Antiviral defense
Mosquito antiviral defense mechanisms: a delicate balance between innate immunity and persistent viral infection
... mosquito antiviral response ...an antiviral defense with a defective siRNA pathway, indicating the redundancy of RNAi-mediated antiviral immune responses ...in antiviral immunity ...
12
Cellular Proteins PML and Daxx Mediate an Innate Antiviral Defense Antagonized by the Adenovirus E4 ORF3 Protein
... IFN-induced antiviral state was ...IFN-induced antiviral state exerted only a modest effect upon Ad early gene transcription that was not sufficient to inhibit early protein ...additional antiviral ...
11
RDR6 Has a Broad-Spectrum but Temperature-Dependent Antiviral Defense Role in Nicotiana benthamiana
... ing-based antiviral defense operating in the plant shoot ...the antiviral defense in differentiated leaf tissue for each of the three vi- ruses tested, although there was evident variation in ...
9
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors.
... crossing A129 mice with G129 mice, double-knockout mice were generated. These double-knockout mice (AG129) were healthy by 12 months of age and showed no gross abnormali- ties in hematological status, in the major ...
5
Variations in Hypovirus Interactions with the Fungal-Host RNA-Silencing Antiviral-Defense Response
... We recently demonstrated that an inducible RNA-silencing pathway consisting of a single Dicer protein, DCL2, and a single Argonaute protein, AGL2, serves as an effective antiviral defense response in C. ...
7
Cross Talk between PML and p53 during Poliovirus Infection: Implications for Antiviral Defense
... PML nuclear bodies (NBs) are dynamic intranuclear structures harboring numerous transiently or perma- nently localized proteins. PML, the NBs’ organizer, is directly induced by interferon, and its expression is critical ...
11
A chemokine to cytokine to chemokine cascade critical in antiviral defense
... The experiments presented here define roles for MIP- 1α and the MIP-1α–dependent NK cell liver inflam- mation in the regulation of endogenous responses and protection during MCMV infections. The studies demonstrate that ...
10
Nuclear Domain 10 Components Promyelocytic Leukemia Protein and hDaxx Independently Contribute to an Intrinsic Antiviral Defense against Human Cytomegalovirus Infection
... Infection with DNA viruses commonly results in the association of viral genomes with a cellular subnuclear structure known as nuclear domain 10 (ND10). Recent studies demonstrated that individual ND10 compo- nents, like ...
12
Extraribosomal L13a Is a Specific Innate Immune Factor for Antiviral Defense
... using macrophage-specific L13a ⫺/⫺ mice confirmed and ex- tended the role of the GAIT mechanism as an endogenous defense against uncontrolled inflammation (16). It is to be mentioned that the ribosomal loss of ...
11
An Evolutionarily Conserved Role for Autophagy in Antiviral Defense
... Interestingly, and perhaps importantly, many of the viruses restricted by autophagy infect neurons, including SINV and HSV-1, as well as RVFV identified in this study. Moreover, some cells rely more heavily on ...
142
Hepatitis A Virus Inhibits Cellular Antiviral Defense Mechanisms Induced by Double-Stranded RNA
... cell-based antiviral responses and the interac- tions between virus and host cells resulting in persistent infections are poorly ...cellular defense mechanisms might not be sufficient to completely prevent ...
11
Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I
... A new model for virus activation of IFN- ␣ /  and ISGs. We propose a model in which within the infected hepatocyte RIG-I binding to the HCV RNA PAMP induces events that are regulated by its helicase domain and alter its ...
11
Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis.
... preferential induction of the protective helper lymphocytes with a TH1 cytokine profile constitutes an important parame- ter in the pathogenesis of murine MV encephalitis. The gen- eration of a TH1 response is essential ...
6
Design and engineering of a transmissible antiviral defense
... Cells were infected by the ampicillin-resistant phagemid (vaccine) at an MOI of 1.0 (phagemid stock also contained a low concentration of helper phage at MOI 0.01) and grown for the time[r] ...
16
Interferon Induced IFIT Family Genes in Host Antiviral Defense
... nonspecific antiviral program through their direct interactions with eIF3, which subsequently suppresses more than 60% of translation in cells and viruses during protein syn- thesis (Figure 4) ...
9
Inhibition of IFN-γ-dependent antiviral airway epithelial defense by cigarette smoke
... affect antiviral defense ...mediated antiviral defense against hepatitis C virus in human hepatocytes and enhance RSV replication in human airway epithelial cells ...airway defense in ...
18
Age-Dependent Role for CCR5 in Antiviral Host Defense against Herpes Simplex Virus Type 2
... early defense against many viruses, including herpesvi- ruses (2, 23, 28), and Salazar-Mather et ...impaired antiviral defense. When we examined the innate antiviral re- sponse at the site of ...
11
Defense and counter-defense in rice–virus interactions
... effective defense re- sponses against virus as well as to balance defense and ...plant defense through its effects on virus infection and more atten- tion has been paid to the study of SA on ...
6
Department of Defense
... There was little evidence of oversight by Air Force Logistics Command Headquarters to ensure that the air logistics centers performed follow-on analysis (sustainmen[r] ...
52
Department of Defense
... The four organizations audited were the Defense Information Services Organization (DISO) Information Processing Center in Kansas City, Missouri (DISO-Kansas City); the [r] ...
54