ApoE genotype
Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
... that APOE genotype has a profound impact on the molecular fingerprint of the synapse and that further understanding of the effects of these protein changes may contribute to our understanding of, and ul- ...
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Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation
... cause APOE , APOC1 , and disease state each varied, and important potential confounders like post mortem inter- val and agonal state were not ...with APOE geno- ...of APOE E4 (774 ± 41 ng/mL) com- ...
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APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice
... various APOE genotypes [40 – ...of apoE within CAA lesions is critical for formation of Aβ fibrillar assemblies ...that APOE genotype modulates development of both CAA and CCA pathology in APP ...
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The association of APOE genotype and cognitive decline in interaction with risk factors in a 65–69 year old community sample
... whether APOE *E4 carrier status is associated with more rapid cognitive decline in the general population when those with either dementia or preclinical dementia are ...of APOE genotype ...of ...
10
Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease
... APOE genotype. Finally, we aimed to study the relationship between APOE and MRS metabolites in different stages of predementia ...healthy APOE e4 carriers with still nor- mal CSF Ab42 levels ...
10
APOE genotype and cognitive change in young, middle-aged, and older adults living in the community.
... six APOE genotypes and age in relation to the cognitive measures over time (N = ...the APOE ɛ2 and ɛ4 alleles, individuals possessing the ɛ2/4 genotype were removed (n = 140) and individuals with ...
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The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease
... human APOE replacement mice demonstrated reduced delivery of 14 C -labeled DHA to the brain in the ɛ4 compared with the ɛ3 and ɛ2 human replacement mice ...of APOE genotype on CSF delivery of DHA was ...
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Long-chain omega3 polyunsaturated fatty acids and cognition in older people: interaction with APOE genotype
... of APOE genotype on LC n-3 PUFA metabolism and its relation to cognitive decline in older ...and APOE genotype on ...APOE4 genotype modifies the metabolism of DHA. The APOE ...
5
APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice
... ( APOE ) genotype and sex, two well-established AD risk factors that modulate microglial ...APOE4 genotype and female ...APOE4 genotype and female sex were associated with significantly lower ...
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Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype
... one APOE ε2 allele is protective against Aβ plaque deposition is consistent with previous reports associating this genotype with protection against Alzheimer’s disease ...in APOE ε3,3 carriers ...
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Variability in APOE genotype status in human-derived cell lines: a cause for concern in cell culture studies?
... the APOE genotype status by research groups working with human-derived cell ...their APOE genotype might vary with each new ...particular APOE genotype, but on the pre- sence and ...
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Midlife insulin resistance, APOE genotype, and late-life brain amyloid accumulation
... The findings presented here are also in accord with the Ath- erosclerosis Risk in Communities (ARIC) study, which showed that midlife, but not late-life, vascular risk factors increase the risk of an amyloid-positive PET ...
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APOE genotype and stress response - a mini review
... of APOE ε4 may be deleterious to the organism with advanced age, it may confer greater protection from pathogens early in life (“antagonistic pleiotropy” theory, ...of APOE ε4 is still observed in certain ...
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Apolipoprotein E genotype affects tissue metallothionein levels: studies in targeted gene replacement mice
... APOE4 affects both morbidity and mortality in humans (Mahley et al. 2009; Jofre-Monseny et al. 2008b). A dys- regulation in MT homoeodynamics may adversely affect age-related chronic diseases (Swindell 2011). Here, we ...
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CSF level of β-amyloid peptide predicts mortality in Alzheimer’s disease
... between APOE genotype and tau bio- markers on mortality outcomes in AD ...biomarkers, APOE genotype, and age were not associated with risk of ...
9
Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial
... Finally, Table 5 displays the effects of the MedDiet intervention on cognition (MMSE and CDT) in our popu- lation according to the ApoE genotype. In the first general analysis, the linear regression model ...
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Original Article Association of apolipoprotein E with the progression of hepatitis B virus-related liver disease
... in ApoE gene could affect dis- ease progression in HBV infected ...the ApoE genotype distribution in healthy volunteers, inactive HBV carriers, and patients with acute hepatitis, chronic hep- atitis, ...
8
Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's Disease: a cross-sectional study
... The primary contrast used to evaluate group differences was novel versus familiar pictures. For completeness, we also examined group differences in activation for the familiar versus novel contrast. All single-subject ...
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Genotype-Environment Interaction: Apolipoprotein E (ApoE) Gene Effects and Age as an Index of Time and Spatial Context in the Human
... across age windows of each genetic architecture parameter estimate on each ApoE genotype relative frequency and the squared deviation of each genotype plasma ApoE [r] ...
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Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?
... available, this analysis cannot be performed. This would have given complementary information regarding FA profiles, especially with regards to the level of each TRL according to APOE genotype. This study ...
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