apolipoprotein E–deficient mice
Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice
... hypercholesterolemic apolipoprotein E-deficient mice (ApoE, n = 13) and age-matched C57BL/6 control mice (C57, n = 15) were studied at 2 (young) and 8 (adult) ...
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Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: a systematic review and meta-analysis
... protein E deficient ...208 mice receiving a flavonoid and 126 control mice, were ...in apolipoprotein E deficient ...
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Original Article Sarpogrelate and rosuvastatin synergistically ameliorate hyperlipidemia-inducedcardiacdamage in apolipoprotein E-deficient mice
... LOX-1 and LDL receptor (LDL-r) gene expression significantly increased in the hearts of mice in the H group, compared to that in the control group. How- ever, this increase in LOX-1 and LDL-r expression was ...
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Endogenous female sex hormones delay the development of renal dysfunction in apolipoprotein E-deficient mice
... Another important effect of estrogen relies on renal nitric oxide (NO) synthesis and/or bioavailability. The NO system consists of three distinct NO synthase (NOS) isoforms, encoded by three distinct genes, includ- ing ...
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Coenzyme Q10 protects against hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice
... Cardiac damage induced by hyperlipidemia is usually associated with an increase in the number of macro- phages. Macrophage-derived foam cells release cytokines that recruit more macrophages to lesions and influence lipid ...
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Protective effect of sildenafil on the genotoxicity and cytotoxicity in apolipoprotein E-deficient mice bone marrow cells
... In the present study, the micronucleus test was per- formed on bone marrow samples to investigate the pro- tective effects of sildenafil on the DNA of apoE − / − mice. Figure 4a shows typical images of PCE, NCE ...
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Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E deficient mice
... apoE mice. Lesions in probucol-fed mice are more mature than those in control ...nontreated mice (Fig. 4 A), the lesions in mice treated with probucol for 3 mo ...nontreated mice were ...
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Original Article Acetylshikonin suppresses atherogenesis by attenuating vascular inflammation in apolipoprotein E-deficient mice
... HFD-fed mice than in HFD-fed mice alone. Moreover, AS-treated mice revealed remarkably lower ab- undance of Ly-6G-positive neutrophils (Figure ...HFD-fed mice than in HFD-fed mice, ...
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Absence of Interferon Regulatory Factor 1 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice
... phage rich. To determine whether IRF1 affects foam cell formation, Oil Red O staining and quantification of cholesterol content were performed in primary peritoneal macrophages isolated from mice. As shown in ...
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Renal denervation promotes atherosclerosis in hypertensive apolipoprotein e-deficient mice infused with angiotensin II
... Bilateral RDN was carried out as previously described (O’Neill et al., 1991; Ye et al., 1997). In brief, after the renal arteries and veins were exposed, all visible nerves around the renal arteries were cut, and ...
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Lipingshu capsule improves atherosclerosis associated with lipid regulation and inflammation inhibition in apolipoprotein E–deficient mice
... wild-type mice were fed a low fat diet (10 kcal% fat, 0% cholesterol, Research Diets D12102C, USA) and assigned as control group (CON, n = ...−/− mice were fed high fat rodent diet (40 kcal% fat, ...whose ...
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Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy
... Apolipoprotein E (ApoE) is a multifunctional protein known to reduce circulating oxidized low-density lipo- proteins and atherogenesis in the vessel wall ...knockout mice have increased oxidized ...
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Adiponectin improves NF-κB-mediated inflammation and abates atherosclerosis progression in apolipoprotein E-deficient mice
... Lipid accumulation causes dysregulation of adipokine production, which makes a strong contribution to the onset of inflammation and atherosclerosis [24]. The atherogenic process is initiated by the formation of oxi- ...
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Original Article Genistein alleviates atherosclerosis in apolipoprotein E-deficient mice by interrupting the OX40/OX40L pathway
... anti-cancer as well as anti-inflammatory effects [7, 8]. It also possesses cardioprotective eff- ects, such as improving isoprenaline-induced cardiac hypertrophy and pressure overload (PO)- induced cardiac fibrosis [9, ...
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Angiopoietin-2 attenuates angiotensin II-induced aortic aneurysm and atherosclerosis in apolipoprotein E-deficient mice
... Two mice in the control group and one mouse in the rAngpt2 group died during the experimental period of non-aneurysm related causes and were excluded from the ...control mice (17%) at days 5, 6, 12 and 13. ...
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Treatment of severe hypercholesterolemia in apolipoprotein E deficient mice by bone marrow transplantation
... apo E-deficient mice with either syngeneic apo E-deficient mouse bone marrow cells (E0-control) or wild-type mouse bone marrow cells expressing apo E ...E0-treated mice ...
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Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice
... hypertensive mice that overproduce Ang II, although only when mice were placed on high sodium chloride containing water ...Tsukuba mice during salt loading occurred independent of changes in arterial ...
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Mononuclear cell therapy reverts cuff-induced thrombosis in apolipoprotein E-deficient mice
... Figure 6 Localization of endothelial progenitor cells (EPC) and green fluorescent protein (GFP)-derived mononuclear cells (MNC). The photomicrographs are typical common carotid cross- sections stained for the markers ...
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Endothelial dysfunction of resistance vessels in female apolipoprotein E-deficient mice
... encoding apolipoprotein E (ApoE) and spontaneously develops hypercholesterolemia and ath- erosclerotic lesions similar to those found in human beings [2,3] has greatly contributed to the understanding of ...
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The Concurrence of Hypercholesterolemia and Aging Promotes DNA Damage in Apolipoprotein E Deficient Mice
... exhibited 6-fold higher levels of plasma cholesterol. The relative tail intensity, the percentage of tail DNA, has been the preferred and most suitable measure for DNA damage in many studies because it can represent a ...
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