Apolipoprotein A-I
Synthetic amphipathic helical peptides that mimic apolipoprotein A I in clearing cellular cholesterol
... cholesterol and phospholipid efflux from cells and depleted cellular cholesterol accessible for esterification by acyl CoA/cholesterol acyltransferase, similar to what was observed for purified apolipoprotein ...
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ASSOCIATION OF CAROTID INTIMA-MEDIA THICKNESS WITH LEPTIN AND APOLIPOPROTEIN B/APOLIPOPROTEIN A-I RATIO REVEALS IMMINENT PREDICTORS OF SUBCLINICAL ATHEROSCLEROSIS IN PSORIASIS PATIENTS
... and apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I ratio) in relation with CIMT of carotid ...and apolipoprotein were measured using enzyme-linked immuno sorbent assay (ELISA) ...
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Preoperative serum apolipoprotein A-I levels predict long-term survival in non-muscle-invasive bladder cancer patients
... a-i, apolipoprotein a-i; apo B, apolipoprotein B; BMi, body mass index; Cis, carcinoma in situ; Css, cancer-specific survival; GLB, globulin; HDL, high-density lipoprotein–cholesterol; hg, ...
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Serum prostacyclin stabilizing factor is identical to apolipoprotein A I (Apo A I) A novel function of Apo A I
... human apolipoprotein A-I (Apo A-I), a major apolipoprotein of ...HDL. Apolipoprotein A-II, C-I, C-II, C-III, D and E, as well as LDL, and VLDL did not possess this ...
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Inhibition of HIV Replication by Apolipoprotein A I Binding Protein Targeting the Lipid Rafts
... ABSTRACT Apolipoprotein A-I binding protein (AIBP) is a protein involved in regu- lation of lipid rafts and cholesterol efflux. AIBP has been suggested to function as a protective factor under several sets ...
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<p>Serum Apolipoprotein A-I Combined With C-Reactive Protein Serves As A Novel Prognostic Stratification System For Colorectal Cancer</p>
... Lipids are composed of fats (triglyceride, TG) and lipids (phospholipid, cholesterol and cholesterol ester). Lipid metabolism involves the process of lipid synthesis, storage and degradation. 5 Abnormal lipid metabolism ...
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The Measurement of Apolipoprotein A I and A II Levels in Men and Women by Immunoassay
... apolipoprotein A-I (A-I) (r = 0.71) and high density lipoprotein (HDL) cholesterol (men, r = 0.64; women, r = 0.49). The A-I/A-II ratio was significantly related to HDL cholesterol (men, r = ...
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Comparative in vitro study of the pro apolipoprotein A I to apolipoprotein A I converting activity between normal and Tangier plasma
... We examined the ability of the plasma of a 52-yr-old male Tangier patient to effect the conversion of radiolabeled pro-apolipoprotein A-I (apo A-I), isolated from hepatoma cell culture media, into ...
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Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes
... [34]. According to an earlier report, ER stress was asso- ciated with hepatic SREBP1c activation [4]. A recent study of TM-treated mice found that ER stress can lead to a dramatic conversion of the precursors of SREBP1c ...
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β<sub>3</sub>-Adrenoceptor activation upregulates apolipoprotein A-I expression in HepG2 cells, which might further promote cholesterol efflux from macrophage foam cells
... from Amersham (Arlington Heights, IL, USA). Antibodies against ApoA-I, ApoA-II, ApoB, β 3 -AR, PPAR γ , PPAR α , ABCA1, ABCG1, and GAPDH were purchased from Abcam (Cambridge, MA, USA). Goat antirabbit and ...
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<p>Characterization of apolipoprotein A-I peptide phospholipid interaction and its effect on HDL nanodisc assembly</p>
... particles (Figure 1A). 5–7 Following intravenous administra- tion, sHDL nanoparticles uptake cholesterol from peripheral tissues and interact with endogenous lipoproteins in plasma by exchanging lipid and protein ...
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Assessment of apolipoprotein B/apolipoprotein A-I ratio in non-ST segment elevation acute coronary syndrome patients
... The results of the current study have their assumed clinical implications. High apoB/apoA-I ratio (≥ 0.82) re- corded before coronary angiography in NSTE-ACS pa- tients calls for proper readiness (pharmacological ...
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Distinct serum apolipoprotein A-I levels in neuromyelitis optica and acute transverse myelitis
... All statistical analyses were performed using the Statis- tical Program for Social Sciences (SPSS) statistical soft- ware (version 11.0, Chicago, IL, USA). All the data in this study were presented as means ± SD. ...
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A role for apolipoprotein E, apolipoprotein A I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve
... associations of apoE, apoA-I, and the LDL receptor during nerve repair and to determine the distribution of lipid at each stage. After a crush injury, as axons died and Schwann cells reabsorbed myelin, resident ...
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Role of thyroid hormones in apolipoprotein A I gene expression in rat liver
... triiodothyronine into euthyroid rats, apo A-I gene transcription increased at 20 min, reached a maximum of 179% of control (P less than 0.01) at 3.5 h, and remained elevated for up to 48 h. The abundance of ...
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Defective removal of cellular cholesterol and phospholipids by apolipoprotein A I in Tangier Disease
... desorption of radiolabeled cholesterol or phospholipids into medium containing albumin or trypsinized HDL was normal for Tangier cells. Binding studies showed that the interaction of apo A-I with high-affinity ...
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Association between LDL, Apolipoprotein B Apolipoprotein A I and Lipoprotein(a) and Severity of Coronary Artery Disease Based on Coronary Angiography
... The relationship between lipoprotein levels and the degree of coronary atherosclerosis is less consistent and depends on the method of assessment on patient. Sullivan et al. [7] has introduced an angiographic score to ...
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Apolipoprotein A I Q[ 2]X causing isolated apolipoprotein A I deficiency in a family with analphalipoproteinemia
... We report a Canadian kindred with a novel mutation in the apolipoprotein (apo) A-I gene causing analphalipoproteinemia. The 34-yr-old proband, product of a consanguineous marriage, had bilateral ...
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Apolipoprotein A-I and A-I mimetic peptides: a role in atherosclerosis
... Although much attention has been devoted to the role of HDL and apoA-I in mediating reverse cholesterol transport, it is now becoming more widely recognized that HDL has other functions that could potentially ...
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Opposite regulation of human versus mouse apolipoprotein A I by fibrates in human apolipoprotein A I transgenic mice
... In addition to their effects on apo A-I gene transcription, different fibrates may elicit different metabolic responses. In- deed, both in rodents (65, 66) as well as in humans (28, 29), gemfibrozil has been shown ...
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