Antiviral efficacy
Reduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug Resistance
... The idea that host-based nucleoside uptake defects can af- fect antiviral efficacy may have clinical relevance. Similar to cancer patients undergoing chemotherapy, chronically infected hepatitis C patients ...
10
Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity
... HSV-1 antiviral, by itself does not block HSV-1 replication as effectively as DE1 or DE2 ...high antiviral efficacy of DE1 and DE2 to the combinations acting on multiple cellular signaling networks ...
12
Antiviral efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV-infected children and adolescents: a systematic review protocol
... the antiviral efficacy and safety of abacavir-containing combination antiretroviral therapy as first-line treatment of HIV-infected children aged between 3 months and 18 years, compared with other ...
6
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
... the antiviral strategy we have outlined represents a paradigm different from classical antiviral approaches, since we are not actu- ally directly targeting a viral ...
9
Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection
... Anti-influenza efficacy study was performed in mice. Groups of six 6-week-old female BALB/c mice were purchased from the National Laboratory Animal Center, Taipei, Taiwan. Mice were infected with a nonlethal dose ...
15
Antiviral efficacy of entecavir for hepatitis B virus rtA181V/T mutants
... Hepatitis B virus (HBV) infection is a major health prob- lem that caused over 350 million people suffering chronic infection worldwide [1, 2]. Nucleos(t)ide analogs (NAs) in- cluding lamivudine (LAM), adefovir dipivoxil ...
5
The antiviral role of cytokines
... The Enhancement of the in vivo Antiviral Efficacy of human Tumour Necrosis Factor alpha hTNF a by Antibodies in Vaccinia Virus Infection... There has been much interest recently on the p[r] ...
226
CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity.
... The antiviral efficacy of the purified CD8+ CD4- subset was not impaired by preincubation with fibroblasts that presented viral structural antigens, but was significantly reduced after d[r] ...
7
Computational Design of Antiviral RNA Interference Strategies That Resist Human Immunodeficiency Virus Escape
... in efficacy with siRNA expression heterogeneity that was observed at low levels of RNAi as well as the modest decrease in efficacy observed for higher levels of RNAi; in other words, if a cell population ...
10
Not All Cytokine-Producing CD8+ T Cells Suppress Simian Immunodeficiency Virus Replication
... in antiviral efficacy among epitope-specific CD8 ⫹ T cells in HIV or SIV infection has not, until now, been comprehensively ...the antiviral efficacy of epitope-specific CD8 ⫹ T-cell clones, ...
7
Pharmacological Investigation of Ethanolic Extract of Roots of Holoptelea Integrifolia (Roxb )Plench
... , antiviral efficacy was undertaken by using plaque inhibition method and antineoplastic activity was tested by using Sarcoma 180A 0 as the test system ...antifungal efficacy but failed to ...
5
Efficacy and safety of abacavir containing combination antiretroviral therapy as first line treatment of HIV infected children and adolescents: a systematic review and meta analysis
... The primary objective of this review was to assess the antiviral efficacy of abacavir-containing combination antiretroviral therapy cART regimens in comparison with cART regimens contain[r] ...
13
Long term follow up of HCV infected kidney transplant recipients receiving direct acting antiviral agents: a single center experience in China
... Both Tac and CyA are substrates of liver cytochrome (CYP) P450 isoforms 3A4. Given the limited impact on CYP3A4 of SOF, LDV and DCV, no clinically relevant drug-to-drug interactions are expected when SOF, LDV or DCV ...
6
Cyclosporine and Hepatitis C
... By binding to host proteins, CsA is thought to mediate its antiviral effects. Other investigators further report that CypA is the isoform that serves as the essential cofactor for HCV replication and that the ...
5
Efficacy and safety of sofosbuvir based antiviral therapy for chronic hepatitis C infection in patients with advanced chronic kidney disease
... acting antiviral drugs has revolutionized treatment of hepatitis C even in difficult ...the efficacy and safety of Sofosbuvir based DAAs in patients with advanced ...
6
Safety and anti-HIV assessments of natural vaginal cleansing products in an established topical microbicides in vitro testing algorithm
... the efficacy and cytotoxicity of these substances using an established topical microbicide testing ...for efficacy and cytotoxicity in the CCR5-tropic cell-free entry and cell-associated transmission ...
13
Anti HSV 2 activity of Terminalia chebula Retz extract and its constituents, chebulagic and chebulinic acids
... glycosaminoglycans. Antiviral activity of che- bulagic acid and punicalagin was significantly reduced in mutant cell lines deficient for heparan sulfate and chon- droitin sulfate suggesting that these tannins may ...
11
A Neonatal Murine Model of Coxsackievirus A6 Infection for Evaluation of Antiviral and Vaccine Efficacy
... but antiviral activity in vivo was completely ...showed antiviral efficacy and promoted an increase in the survival rates of infected 5-day-old ...IFN antiviral therapies can be used singly or in ...
18
COVID-19 – Time is now
... Direct antiviral activity of CQ has been identified against a range of no less than thirty viruses mostly by in vitro studies (Rolain et ...an antiviral (Al-Bari, ...
26
Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen
... its antiviral activity for up to 2–3 hours after HIV-1 inoculation, blocks an early step in the HIV-1 infection cycle, acts nonspecifically toward Env- and CD4-expressing cells in a dose-dependent manner (although ...
8