Apolipoprotein E and B
Original Article Association of apolipoprotein E with the progression of hepatitis B virus-related liver disease
... Hepatitis B virus (HBV) infection increases the risk of liver decompensation, cirrhosis and hepatocellular carcinoma ...(HCC). Apolipoprotein E (ApoE), one of the major cholesterol carriers, plays ...
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Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation
... Apolipoprotein (apo) E and the two B apolipoproteins, apoB48 and apoB100, are important proteins in human lipoprotein metabolism. Commonly occurring polymorphisms in the genes for apoE and apoB ...
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Apolipoprotein E, but Not Apolipoprotein B, Is Essential for Efficient Cell-to-Cell Transmission of Hepatitis C Virus
... ApoE expression in donor cells is a determinant for HCV cell-to-cell transmission. To study whether the role of ApoE in HCV cell-to-cell spread is restricted to HCV exit of producing cells or viral entry into acceptor ...
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Apolipoprotein E but Not B Is Required for the Formation of Infectious Hepatitis C Virus Particles
... FIG. 3. Effects of siRNA-mediated knockdown of apoB and apoE expression on HCV replication and production. Huh7.5 cells were infected with HCV at an MOI of 5 and then transfected with apoB, apoE, or NSC siRNA as ...
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Regulation of Hepatic Lipoprotein Receptors in the Dog RAPID REGULATION OF APOLIPOPROTEIN B,E RECEPTORS, BUT NOT OF APOLIPOPROTEIN E RECEPTORS, BY INTESTINAL LIPOPROTEINS AND BILE ACIDS
... Two distinct lipoprotein receptors can be expressed in the dog liver. One is the apolipoprotein (apo-) B,E receptor. This receptor binds apo-B-containing low density lipoproteins (LDL), as ...
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Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E Accelerated clearance of lipoproteins containing apolipoprotein B
... apo E facilitates metabolism of lipoproteins containing apo B presumably primarily via the LDL receptor pathway and possibly through an interaction with the chylomicron remnant ...
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The Influence of Apolipoprotein E Polymorphism on Plasma Concentrations of Apolipoprotein B and A-I During the First Year of Life
... A, Apolipoprotein (apo)B and apoA-I plasma concentrations in newborns (7 days, n = 199) relative to their apoE phenotype.. Significant to apoE phenotype 3/3.[r] ...
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Influence of apolipoprotein E polymorphism on apolipoprotein B 100 metabolism in normolipemic subjects
... apo B was followed through intermediate density lipoprotein (IDL) to low density lipoprotein ...apo B was directed to LDL ...apo B to LDL than E3 subjects. About 70% of VLDL2 apo B was found ...
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Chylomicronemia due to apolipoprotein CIII overexpression in apolipoprotein E null mice Apolipoprotein CIII induced hypertriglyceridemia is not mediated by effects on apolipoprotein E
... Lipoprotein analysis. Triglyceride and cholesterol concentra- tions were performed using commercial kits (Boehringer Mannheim Biochemicals, Indianapolis, IN) on an autoanalyzer (model 705; Hita- chi Ltd., Tokyo, Japan). ...
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Analysis of apolipoprotein E genetic variation in patients with Alzheimer disease referred to Imam Reza Clinic, Rasht, Iran, in 2015
... 16. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A ...
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Apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins modulate adipocyte triglyceride content
... contain apolipoprotein B48 particles, whereas all VLDL from humans contain apolipoprotein B100 par- ticles ...[54]. Apolipoprotein B48 is a truncated form of apolipoprotein B, which ...
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Inhibition of platelet aggregation by apolipoprotein E
... “prim e” platelets to help attenuate eN O S activation when challenged by agonists or other ...cascade. B oth these events could be localised in caveolae-like domains at the platelet surface, which are ...
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THE PROTEOLYSIS OF APOLIPOPROTEIN E IN ALZHEIMER’S DISEASE
... In a final set of experiments, we examined whether nApoECFp17 labeling occurs together with MMP-9, an extracellular protease that was able to generate the predicted ~17 kDa fragment in vitro (Fig. 3C). As an initial ...
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Apolipoprotein E in diabetic dyslipidemia and atherosclerosis
... VLDL fractionated from plasma by sequential ultracentrifugation had a similar composition of cholesterol, triglycerides, and phospholipids (Figure 2.3A). Diabetes induced a 5 and 26% increase in apoB100 and a 10 and 57% ...
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LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL
... apoA-I: apolipoprotein A-I; apoB: apolipoprotein B; apoE: apolipoprotein E; TO: TO901317; M-Hep: HepG2 cells cultured in monolayer; S-Hep: HepG2 cells cultured in spheroidal form; HNF: h[r] ...
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The emerging role of apolipoprotein C-III: beyond effects on triglyceride metabolism
... apoB: apolipoprotein B; apoCIII: apolipoprotein C-III; apoE: apolipoprotein E; ASO: Antisense oligonucleotide; CKD: Chronic kidney disease; CM: Chylomicron; CVD: Cardiovascular disease; ...
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Macrophage specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E null mice
... macrophages. Human apoE was secreted by peritoneal macrophages and was detected in Kupffer cells of the liver. Human apoE in the plasma of apoE-/-,hTgE+/0 mice (n = 30) was inversely correlated (P < 0.005) with the ...
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Immunoreactive apolipoprotein E is a widely distributed cellular protein Immunohistochemical localization of apolipoprotein E in baboon tissues
... In the 11 tissues studied, the following cell types have been found to harbor apoE immunoreactivity: cerebral astrocytes; thyroid follicular cells; alveolar type II pneumocytes; hepatocy[r] ...
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Radioimmunoassay studies of human apolipoprotein E
... This report describes the development and first applications of a sensitive and specific double antibody radioimmunoassay for human apoplipoprotein E (apoE). ApoE was purified from the very low density ...
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APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism
... Based on the findings mentioned above, we can specu- late that a relationship exists between HCV infection and lipid metabolism disorders through SNPs of APOB- 100, whereby the AA genotype (minor allele homozy- gote) of ...
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