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apoA-I

Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent

Gene transfer of wild-type apoA-I and apoA-I Milano reduce atherosclerosis to a similar extent

... LDL receptor deficient mice on C57BL/6 background (LDLR-/- mice) were purchased from the Jackson Labora- tory (Bar Harbor, ME, USA) and maintained as a breeding colony. Mice were given unrestricted access to water. Male ...

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Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes

Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes

... that apoA-I induces an increase in ABCA1 phosphorylation, as well as an increase in the intracellular levels of cAMP [19], sug- gesting that the stimulatory effect of apoA-I could be related ...

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Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA I

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA I

... lipid-free apoA-I with PL and FC in peripheral tissues would provide a source of nascent HDL particles, which, upon matura- tion to spherical HDL in plasma by LCAT and PLTP, would direct the flux of ...

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The Interaction of ApoA-I and ABCA1 Triggers Signal Transduction Pathways to Mediate Efflux of Cellular Lipids

The Interaction of ApoA-I and ABCA1 Triggers Signal Transduction Pathways to Mediate Efflux of Cellular Lipids

... enhance apoA-I- mediated cholesterol efflux, whereas ex- pression of a dominant negative Cdc42 impaired this efflux ...to apoA-I results in a cascade of signaling events, including activation of ...

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Statin induced inhibition of the Rho signaling pathway activates PPARα and induces HDL apoA I

Statin induced inhibition of the Rho signaling pathway activates PPARα and induces HDL apoA I

... and apoA-I plasma levels, the first goal of this study was to determine the molec- ular mechanism leading to increased apoA-I production under HMG-CoA reductase ...human apoA-I ...

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Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA I production

Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA I production

... of ApoA-I production in the medium from hepatocytes treated with etomoxir, another mem- ber of the CPT1 inhibitor group (56), suggesting the effect of perhexiline on ApoA-I expression is not ...

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ApoA-I/A-II-HDL positively associates with apoB-lipoproteins as a potential atherogenic indicator

ApoA-I/A-II-HDL positively associates with apoB-lipoproteins as a potential atherogenic indicator

... 4 apoA-I molecules and determine total plasma HDL ...two apoA-I and one disulfide-dimeric apoA-II molecules and little-variable plasma concentration regardless of total HDL ...

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A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA I

A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA I

... While our studies were ongoing, Arakawa and Yokoyama reported the apolipoprotein stabilization of ABCA1 in cell culture (19), and our major findings are consistent with and complementary to theirs. Our study was ...

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Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study

Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study

... of apoA-I on improving insulin sensitivity have been further inves- tigated in human skeletal muscle cells and adipocytes, in which both HDL-C and apoA-I promoted glucose uptake independently ...

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The unsolved mystery of apoA-I recycling in adipocyte

The unsolved mystery of apoA-I recycling in adipocyte

... both apoA-I internalization and adipocyte lipolysis are stimulated by PKA ...of apoA-I in intracellular cholesterol transport during lipid mobilization may ...onto apoA-I was ...

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An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration

An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration

... Lecithin cholesterol acyltransferase (LCAT) plays a key role in the reverse cholesterol transport (RCT) process by converting cholesterol to cholesteryl ester to form mature HDL particles, which in turn deliver ...

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Identification of serum proteins AHSG, FGA and APOA-I as diagnostic biomarkers for gastric cancer

Identification of serum proteins AHSG, FGA and APOA-I as diagnostic biomarkers for gastric cancer

... and APOA-I) were validated in a larger cohort with high diagnostic accuracies, which sug- gested that FGA, AHSG and APOA-I might be developed as potential diagnostic ...

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Human ApoA II inhibits the hydrolysis of HDL triglyceride and the decrease of HDL size induced by hypertriglyceridemia and cholesteryl ester transfer protein in transgenic mice

Human ApoA II inhibits the hydrolysis of HDL triglyceride and the decrease of HDL size induced by hypertriglyceridemia and cholesteryl ester transfer protein in transgenic mice

... the apoA-II/apoA-I ratio of HDL. The presence of human apoA-II also inhibited mouse plasma hepatic lipase activity on HDL ...Thus, apoA-II does not inhibit the lipid transfer activity ...

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Human Intestinal Lipoproteins: STUDIES IN CHYLURIC SUBJECTS

Human Intestinal Lipoproteins: STUDIES IN CHYLURIC SUBJECTS

... of apoA-II in chylous urine was in the d < ...of apoA-I and apoA-II excreted on triglyceride-rich lipoproteins revealed that for these lipid loads, intestinal secretion could account for 50 ...

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Tangier Disease: HIGH DENSITY LIPOPROTEIN DEFICIENCY DUE TO DEFECTIVE METABOLISM OF AN ABNORMAL APOLIPOPROTEIN A I (APOA ITANGIER)

Tangier Disease: HIGH DENSITY LIPOPROTEIN DEFICIENCY DUE TO DEFECTIVE METABOLISM OF AN ABNORMAL APOLIPOPROTEIN A I (APOA ITANGIER)

... Tangier disease is a rare familial disorder characterized by enlarged orange tonsils, transient peripheral neuropathy, hepatosplenomegaly, and lymphadenopathy, as well as striking reductions in plasma high density ...

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Decreased pretherapy serum apolipoprotein A-I is associated with extent of metastasis and poor prognosis of non-small-cell lung cancer

Decreased pretherapy serum apolipoprotein A-I is associated with extent of metastasis and poor prognosis of non-small-cell lung cancer

... serum ApoA-I was measured by turbidimetric ...serum ApoA-I levels with the clinico- pathologic characteristics and clinical outcomes of NSCLC patients was ...serum ApoA-I levels. ...

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The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit

The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit

... cholesterol for 6-weeks. The animals received two infusions of saline, rHDL (8 mg/kg apoA-I) or ETC-642 (30 mg/kg peptide) on the third and fifth days of the final week. The infusions of rHDL and ETC-642 ...

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Rapid in vivo transport and catabolism of human apolipoprotein A IV 1 and slower catabolism of the apoA IV 2 isoprotein

Rapid in vivo transport and catabolism of human apolipoprotein A IV 1 and slower catabolism of the apoA IV 2 isoprotein

... to apoA-I, the major apolipoprotein in high density lipoproteins ...(HDL). ApoA-IV plays a potentially important role in lipoprotein metabolism and reverse cholesterol transport, but its in vivo ...

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Regulation and mechanisms of macrophage cholesterol efflux

Regulation and mechanisms of macrophage cholesterol efflux

... border region between liquid and cholesterol-rich liq- uid–ordered membrane microdomains. Thus, al- though phospholipid and cholesterol efflux are nor- mally coupled, this model (Figure 3b) predicts that the two ...

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Apolipoprotein A I Q[ 2]X causing isolated apolipoprotein A I deficiency in a family with analphalipoproteinemia

Apolipoprotein A I Q[ 2]X causing isolated apolipoprotein A I deficiency in a family with analphalipoproteinemia

... approximately half-normal apoA-I and HDL. Gradient gel electrophoresis and differential electroimmunodiffusion assay revealed that the HDL particles of the homozygotes had peak Stokes diameter of 7.9 nm and ...

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