Antiviral response induced by interferon
The Antiviral Response to Gamma Interferon
... all induced genes ...the induced expression of IFN- and IFI56K mRNAs as indices of at least two distinct dsRNA response ...in response to virus, both dsRNA response pathways leading to ...
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The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins
... if antiviral mechanisms or ISGs were altered in the ISG20-expressing ...as antiviral or inducible by type I or II IFN ...were induced, including the ubiquitin-like Isg15, the ISG15 E3 ligase, Herc6, ...
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Negative Regulation of the Alpha Interferon-Induced Antiviral Response by the Ras/Raf/MEK Pathway
... lators of the IFN response. In this study, we have found that activation of the Ras/Raf/MEK pathway downregulates IFN- induced antiviral responses. Since Ras/Raf/MEK signaling reg- ulates cell ...
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Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon
... independently induced by viral infection, but IFN- may specifically induce one or more genes that are required for full antiviral ...whose antiviral activity has been well studied [38]) that are ...
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Interferon Induced IFIT Family Genes in Host Antiviral Defense
... host antiviral immunity and in fact, IFNs exert their antiviral activities through the induction of antiviral ...predominantly induced by type I and type III interferons and are regulated by ...
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Gamma Interferon-Induced Interferon Regulatory Factor 1-Dependent Antiviral Response Inhibits Vaccinia Virus Replication in Mouse but Not Human Fibroblasts
... DISCUSSION VACV is relatively resistant to type I IFN in most cells (52). Here, we document a fundamental difference in the ability of mouse and human fibroblasts to prevent VACV replication upon IFN- ␥ but not IFN-␣/ ...
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Adaptation to the Interferon-Induced Antiviral State by Human and Simian Immunodeficiency Viruses
... I interferon (IFN) is an early host response to different infectious agents leading to the induction of hun- dreds of IFN-stimulated genes ...an antiviral state is induced by IFN- ␣ ...the ...
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Membrane Perturbation Elicits an IRF3-Dependent, Interferon-Independent Antiviral Response
... same response can be induced by a purified viral fusion protein indicates that this response is not triggered by virus pattern-associated mo- lecular patterns such as nucleic ...this response, ...
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Adenovirus E4 ORF3 Protein Inhibits the Interferon-Mediated Antiviral Response
... an interferon (IFN)-stimulated gene, implicating the participation of this nuclear body in an innate antiviral ...IFN-induced antiviral state. Furthermore, E4 ORF3 inhibition of an ...
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Varicella-Zoster Virus IE63, a Major Viral Latency Protein, Is Required To Inhibit the Alpha Interferon-Induced Antiviral Response
... The observations that VZV IE63 reduces the level of eIF- 2 ␣-P and that VZV with ORF63 deleted is markedly impaired for growth in the presence of IFN- ␣ have important implica- tions for VZV pathogenesis. IE63 is ...
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Activation of type I interferon antiviral response in human neural stem cells
... trigger antiviral innate immune responses, such as the produc- tion of type I ...responses induced by a virus could be different among cell ...downstream antiviral ISGs, such as ISG56 and MxA, in ...
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Innate STAT1-Dependent Genomic Response of Neurons to the Antiviral Cytokine Alpha Interferon
... genomic response of neurons to IFN- ␣ , we undertook studies both in vitro and in ...attenuated response genes, IFN- induced GTPases, and the chemokine ...genomic response of neurons to IFN- ␣ ...
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Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response
... DISCUSSION Antiviral therapy for HCV infection is still rather primitive, with only two Food and Drug Administration-approved drugs ...of antiviral intervention in HCV, it is important to understand the ...
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Bovine Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Cooperatively Antagonize Alpha/Beta Interferon-Induced Antiviral Response
... A series of proteins from diverse DNA viruses (reviewed in reference 35) and RNA viruses (14, 20, 21, 23, 24, 41, 42) with the ability to antagonize the effects of IFN have been de- scribed. Some viruses, like hepatitis ...
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Identification of Alpha Interferon-Induced Genes Associated with Antiviral Activity in Daudi Cells and Characterization of IFIT3 as a Novel Antiviral Gene
... In conclusion, our novel MTT AV/AP assay is the first to allow examination of IFN AP and AV activities simultaneously on a suspension cell line. This assay is compatible with a broad range of IFNs and is applicable to ...
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Human Parainfluenza Virus Type 4 Is Incapable of Evading the Interferon-Induced Antiviral Effect
... IFN response. To confirm the effect of hPIV4 V on IFN-induced signaling, we analyzed the biological activity of the hPIV4 V protein with re- spect to IFN-induced antiviral ...
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Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis.
... evidence for production of IL-4 in either strain was found by ELISA. Effect of antibodies against IFN- g and TNF- a . The influ- ence of IFN- g or TNF- a on the course of MV encephalitis in BALB/c mice, which are ...
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Activated Ras/MEK Inhibits the Antiviral Response of Alpha Interferon by Reducing STAT2 Levels
... the antiviral response as it was in vector control ...IFN response, we examined the responsiveness to IFN- ␣ of four independently generated RasV12/STAT2 cell lines ...IFN-induced ...
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Negative Feedback Regulation of RIG-I-Mediated Antiviral Signaling by Interferon-Induced ISG15 Conjugation
... an antiviral response that induces interferon (IFN) production, which, in turn, activates the transcription of RIG-I to increase RIG-I protein ...RIG-I-mediated antiviral response and ...
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More than meets the I: the diverse antiviral and cellular functions of interferon induced transmembrane proteins
... human antiviral immunity are components of the intrinsic immune response that reside within each and every one of our ...and antiviral effectors strategically placed by evolution to detect and ...
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