Antiviral signaling
Negative Regulation of RIG-I-Mediated Innate Antiviral Signaling by SEC14L1
... in antiviral innate immunity, the activity of RIG-I must be tightly ...RIG-I-mediated antiviral signaling by preventing RIG-I interaction with the downstream ...
10
RNA- and Virus-Independent Inhibition of Antiviral Signaling by RNA Helicase LGP2
... inhibits signaling induced by expression of RIG-IN or by expression of IPS-1, both of which induce transcriptional responses independently of dsRNA treatments or virus ...IPS-1 signaling at a step ...
11
Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1
... vIRF-1 interacts with MAVS and inhibits MAVS aggregation. Recently, it was reported that MAVS may play an inhibitory role in HHV-8 productive replication (15). However, we previously showed that vIRF-1 has an opposite ...
15
Flavivirus Infection Impairs Peroxisome Biogenesis and Early Antiviral Signaling
... early antiviral signaling (8, 9). In keeping with an antiviral role for peroxisomes, it was recently reported that agonists, such as fenofibrate and re- lated compounds, that activate the ...
13
Low level expression of the Mitochondrial Antiviral Signaling protein (MAVS) associated with long term nonprogression in SIV infected rhesus macaques
... innate antiviral signaling ...MAVS-mediated antiviral signaling leads to dysfunction of mitochondria as well as cell apoptosis [53], which likely lead to the pathogenesis of ...natural ...
13
An Important Role for Mitochondrial Antiviral Signaling Protein in the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle
... RLR signaling during KSHV ...a signaling cascade that results in production of type I IFN and proinflammatory ...this signaling cascade is mitochondrial antiviral signaling protein ...
10
Human Immunodeficiency Virus Type 1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells
... intracellular signaling cascades in the infected cell that induce IFN expression and production to direct a cellular antiviral state mediated by ...have antiviral and/or immunomodulatory functions ...
11
The Emerging Duck Flavivirus Is Not Pathogenic for Primates and Is Highly Sensitive to Mammalian Interferon Antiviral Signaling
... agents. In nature, these viruses maintain a life cycle in vertebrates and/or arthropods, but accidental introduction into a new life cycle in humans results in unexpected diseases (48). The ability of the virus to cross ...
11
Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling
... Interferon signaling is the first line of defense to viral infection, and all of the interferons, their receptors and other key players in the interferon response are well conserved across vertebrates (Briolat et ...
15
Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA
... mitochondrial antiviral signaling protein (MAVS) (also known as IPS-1, VIAS, or Cardif) to the RIG-I-like receptor (RLR) signalosome; this leads to interferon beta (IFN-  ) production via activa- tion of ...
17
MAVS Self-Association Mediates Antiviral Innate Immune Signaling
... (mitochondrial antiviral signaling) to stimulate the phosphorylation and activation of the transcription factors IRF3 (interferon regulatory factor 3) and ...other signaling molecules identified in ...
9
Paramyxovirus V Protein Interaction with the Antiviral Sensor LGP2 Disrupts MDA5 Signaling Enhancement but Is Not Relevant to LGP2-Mediated RLR Signaling Inhibition
... and antiviral signaling in connection with MDA5 ...positive signaling responses, indi- cating the importance of ATP hydrolysis in LGP2-positive regu- lation (19), but this same LGP2 mutant retains ...
9
Herpes simplex virus 1 infection dampens the immediate early antiviral innate immunity signaling from peroxisomes by tegument protein VP16
... could induce other immediate early ISGs while VP16 inhibited all these ISGs (Fig. 4e). On the other hand, we investigated whether knockdown of VP16 would affect the induction of the immediate early ISGs during HSV-1 ...
8
Index Catalog // Carolina Digital Repository
... mitochondrial antiviral signaling ...other signaling proteins are recruited to the mitochondria where they interact with the mitochondrial antiviral signaling adaptor protein MAVS ...
177
Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors
... The trimeric RNA polymerase complex (3P, for PA-PB1-PB2) of influenza A virus (IAV) is an important viral determinant of pathogenicity and host range restriction. Specific interactions of the polymerase complex with host ...
13
The Role of Ubiquitination in Regulation of Innate Immune Signaling
... The mammalian immune system possesses remarkable abilities to precisely modulate defense mechanisms against invading pathogens, sensing when, where, and for how long defenses are needed. The immune system works in a ...
11
Hepacivirus NS3/4A Proteases Interfere with MAVS Signaling in both Their Cognate Animal Hosts and Humans: Implications for Zoonotic Transmission
... and signaling interference were observed in the case of cattle MAVS ...and signaling interference by their cognate hepaciviral NS3/4A proteases (NPHV ...no signaling interference was observed for the ...
12
HIV Exploits Antiviral Host Innate GCN2 ATF4 Signaling for Establishing Viral Replication Early in Infection
... host antiviral restrictive response for establishing its ...GCN2-ATF4 signaling mainly occur during acute HIV/SIV ...GCN2-ATF4 signaling and its role in HIV/SIV replication during chronic ...
16
Vesicular Stomatitis Virus M Protein Mutant Stimulates Maturation of Toll-Like Receptor 7 (TLR7)-Positive Dendritic Cells through TLR-Dependent and -Independent Mechanisms
... upregulating antiviral genes ...its signaling adaptor, MyD88, rwt virus failed to induce maturation of F-DC ...TLR7/MyD88 signaling by pDC is required for responsiveness to wt VSV, as well as another ...
14
The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling
... MAPK signaling, p38 MAPK and JNK, were also robustly activated upon infection with CHIKV both in HOS and in BHK-21 ...JNK signaling, which would not occur in the trans-replication ...
15