APOE gene
Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population
... the gene, for example, when the 112th and 158th positions are all cysteines, the allele is E2; when both loci are arginine, the allele is E4; when 112th is arginine and 158th is cysteine, the allele is ...in ...
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Low Ankle Brachial Index in Acute Ischemic Stroke: Does ApoE Gene Polymorphism Have a Role?
... of ApoE gene on acute ischemic stroke presentation in patients with low ABI is not ...of ApoE gene polymorphism on stroke severity, outcome and recurrence in patients with asymptomatic ...
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Original Article Correlation analysis between APOE gene polymorphism and Alzheimer’s disease
... between APOE gene polymorphism (SNP) and ...the APOE gene polymorphism was analyzed by restriction fragment length polymorphism polymerase chain reaction (PCR-RFLP) and Sanger ...different ...
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The Changing Regulation of Autophagy in Atherosclerosis in ApoE Gene Knockout Mice
... Recent studies suggest that autophagy plays an important role in the formation and development of AS. Such as, Verheye et al [18] found autophagy presents in the macrophages and smooth muscle cells in AS plaques by using ...
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Impact of APOE gene polymorphisms on the lipid profile in an Algerian population
... the APOE epsilon polymorphism and plasma lipid levels in North African ...the APOE ε4 allele is associated with higher plasma concentrations of total cholesterol and LDL-cholesterol, whereas the APOE ...
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Apolipoprotein E gene polymorphisms and migraine
... each APOE-specific primer mix also contained a pair of "control primers" (primers 8 and 9), which amplified two regions of chromo- some 6 in the HLA-DR locus, to verify PCR amplifica- tion in the absence ...
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A novel apolipoprotein E mutation caused by a five amino acid deletion in a Chinese family with lipoprotein glomerulopathy: a case report
... the apoE gene. More than 10 variants of apoE associated with LPG have currently been ...of apoE were amplified by polymerase chain reaction ...the apoE gene that results in a ...
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Association of Apolipoprotein E Gene Polymorphism with Lipid Profile in Patients with Acute Coronary Syndrome in Han Chinese: A Critical Review
... polymorphic gene on lipid profile and ApoE gene affecting the effect of Statin in just a small sample size se- ...of ApoE on lipid ...that ApoE genotype polymorphism would affect the ...
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Pharmacogenetics of lipid diseases
... Individuals who respond better to one type of recom- mendation than to another can now begin to be characterised. For example, a low fat, low cholesterol strategy may be especially beneficial in terms of lowering plasma ...
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Identification of Genetic Polymorphism Interactions in Sporadic Alzheimer’s Disease Using Logic Regression
... the APOE on chromosome 19. This gene has been identified as the most important risk factor in 65% of sporadic Alzheimer cases ...The APOE gene in human has the three allele e2, e3, ...
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The APOE E4 Allele Confers Increased Risk of Ischemic Stroke Among Greek Carriers
... several gene polymorphisms and how they might influence the risk of stroke, and ma- ny candidate genes have been analyzed in this ...common gene polymorphisms and isch- emic stroke ...(APOE) ...
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Apolipoprotein E gene polymorphism and the risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies
... The APOE gene polymorphisms are associated with many other ...that APOE ε 4 allele appeared to be associated with a higher prevalence of dementia in Parkinson disease ...the APOE ε 4 isoform ...
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BLMH and APOE genes in Alzheimer Disease: A possible relation
... E gene (APOE) is associated with AD and it is the main genetic risk factor for ...the APOE gene and BLMH 1450 G > A polymorphism and assess BLMH expression using PCR-RFLP and RT-qPCR ...
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Apolipoprotein E ε4 allele modulates the immediate impact of acute exercise on prefrontal function
... the ApoE gene triggers different pathways of neural ...the ApoE gene may have an impact on neural plasticity and may influence the effectiveness of an intervention designed to regulate brain ...
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Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors
... The APOE gene is located on chromosome ...the APOE mRNA which is 1180 nucleotides long. The seven tagSNPs for the APOE gene were chosen based on Inter- national HapMap Phase II ...
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A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism
... APOE genotyping assay development and validation Our assay was based on allele-specific PCR methodology adapted to Real Time PCR monitored by TaqMan probe. Initial PCR primers were designed according to the nu- ...
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Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice
... different APOE alleles extends well beyond diseases thought to involve Aβ pep- tide-mediated neurotoxicity, as noted ...other apoE-isoform specific mechanisms likely exist to explain the apparent influence ...
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Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2
... mouse Apoe gene with the human APOE*2 allele was performed in mouse embryonic stem cells using the same strategy as previously de- scribed (10), except that the targeting construct contained exons ...
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Phenotype dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte derived macrophages
... in apoE mRNA tran- scription and protein secretion after macrophage loading are paralleled by differences in cholesterol and cholesteryl ester accumulation ...in apoE synthesis and se- cretion as well as in ...
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Gene dose of apolipoprotein E and age-related hearing loss
... Biffi, A., Sonni, A., Anderson, C.D., Kissela, B., Jagiella, J.M., Schmidt, H., Jimenez-Conde, J., Hansen, B.M., Fernandez-Cadenas, I., Cortel- lini, L., Ayres, A., Schwab, K., Juchniewicz, K., Urbanik, A., Rost, N.S., ...
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