apolipoprotein E deficient
Renal denervation promotes atherosclerosis in hypertensive apolipoprotein e-deficient mice infused with angiotensin II
... FIGURE 5 | RDN did not affect aortic rupture and the severity of the aortic aneurysm in the apolipoprotein E-deficient mice infused with angiotensin II. (A) Mice in the sham surgery and RDN groups ...
9
Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice
... apolipoprotein E-deficient (Apoe –/– ) mice sensitized with ovalbumin (OVA) together with aluminum, followed by OVA nebulization three times a ...
22
The Concurrence of Hypercholesterolemia and Aging Promotes DNA Damage in Apolipoprotein E Deficient Mice
... In the present study, we used the comet assay to evaluate the influence of aging on DNA damage in whole blood cells from apolipoprotein E-deficient apoE−/− mice and compared the results [r] ...
5
Protective effect of sildenafil on the genotoxicity and cytotoxicity in apolipoprotein E-deficient mice bone marrow cells
... The experiments were performed in 9-week-old male wild-type C57BL/6 (WT, n = 8) and apolipoprotein E- deficient (apoE −/− ) mice. The animals were bred and maintained in the animal care facility at ...
7
Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice
... hypercholesterolemic apolipoprotein E-deficient mice (ApoE, n = 13) and age-matched C57BL/6 control mice (C57, n = 15) were studied at 2 (young) and 8 (adult) ...
7
Coenzyme Q10 protects against hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice
... puzzling. Apolipoprotein E-deficient (ApoE −/− ) mice have been widely used as models of atherosclerosis because they can develop hyper- lipidemia and atherosclerotic lesions similar to those found ...
8
Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: a systematic review and meta-analysis
... Diets rich in flavonoids have been reported to have beneficial effects in the primary preven- tion of cardiovascular events. There are limited data, however, on the cardiovascular bene- fits of purified flavonoids. The ...
13
Endogenous female sex hormones delay the development of renal dysfunction in apolipoprotein E-deficient mice
... Experimentally, atherosclerosis can be induced by the inactivation of the apolipoprotein-E (apoE) gene by homologous recombination [4,5]. Among the genetically engineered models, the apoE-deficient ...
9
Absence of Interferon Regulatory Factor 1 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice
... Although the association between Myd88 and IRF1 clearly led to IRF1 translocation from cytoplasm to nucleus, Myd88 itself remained in cytoplasm and had not been recruited to SR-AI promoter in response to LPS stimulation ...
16
Impaired secretion of very low density lipoprotein triglycerides by apolipoprotein E deficient mouse hepatocytes
... Production of VLDL by the liver is an important determinant of plasma lipid levels in humans. It is well-established that apo B is required for the assembly and secretion of these TG-rich lipoproteins by liver cells, and ...
9
Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E-deficient mouse hepatocytes
... apo E may also have a function in the assembly and/or secretion of VLDL by the ...apo E synthesis and secretion by promoting transcription of the apo E ...apo E is present in nascent VLDL ...
9
Original Article Acetylshikonin suppresses atherogenesis by attenuating vascular inflammation in apolipoprotein E-deficient mice
... Schmid E, Mun- zer P, Voelkl J, Alesutan I, Rodriguez JM, Vogel S, Schoenberger T, Metzger K, Rath D, Umbach A, Kuhl D, Muller, II, Seizer P, Geisler T, Gawaz M and Lang ...
9
Original Article Sarpogrelate and rosuvastatin synergistically ameliorate hyperlipidemia-inducedcardiacdamage in apolipoprotein E-deficient mice
... Therefore, this study investigated the effects of SP plus rosuvastatin compared to rosuvastatin alone on cardiac damage in ApoE-/- mice with hyperlipidemia.. Male ApoE-/- mice were rando[r] ...
9
Mononuclear cell therapy reverts cuff-induced thrombosis in apolipoprotein E-deficient mice
... Figure 5 Representative images of the results of the TUNEL assay showing that the mononuclear cell (MNC) therapy markedly reduces the process of apoptosis (green fluorescent cells) in th[r] ...
10
Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse
... mice fed a normal diet, the cardiac weight has been reported as normal at different ages in several studies [42,46,61,83,85], but others have observed myocardial hypertrophy in adult [46] and aged [80,85] animals. ...
9
Endothelial Dysfunction in the Apolipoprotein E-deficient Mouse: insights into the influence of diet, gender and aging
... antiatherogenic apolipoprotein E (apoE) gene that is involved in cholesterol metabolism ...poprotein E-deficient (apoE -/- ) or knockout (apoE KO) ...
18
PEP 1 MsrA ameliorates inflammation and reduces atherosclerosis in apolipoprotein E deficient mice
... The goal of this study is to investigate whether the fusion protein PEP-1-MsrA can efficiently enter cells to protect against oxidative stress and to attenuate atherosclerosis in apolipo[r] ...
13
Endothelial dysfunction of resistance vessels in female apolipoprotein E-deficient mice
... Contrasting with males [12,13], we observed that female ApoE-deficient mice on a normal chow diet show endothelial dysfunction of resistance vessels. Similar results have been observed by others in the aorta and ...
5
Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E deficient mice
... probucol occurs throughout the aortic tree of apoE mice. Lesions in probucol-fed mice are more mature than those in control mice. Histological examination was carried out by light microscope of the serial sections of ...
10
CD6 expression has no effect on atherosclerosis in apolipoprotein E deficient mice
... Results: We compared cholesterol levels, IgM, B1a cells, and aortic root lesion areas in ApoE‑deficient vs. CD6/ApoE double deficient mice. Feeding the high‑fat western type diet increased all parameters, ...
5