Antiviral Agents
Recent developments in antiviral agents against enterovirus 71 infection
... The proposed EV-71 uncoating event involves attach- ment to the entry receptor, triggering a series of con- formational changes resulting in A-particle formation that is primed for genome release. A second uncoating ...
11
A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents
... experimental antiviral agents. Many of these agents cause serious side effects, which can be revealed only after drug ...of antiviral agents, which could be associated with potential ...
13
New strategies for the treatment of hepatitis C virus infection and implications of resistance to new direct-acting antiviral agents
... Abstract: Persistent hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma and the major indication for liver transplantation in adults. Current standard of ...
13
Design, Chemical Synthesis and Biological Evaluation of Potential New Antiviral Agents
... The scaffold present in the series of the new molecules derives from the disconnection of (+)- calanolide A, a natural product isolated from the Malaysian tree Calophyllum lanigerum, showing a potent anti-HIV activity ...
190
Prevalence of resistance-associated substitutions to direct-acting antiviral agents in hemodialysis and renal transplant patients infected with hepatitis C virus
... Direct-acting antiviral agents (DAAs) permit the use of interferon (IFN)-free regimens to treat hepatitis C (HCV) in patients with chronic kidney disease (CKD) on hemo- dialysis (HD) or renal transplant ...
8
Cost per care of the first year of direct antiviral agents in the Liguria Region: a multicenter analysis
... Our study is not without its limitations. For instance, treat- ment costs for other antiviral agents in coinfected patients were not considered. Similarly, costs for radiology/ultrasound examination or ...
13
Pharmacogenetics of hepatitis C: transition from interferon-based therapies to direct-acting antiviral agents
... direct antiviral agents such as protease inhibitors, polymerase inhibitors, or NS5A inhibitors have been used to augment PEGylated interferon and ribavirin, resulting in better efficacy, bet- ter tolerance, ...
17
New thiopyrano[2,3-d][1,3]thiazole derivatives as potential antiviral agents
... efficient antiviral agents is an impor- tant worldwide problem among scientists and clini- cians, because of rapid emergence of drug resistant ...current antiviral drugs and to obtain more ...
8
Long term follow up of HCV infected kidney transplant recipients receiving direct acting antiviral agents: a single center experience in China
... Either poor efficacy or high prevalence of adverse ef- fects have limited the use of pegylated interferon (IFN)- based regimens, especially for kidney transplant recipi- ents, which may potentially trigger off an ...
6
Simultaneous determination of newly developed antiviral agents in pharmaceutical formulations by HPLC-DAD
... region. In Saudi Arabia, HCV-genotype 4, followed by genotype 1, are the most prevalent [3, 5]. Increasing pro- tective immune responses in human beings is difficult using classic approaches for virus control. As a ...
8
Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents
... Efforts are currently in progress to investigate the use of nilotinib and imatinib, two marketed TKIs, as antiviral agents employing the above-indicated animal species. As an important first step, we ...
11
Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral Agents
... and antiviral drugs are the most powerful tools to combat viral ...broad-spectrum antiviral agents (BSAAs, ...safe-in-man agents in freely accessible database ...
25
Nephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailand
... The records of all patients with CHB were reviewed from the time that antiviral treatment was started. Pa- tients were identified by their attendance at the out- patient hepatology clinic and by searches of the ...
9
Pyrophosphate analogues as antiviral agents
... Many D N A and R N A polymerases arc zinc-requiring enzymes19,20 and we propose that phosphonoacetic, phosphonoformic and methylcnebisphosphonic acids act by complexing with this zinc ion preventing the release of ...
201
Potent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16
... Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) are the two major causative agents of hand, foot and mouth disease (HFMD), for which there are currently no licenced treatments. Here, the acquisition of ...
6
Direct acting antiviral agents in the therapy of hepatitis C virus related mixed cryoglobulinaemia: a single centre experience
... early antiviral approach with DAAs, before the occurrence of severe organ damage, might be able to prevent the occurrence of these initially virus-induced and then virus-cleared vasculitides remains to be ...
10
SYNTHESIS OF SOME NEW PYRIMIDO[4,5 B][1,6]NAPHTHYRIDIN AND THEIR BIOLOGICAL EVALUATION AS ANTICANCER AND ANTIVIRAL AGENTS
... with the synthesis of a series of pyrimido[4,5-b][1,6]naphthyridine ring systems carrying some biologically active rings such as thienyl, 1,3-Benzodioxolyl and fluorinated aryl groups. The aim of the study was to ...
14
Consequences of inaccurate hepatitis C virus genotyping on the costs of prescription of direct antiviral agents in an Italian district
... further antiviral treatments and monitoring for patients not reaching SVR in the LiPA-HCV genotype assay ...the antiviral treatments considered (assuming similar safety profiles), which would, however, ...
7
Hepatitis C in healthcare personnel: secondary data analysis of therapies with direct-acting antiviral agents
... Direct-acting antiviral agent; DSV: Dasabuvir; ETR: End-of-treatment sustained virological response rate; GECCO: German Hepatitis Cohort; HBV: Viral hepatitis B; HCV: Viral hepatitis C; HIV: Human immunodeficiency ...
8
Thiazolides, a New Class of Antiviral Agents Effective against Rotavirus Infection, Target Viral Morphogenesis, Inhibiting Viroplasm Formation
... Rotaviruses, nonenveloped viruses presenting a distinctive triple-layered particle architecture enclosing a segmented double- stranded RNA genome, exhibit a unique morphogenetic pathway requiring the formation of ...
11