Apo-E
Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo
... bear apo B-100 and apo E bind to urate crystals and suppress crystal-neutrophil ...with apo E of monocyte origin, had a diminished ability to stimulate ...neutrophils. Apo ...
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Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles
... human apo CIII transgenic (HuCIIITg) mice were found to have elevated triglyceride ...of apo CIII (human and mouse) per VLDL particle was 2 and ...Mouse apo E was decreased by 35 and 77% in ...
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Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice
... a 129/J background and had been backcrossed six times to C57BL/6J mice (20). At 5–7 wk of age, male apo E KO mice were put on a “Western” diet (see below) and injected with ivIg or HSA as de- scribed in ...
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Apo E structure determines VLDL clearance and atherosclerosis risk in mice
... containing apo B-48 but not apo B-100, may be related to the differential interaction of VLDL particles with the hepatic ...clearing apo B-48–containing particles but less so in clearing apo ...
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Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man Apo B,E and apo E receptors
... the apo-E receptors were detected on th hepatic membranes of adult ...the apo-B,E receptors, as determined by canine LDL binding to the hepatic membranes, was found to be highly dependent on ...
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Disruption of the 12/15 lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
... an apo E–deficient background, indicating no gene dosage ...In apo E–deficient mice, lesions in the aortic sinus area are among the most prominent early sites of predilection (51); thus, ...
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Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice
... PSE mice also displayed significantly increased percent- age body fat, ~20% compared to ~15% in HFC mice. To date, there has been just one study reporting significant weight gain in apo-E-deficient mice ...
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Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice
... homozygous apo E-deficient mice were pur- chased from Jackson Laboratories (Charles River Labo- ratories, L’Arbresle, France) and interbred to obtain the males used for the present ...
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Substitution of the carboxyl terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout mice
... of apo E KO overex- pressing the different human apo AI variants were compared with that of HDL of apo E KO ...of apo E KO mice # HDL of des-(190-243)-apo ...
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Apo A I inhibits foam cell formation in apo E–deficient mice after monocyte adherence to endothelium
... human apo A-I transgene on the apo E–deficient background increases HDL cholesterol and greatly diminishes fatty streak lesion ...8-week-old apo E–deficient and apo ...
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MCP 1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B
... increased apo B production rates ...Human apo B transgenic mice (16, 17, 42) have significantly increased apo B production rates (17) but, unlike apo E–deficient mice, have relatively ...
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Prolonged postprandial responses of lipids and apolipoproteins in triglyceride rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele
... phatidylcholine, apo E4 and apo E3 have indistinguishable af- finity for the LDL receptor (4), but the affinity of spherical TRL bearing these forms of apo E is ...containing apo ...
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Synergistic effects of high fat feeding and apolipoprotein E deletion on enterocytic amyloid-beta abundance
... Apolipoprotein E critically regulates cholesterol metabo- lism and lipid ...The apo E protein is the pri- mary receptor ligand for dietary-derived lipoproteins synthesized by the small intestine ...
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Apolipoprotein gene polymorphisms and plasma levels in healthy Tunisians and patients with coronary artery disease
... the APO (a) gene have been described in the 5'-untranslated region ...the APO (a) gene (chro- mosome 6, 6q26-q27) may explain a part of the between- individual variability of lipoprotein Lp(a) ...[7,8]. ...
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Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis
... serum apo E, whereas they had significantly lower levels of LDL cho- lesterol and HDL cholesterol, as well as the serum concen- tration of apolipoproteins B-100 and A-1 (Table ...for apo E ...
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New mutants of apolipoprotein E associated with atherosclerotic diseases but not to type III hyperlipoproteinemia
... anti-apo E antibody. The most basic component of apo E-Suita (E-VII) was the unsialylated form and other components (E-VI and E-V), the sialylated ...that apo ...
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Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma
... increased apo E content on lipoproteins corre- lates positively with enhanced receptor binding and cellular uptake, with apo E having a 20-fold greater affinity for the LDL receptor than ...
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Changes of genetic apolipoprotein phenotypes caused by liver transplantation Implications for apolipoprotein synthesis
... of apo A-IV, apo E, and of the Lp(a) glycoprotein (apo (a] in the plasma of subjects undergoing liver transplantation and in respective organ ...plasma apo E and virtually all ...
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Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits
... human apo E or rabbit plasma apo ...of apo E resulted in an approximately 20-40% acute reduction in plasma cholesterol levels within 2-3 ...of apo E. Furthermore, the ...
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Tumor necrosis factor alpha modulates monocyte/macrophage apoprotein E gene expression
... monocyte/macrophage apo E ...of apo E mRNA ...inhibited apo E mRNA ...in apo E mRNA. This increase was reflected in apo E synthesis and was associated ...
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