Apoptosis and autophagy
Original Article Studying the mRNA and protein expression pattern of apoptosis and autophagy-related genes in renal cell carcinoma
... physiology, autophagy is main- tained at the basal level and can respond quickly to various stimuli and extracellular sig- nals ...of autophagy-related genes significantly changed, which also indicate the ...
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Bufalin Induces the Interplay between Apoptosis and Autophagy in Glioma Cells through Endoplasmic Reticulum Stress
... induced apoptosis through mitochondrial apoptotic ...stress-mediated apoptosis, which was supported by the up- regulation of ER stress markers, CHOP and GRP78, and augmented phosphorylation of PERK and ...
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<p>LncRNA SNHG11 Promotes Proliferation, Migration, Apoptosis, and Autophagy by Regulating hsa-miR-184/AGO2 in HCC</p>
... of apoptosis and autophagy related protein: AGO2, Beclin-1, LC3 II/LC3 I, cleaved Caspase3, and AGO2, Beclin-1, and LC3 II/LC3 I expression was decreased and cleaved Caspase3 expression was increased in the ...
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Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells
... between apoptosis and autophagy is very ...that autophagy has cyto- protective effect and negatively regulates apoptosis under physiological ...contrary, apoptosis inhibits the process ...
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Effects of Hypoxia on Oxidative Stress, Autophagy and Apoptosis in Cardiomyocytes
... stress, apoptosis and autophagy, as well as the relation- ships among these ...that autophagy levels are in accord with ...stress, apoptosis and autophagy in cardiomyocytes. ...
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Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells
... induced apoptosis in human ESCC Ec109 and KYSE70 ...induced autophagy in both Ec109 and KYSE70 cells via suppression of the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin ...
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<p>Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage</p>
... GSH and SOD are intracellular antioxidants, while MDA serves as an indicator of lipid peroxidation, which all play a vital role in the action of apoptosis and autophagy. 29,30 In this study, TET treatment ...
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Plumbagin induces G<span style="font-size: 8.3333330154419px">2</span>/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
... an autophagy inducer), and fetal bovine serum (FBS) were bought from Thermo Fisher Scientific ...(PE) apoptosis detec- tion kit was purchased from BD Biosciences ...® Autophagy detection kit was ...
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Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells
... and apoptosis in K562 and KU812 cells. Apart from induction of apoptosis, we reported for the first time that asparaginase induced autophagic response in K562 and KU812 cells as evidenced by the formation ...
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MiR-216a in Diabetic Nephropathy: Relation with Autophagy and Apoptosis
... that apoptosis contributes to the development of ...causes apoptosis [32] through activation of a network of intracellular signaling pathways including the phosphatidylinositol 3 kinase (PI3k)/(AKT) ...
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Chloroquine, an autophagy inhibitor, potentiates the radiosensitivity of glioma initiating cells by inhibiting autophagy and activating apoptosis
... an autophagy blocker chloroquine in GICs, and aimed to further understand the molecular mecha- nisms of its ...with autophagy and the late autophagy inhibitor chloroquine in combination with ...
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Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment
... doxorubicin-induced autophagy in human osteosarcoma U2OS cells through upregulating beclin1, which revealed a synergistic cytotoxicity, leading to U2OS cell death ...promoted autophagy by inducing Bcl-2 ...
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The mechanisms of graphene-based materials-induced programmed cell death: a review of apoptosis, autophagy, and programmed necrosis
... between apoptosis, autophagy, and programmed necrosis may benefit to figure out further the mechanism of GBMs-induced ...of autophagy and apoptosis was limited by the experimental conditions ...
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Autophagy protects against palmitate-induced apoptosis in hepatocytes
... [16,17]. Autophagy, a cellular self-catabolic process, maintains cellular homeosta- sis by trafficking accumulation of damaged proteins and organelles to lysosomes for proteolytic degradation ...that ...
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Original Article Overexpression of PTEN enhanced gemcitabine-induced apoptosis by promoting autophagy in osteosarcoma cell line MG-63
... induce autophagy in MG-63 cell and PTEN-mediated autophagy was required for enhancing apoptosis induced by Gemcitabine, which suggested that PTEN could en- hance apoptosis induction via ...
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<p>Irinotecan Induces Autophagy-Dependent Apoptosis and Positively Regulates ROS-Related JNK- and P38-MAPK Pathways in Gastric Cancer Cells</p>
... induced apoptosis in gastric cancer ...caused autophagy in these cells, whereas autophagy inhibitors — 3-methyladenine (3-MA), chloroquine (CQ), and Beclin-1 small interfering RNA (siRNA) — ...
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MicroRNAs in apoptosis, autophagy and necroptosis
... the autophagy-inducing complex, Beclin-1 and Class III ...from autophagy to ...in apoptosis induction by targeting proteasomal degradation ...of autophagy via different pathways depending on ...
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Cytotoxicity Studies of TiO2/ZnO Nanocomposites on Cervical Cancer Cells
... Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy. Multifunctional nanopartic[r] ...
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The relationship between apoptosis and aging
... aging, apoptosis acting in a cell type- specific manner. The rate of apoptosis is elevated in- most types of aging cell populations and ...cells, apoptosis serves to eliminate presumably dysfunc- ...
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Enhanced Autophagy in the Kidney of AQP11 Null Mice Developing Polycystic Kidneys
... cysts, autophagy may play a role in their survival. We examined the autophagy activity before and after the development of cysts in AQP11(−/−) ...other autophagy-related genes in AQP11(−/−) mice by ...
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