR43, GPR109a, and Olfr78, which are widely expressed in a variety of ...
15
Depleting tumor specific Tregs at a single site eradicates disseminated tumors
... temic antitumor immune response was obtained with a 100-fold lower dose of immunomodulatory mAbs if they were administered locally into the ...adaptive antitumor immune ...systemic ...
18
Immunosuppressive effect of bladder cancer on function of dendritic cells involving of Jak2/STAT3 pathway
... Function of dendritic cells (DCs) is impaired by some cancer cells. However, the effect of bladder cancer cell (BCC) on phenotype and function of DCs remains unclear. In this study, healthy human peripheral blood ...
11
Nanocarrier-based immunotherapy in cancer management and research
... DCs are key players in an effective antitumor immune response and can be manipulated in different ways to enable them to prime tumor-specific T-cells. This can be done by ex vivo loading of DCs with ...
14
The emerging therapeutic potential of the oncolytic immunotherapeutic Pexa-Vec (JX-594)
... Abstract: Oncolytic immunotherapeutics (OIs) are viruses designed to preferentially replicate in and lyse cancer cells, thereby triggering antitumor immunity. Numerous oncolytic platforms are currently in clinical ...
7
Oncolytic adenovirus coexpressing interleukin-12 and shVEGF restores antitumor immune function and enhances antitumor efficacy
... adaptive immune responses against cancer [47], making IFN-γ a key mediator of the antitumor-immune ...enhance antitumor immunity by more potently downregulating VEGF expression (Figure ...
16
Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer
... the antitumor efficacy of our proposed combinatorial triple therapy in which vaccine is combined with two check- point ...potent antitumor immune response and durable tumor clearance in ...
16
Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma
... specific response have provided proof for the rationale of immunotherapy in cancer, both in animal models and in ...an antitumor immune response and selected clinical studies of ipilimumab in ...
12
Targeting the tumor microenvironment to enhance antitumor immune responses
... various immune promoting ...evoke antitumor immune responses capable of mediating regression of established tumors, including the weakly immunogenic B16 ...therapeutic antitumor immune ...
23
The Role of GABA Signalling in Lung Macrophage Immune Response
... in response to different environmental ...other immune cells to the site of infection (Murugan & Peck, 2009; Jablonksi et ...dominant response in allergy, asthma, and parasite infections ...
118
In Vivo and In Vitro Immunomodulatory Effects of Indian Ayurvedic Herbal Formulation Triphala on Experimental Induced Inflammation
... cellular immune response (CIR), such as an increase in interleukin-1 production by macrophage, as well as a decrease in functions of suppresser T cells ...humoral immune response and cell ...
10
<p>Comprehensive Analysis of PD-1 Gene Expression, Immune Characteristics and Prognostic Significance in 1396 Glioma Patients</p>
... In fl ammation was closely associated with the initiation, progression and metastasis in many tumors 16,17 and we also found that PDCD1-related genes were closely asso- ciated with in fl ammatory responses in glioma ...
12
Th9 cells promote antitumor immune responses in vivo
... To investigate whether the protection of tumor-specific Th9 cells was limited to tumor located in the lung, we used the s.c. B16-OVA model. OVA-specific Th1 or Th9 cells were injected s.c. on the same day and at the same ...
13
Looking beyond the cancer cell for effective drug combinations
... It is conceivable that in the not so distant future there will be enough data at the patient level to generate stat- istical models that take into account multiple modes of drug action and the many pathways involved in ...
13