Apolipoprotein E knockout
Interleukin-10 Deficiency Increases Atherosclerosis, Thrombosis, and Low-density Lipoproteins in Apolipoprotein E Knockout Mice
... that the crosstalk between IL-10 and IL-12 may play a crucial role in the pathogenesis of atherosclerosis (3,4,10,11,13,14). IFN- may destabilize plaques by inhibiting smooth muscle proliferation, differentiation, and ...
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Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase
... Apolipoprotein E knockout (apoE0) mice accumulate atherogenic remnant lipoproteins in plasma. We now provide evidence that these particles are enriched in sphingomyelin (SM), and explore the ...
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Sildenafil restores endothelial function in the apolipoprotein E knockout mouse
... Background: Atherosclerosis is an inflammatory process of the arterial walls and is initiated by endothelial dysfunction accompanied by an imbalance in the production of reactive oxygen species (ROS) and nitric oxide ...
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Modest vasomotor dysfunction induced by low doses of C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis
... In keeping with the notion that exposure to particulate matter in air pollution is associated with increased risk of cardiovascular diseases, engineered nanomaterials are expected to generate similar effects [3]. The ...
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Original Article The HMG-CoA reductase inhibitor rosuvastatin promotes complement factor H expression in apolipoprotein E-knockout mice
... With the exploration of new therapeutic strate- gies to treat atherosclerotic CVD, it is increas- ingly important to demonstrate the role of anti- atherosclerotic mechanisms in addition to the cholesterol-lowering effect ...
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-induced human umbilical vein endothelial cell (HUVEC) injury and apolipoprotein E knockout (ApoE-/-) atherosclerotic mice
... Original Article Inhibitory effects of oleoylethanolamide OEA on H2O2-induced human umbilical vein endothelial cell HUVEC injury and apolipoprotein E knockout ApoE-/- atherosclerotic mic[r] ...
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Vitamin D Deficiency and Exogenous Vitamin D Excess Similarly Increase Diffuse Atherosclerotic Calcification in Apolipoprotein E Knockout Mice
... hypertrophy [22]. Accelerated atherogenesis has also been reported to accompany VDR knockout in atheroma-prone LDL cholesterol receptor deficient mice [23]. However, the VDR 2/2 phenotype includes growth ...
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Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice
... of smooth muscle cells (SMCs) are attributed to trigger- ing of the atherosclerotic plaque formation (Hansson and Libby 2006). Monocytes are also recruited to the atherosclerotic lesion and transformed into macrophages ...
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Activation of renin-angiotensin system is involved in dyslipidemia-mediated renal injuries in apolipoprotein E knockout mice and HK-2 cells
... Immunohistochemical analysis and immunofluorescence Localization of RAS components in mice kidney was performed in paraffin-embedded sections. The slides were previously deparaffinized and treated with 0.3% en- dogenous ...
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Atherosclerosis differentially affects calcium signalling in endothelial cells from aortic arch and thoracic aorta in Apolipoprotein E knockout mice.
... There are differing reports of the effect of age on the functional vascular response to muscarinic-mediated relaxation in mice, with some studies showing impaired relaxation, as a result of increasing amounts of ...
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Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 111In-tilmanocept
... In addition, 111 In-tilmanocept uptake was detected in atherosclerotic plaques of mice containing MR-expressing macrophages suggesting that tilmanocept represents a promising tracer for [r] ...
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Deletion of the Mir-106b~ 25 MicroRNA cluster attenuates atherosclerosis in Apolipoprotein E knockout mice
... 1 Expression and effect of miR-106b~ 25 cluster members in atherosclerosis progression (a) Relative expression of the miR-106b~ 25 cluster members determined by quantitative real-time PC[r] ...
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Protective activity ethanol extract of the fruits of Illicium verum against atherogenesis in apolipoprotein E knockout mice
... Proteins were isolated from aortic tissue according to standard techniques [4], separated by 10 % sodium do- decyl sulfate-polyacrylamide gel electrophoresis and then transferred onto nitrocellulose membranes (Amersham ...
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Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 months
... Apo e neg, apolipoprotein e-negative; Apo e Pos, apolipoprotein e-positive; nA, not applicable; DFM, difference between means; ACe, Addenbrooke Cognitive examination; BMI, body ...
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Association of the Apolipoprotein E polymorphism with migraine: a meta-analysis
... Apolipoprotein E (ApoE) is a 299 amino acid protein, encoded by a gene located on chromosome 19cen-q13.2 [6, 7]. ApoE gene has three common alleles (ɛ2, ɛ3, ɛ4) that encode three isoforms (APOE2, APOE3, ...
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Apolipoprotein E gene polymorphism and renal function are associated with apolipoprotein E concentration in patients with chronic kidney disease
... APO: apolipoprotein; BMI: body mass index; BP: blood pressure; CKD: chronic kidney disease; CKD-EPI: chronic kidney disease epidemiology collaboration; CM: chylomicrons; CVD: cardiovascular disease; eGFR: ...
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A novel electrophoretic variant of human apolipoprotein E Identification and characterization of apolipoprotein E1
... confirming that the variant is an example of a previously uncharacterized apo E phenotype, E3/1. Both cysteamine modification and amino acid analysis demonstrated that this variant contains two cysteine residues ...
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Influence of apolipoprotein E polymorphism on apolipoprotein B 100 metabolism in normolipemic subjects
... The mean on-therRemnant accumulation is a hallmark of type III hyperlipidemia, and we noted that the VLDL, apo B curves observed in apy concentrations of plasma cholesterol, triglyceride[r] ...
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Apolipoprotein AI transgene corrects apolipoprotein E deficiency induced atherosclerosis in mice
... human apolipoprotein AI (apo AI) transgene in this genetic ...apo E deficiency--induced atherosclerosis, we introduced the human apo AI transgene into the hypercholesterolemic apo E knockout ...
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Immunohistochemical localization of apolipoprotein E in human glial neoplasms
... In addition, the immunofluorescence study using cultured cells indicated that the primary culture of the astrocytoma contained 80% GFAP positive cells and the cell line contained 5% or l[r] ...
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