apolipoprotein E-/- mice
Diet induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption
... apolipoprotein E (apo E) can affect atherogenesis, we have compared the consequences of dietary stress on normal mice and on mice heterozygous or homozygous for a disrupted apo E ...
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Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice
... apolipoprotein E-deficient (Apoe –/– ) mice sensitized with ovalbumin (OVA) together with aluminum, followed by OVA nebulization three times a ...–/– mice followed by OVA weekly nebulization ...
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Hypercholesterolemia promotes early renal dysfunction in apolipoprotein E-deficient mice
... hypercholesterolemic apolipoprotein E-deficient mice (ApoE, n = 13) and age-matched C57BL/6 control mice (C57, n = 15) were studied at 2 (young) and 8 (adult) ...
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Deficiency of Glycine N-Methyltransferase Aggravates Atherosclerosis in Apolipoprotein E-Null Mice
... The mechanism underlying the dysregulation of cholesterol metabolism and inflammation in atherogenesis is not understood fully. Glycine N-methyltransferase (GNMT) has been implicated in hepatic lipid metabolism and the ...
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Serum Amyloid A Directly Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice
... SAA–treated mice. In addition, MCP-1 expression in aortas was upregulated with the increased plasma level of SAA. These data in vivo agree with previous results in vitro (20,21). SAA induced VCAM-1 expression in ...
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Thymoquinone reduces cardiac damage caused by hypercholesterolemia in apolipoprotein E-deficient mice
... −/− mice were purchased from Beijing Vital River Lab animal technology ...All mice were maintained under constant conditions (temperature, 23–25 °C; humidity, 40–60%; 12 h light/dark ...male mice ...
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The Concurrence of Hypercholesterolemia and Aging Promotes DNA Damage in Apolipoprotein E Deficient Mice
... C57 mice showed a higher % of cells in levels 0 (28%) and 1 (46%), and similar values were observed in young C57 and young apoE −/− ...−/− mice showed a ...
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Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E
... normal mice were cleared from plasma at a significantly slower rate than normal mouse VLDL, demonstrating the impaired catabolism of ...transgenic mice expressing high levels of the dysfunctional apo ...
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Chylomicronemia due to apolipoprotein CIII overexpression in apolipoprotein E null mice Apolipoprotein CIII induced hypertriglyceridemia is not mediated by effects on apolipoprotein E
... gels with a 3% stacking gel (Bio-Rad Laboratories, Inc., Hercules, CA). A constant amount of protein was loaded for each lipoprotein species on each gel. Gels were run with 5, 10, and 20 m g of VLDL loaded. The ratio of ...
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Treatment of severe hypercholesterolemia in apolipoprotein E deficient mice by bone marrow transplantation
... E0-treated-HF mice after 14-16 wk was greatly reduced. Wild-type apo E mRNA was detected in the liver, spleen, and brain of the E0- treated mice indicating that apo E gene transfer was ...
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Mononuclear cell therapy reverts cuff-induced thrombosis in apolipoprotein E-deficient mice
... However, our study has some limitations that need to be addressed. First, it would be interesting to demon- strate the direct relationship between cuff placement and hemodynamic alterations. The measurement of ...
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Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice
... (TR) mice 'humanized' at apoE were devel- oped by ...APOE mice contain chimeric genes consisting of mouse 5' regulatory sequences continuous with mouse exon 1 (noncoding) followed by human exons (and ...
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Effect of hyperlipidemia on the expression of circadian genes in apolipoprotein E knock-out atherosclerotic mice
... [23,24]. However, the different expression pattern is that the peak mRNA of circadian genes (Bmal1, Cry1 and Per2) with four hour delayed occurred at the starting of subjective dark period, while transcription factor ...
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Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E
... in mice that overexpressed apo E ...particle. E 1 VLDL was enriched with rat apo E compared to E 2 VLDL ...than E 2 VLDL when injected into wild-type mice with the func- ...
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PEP 1 MsrA ameliorates inflammation and reduces atherosclerosis in apolipoprotein E deficient mice
... Blood samples were collected from mice after overnight fasting by retro-orbital venous plexus puncture at 4 week intervals. Plasma was immediately separated by cen- trifugation at 10,000×g for 10 min at 4 °C. ...
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Secretion recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice
... To investigate the role of apoE in hepatic uptake of chylomicron remnants, we studied chylomicron metabolism in transgenic mice overexpressing apoE in the liver. Plasma clearance of injected 125I-labeled human ...
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Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors
... apoE-deficient mice with preinfusion plasma total cholesterol of 644 +/- 149 mg/dl an cholesterol rich ...of mice infused with ...control mice infused with ...
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The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E / mice
... four mice in each group after fractionation by fast protein liquid chroma- tography (FPLC) gel filtration (Pharmacia LKB Biotechnology, Upp- sala, Sweden) on two Superose 6 columns connected in series ...
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CD6 expression has no effect on atherosclerosis in apolipoprotein E deficient mice
... Results: We compared cholesterol levels, IgM, B1a cells, and aortic root lesion areas in ApoE‑deficient vs. CD6/ApoE double deficient mice. Feeding the high‑fat western type diet increased all parameters, except ...
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Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E deficient mice
... untreated mice showed a dense accumulation of lipid-filled foam cells near the surface, and the lipid present within the plaque was largely in- tracellular ...probucol-treated mice showed diffuse and ...
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